DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Root and Whamm

DIOPT Version :9

Sequence 1:	NP_001287497.1	Gene:	Root / 42860	FlyBaseID:	FBgn0039152	Length:	2048	Species:	Drosophila melanogaster
Sequence 2:	NP_001004185.3	Gene:	Whamm / 434204	MGIID:	2142282	Length:	793	Species:	Mus musculus

Alignment Length:	880	Identity:	172/880 - (19%)
Similarity:	298/880 - (33%)	Gaps:	287/880 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   783 SAGEKLKCLQLEKEKILQDLAC---VTRD-----RGDIHNQLTAMCR-----KKEALNEELMRTR 834
            ||.::| |.|||....|....|   ..||     .||     :|.|.     ::..|...|.:|.
Mouse   133 SALQEL-CRQLEHYLGLAAEGCGGATVRDVLFPAPGD-----SADCEGLSEFRERTLRARLGQTA 191

  Fly   835 QRLEQTTETNSRLNRNLEEMVKDVEEKQVVIDLHEKDTHRLNELLAALRSEKESLESVLFDTNTS 899
            .||.|..:.:.:.|..:..|....||.::..:|....|.....||...|..:|...|.......|
Mouse   192 TRLHQVLQDHGKANTMVALMKVYQEEDELYQELVTMATTFFQYLLQPFRDMREVATSCKLGILKS 256

  Fly   900 LEATE--ERRSQLERDLQEALVREESLKNHVARLQKELEQCQRKAQETKTQLLNAARAAESDFNQ 962
            |:..|  .||                    ||.||||..:..|:|:|.
Mouse   257 LDEDELGPRR--------------------VAALQKEASEWTRQAEEA----------------- 284

  Fly   963 KIANLQACAEEAAKRHGEEILQLRNALEKRMQQALQALQTAKDDEIEKLQERLATLQAHLESL-- 1025
             :.::|    :....:.:|.:.....::|:|:|          |:....|...||....||:|
Mouse   285 -VGSIQ----DITVNYFKETVTALTGMQKQMEQ----------DQKRFGQAAWATAMPRLENLKL 334

  Fly  1026 -VQQHEEALIRAESEKQQALLIAHRDKQAVAERLEAVSRDLKTEQESLDRSRREANARDEKQRAA 1089
             :.:....|:||:.     |.:.||  ||          :::.:.|.|.|..::.:..||
Mouse   335 MLARETLQLMRAKE-----LCLKHR--QA----------EIQRKVEDLPRQGKQLDVVDE----- 377

  Fly  1090 IAQLKDEMVQMRTKEEEHKIKLEECIRKQELQLSSLREERESLCRVSEELKMEIRLKEDRMESTN 1154
             .:::...:|:    |.:.:|||....::.:.::.|    :|:.|:..|.:.|: :..|..||.
Mouse   378 -LEIQCYEIQL----ELYDVKLEMLRNEETILVTRL----DSVKRLITEKQAEV-IYYDPCESP- 431

  Fly  1155 NELQDALRKSKEGEGFIDSLRKELTDCRRQLADSNIERDKYSGSNKELRDHVKRVESAKREQARA 1219
            .|||              ||..:|              :.:.|.|:||               ||
Mouse   432 EELQ--------------SLAPDL--------------ELHLGDNREL---------------RA 453

  Fly  1220 IEEALQKISNLEDTKNSLENERTRLST---ILKETENHFTKTTQDLNATKAQLQKAQVEFAQKDE 1281
            :.:..|:          ||.:|.|:.:   :|:..::|..:..|      .:||:|:.......:
Mouse   454 LSQQCQR----------LEAQRGRICSRRALLRNRKDHCRENHQ------LRLQQAKQSLRHLHQ 502

  Fly  1282 GGKELQCKLVAEVELKERAQQELCQIKKQLSDLEANLCATRQELGRARCQNNQEEHRFHAR---E 1343
            .         ..:::|....:|..|.||:..|.|......|....:.:|    ..||...:   .
Mouse   503 H---------HSIQMKRDKVKEEEQKKKEWIDHERQKTLERLRAYKEKC----PAHRSALKTTCS 554

  Fly  1344 QELAQRLEEGRGREKRLEDQKHNLEVCLADATQQIQELKARLGGA----EGRIRALDEQLSC--- 1401
            :.:...|..||. :|||....|:         :......::.|.|    |..:|..:.|..|
Mouse   555 ESMVSNLPGGRS-QKRLSTAHHH---------KTAHPASSKTGSAVPLPEASVRPPEHQDPCGSV 609

  Fly  1402 -VELHKRDTEQKLSSVVHTLRRIAGIQVDGSVNLSHRLLSPSRRFSPSRSCGDYDNRSTSQCPDG 1465
             |:.....::|.||.              .|.:||.....|:....|...            |..
Mouse   610 PVQAFVPVSDQTLSG--------------SSEDLSLPPQPPAPPLPPPPP------------PPP 648

  Fly  1466 PIDVDPDLVRKGVRNLMHQVAQLEREKDDYKSQLGAAKKQLQDAADQQLRCDAKLGK-------- 1522
            |..:.|.|  ...:...||             .||......:| ....|.||...|:
Mouse   649 PPPLPPAL--SSFQGTTHQ-------------NLGLRTLATED-RPLPLACDPSAGRPCDYQGPG 697

  Fly  1523 -LQAMLRNLQEEKSNLETDRKM---------------------------KISAIQALEEKLKHRN 1559
             :..:|.:|::.|::|   ||:                           |:...|.::...|..:
Mouse   698 SMDEVLASLRQGKASL---RKVETPTLPHPGTSVNEQVLAAIRQGVQLKKVHTGQGVDPGKKSTS 759

  Fly  1560 DECQMLRERLAQTEMQLAATSEENGQNEERLEKSR 1594
            |..:.:||.|.:.: :::|.|||:.......|..|
Mouse   760 DLERSIREALERIK-KVSADSEEDNDEPSPTEWDR 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Root	NP_001287497.1	Rootletin	110..332	CDD:291694
		Smc	555..1384	CDD:224117	125/624 (20%)
		SMC_prok_B	991..>1779	CDD:274008	124/657 (19%)
Whamm	NP_001004185.3	Mediates association with membranes. /evidence=ECO:0000250\|UniProtKB:Q8TF30	1..253		32/125 (26%)
		WHAMM-JMY_N	5..51	CDD:292542
		JMY	67..435	CDD:292496	85/392 (22%)
		Mediates interaction with microtubules. /evidence=ECO:0000250\|UniProtKB:Q8TF30	254..623		101/535 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..661		26/142 (18%)
		Mediates actin nucleation. /evidence=ECO:0000250\|UniProtKB:Q8TF30	624..793		36/214 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..699		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	772..793		5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000