DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Root and jmy

DIOPT Version :9

Sequence 1:	NP_001287497.1	Gene:	Root / 42860	FlyBaseID:	FBgn0039152	Length:	2048	Species:	Drosophila melanogaster
Sequence 2:	NP_998437.1	Gene:	jmy / 406556	ZFINID:	ZDB-GENE-040426-2433	Length:	846	Species:	Danio rerio

Alignment Length:	751	Identity:	162/751 - (21%)
Similarity:	264/751 - (35%)	Gaps:	241/751 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   970 CAEEAAKRHGEEILQLRNALEKRMQQALQA-LQTAKDDEIEKLQERLA-----TLQAHLESLVQQ 1028
            |.....::...|...|..|.|..:..|... .:||:.......:||..     :..|.|| |:..
Zfish    46 CHNRTVQKRSAERDSLLEAAEGELAAAADTDRRTARPAHRSPGRERSGGQSSPSAAAELE-LLDA 109

  Fly  1029 HEEALIRAESEKQQALLIAHRDKQAVAERLEAVSRDLKTEQESLDRSRR----------EANARD 1083
            .|:|.:.|..:...|.|.:.:|.:|...:|.||:.||:....:|...:.          |.:|||
Zfish   110 AEDAELSARQDSSWAGLFSFQDLRAAHLQLCAVNADLEPCLPALPEEQTGVWSVLFGVPEMSARD 174

  Fly  1084 EKQRAAIAQLKDEMVQMRTKEEEHKIKLEEC---IRKQEL--QLSSLREERESLCRVSEELKMEI 1143
            ..  |...||:..:..          .|:.|   |..|.|  ......|..|||        .|:
Zfish   175 TD--ALCFQLQVYLGH----------ALDTCGWRILSQVLFPDSEDAEEYYESL--------SEL 219

  Fly  1144 RLK--EDRMESTNNELQDALRKSKEGEGFIDSLR--KELTDCRRQLADSNIERDKYSGSNKELRD 1204
            |.|  ||.::.....||..|.:.:..|..::.|:  .|..:...:|.::..|  .|....:..||
Zfish   220 RQKGYEDALQRAKRRLQQLLEQQRAVERMVELLQLYSEQDEAYGELVEATTE--LYHYLLQPFRD 282

  Fly  1205 HVKRVESAKREQARAIEEALQKISNLEDTKNSLENER---TRLSTILKETENHFTK------TTQ 1260
             ::.:...:|:|                .|.|||.||   .|:.::.:|.|:...|      :.|
Zfish   283 -MRELAMLRRQQ----------------IKISLETERLGPRRVESLRREDEDWQRKAHTAVLSIQ 330

  Fly  1261 DLNA----TKAQLQKAQVEFAQKDEG--GKELQCKLVAEVELKERAQQELCQIKKQLSDLEANLC 1319
            ||..    |.|:.||...|..:.|:.  ||   ....|.||..||.|
Zfish   331 DLTVKYFETTARAQKVMYERMRADQRKFGK---AAWGAAVERMERLQ------------------ 374

  Fly  1320 ATRQELGRARCQNNQEEHRFHAREQELAQRLEEGRGREKRLEDQKHNLEVCLADATQQIQELKAR 1384
                                :|..:|..|.:   |.:|..||.:||.|.          :|::..
Zfish   375 --------------------YAVSKETLQLM---RAKEICLEQRKHGLR----------EEMQGL 406

  Fly  1385 LGGAEGRIRALDE--------QLSCVELH---KRDTEQKLSSVVHTLRRIAGIQVDGSVNLSHRL 1438
            .||.:...| ||:        ||...|:.   .::.|..|::.:.:|||          .:|.|
Zfish   407 QGGEDAMAR-LDQLEALYYELQLQLYEIQFEILKNEELLLTAQLQSLRR----------QMSER- 459

  Fly  1439 LSPSRRFSPSRSCGDYDNRSTSQCPDGPIDVDPDLVRKGVRNLMHQVAQLEREKDDYKSQLGAAK 1503
                     ......||   |.:.||                                     |.
Zfish   460 ---------QEEVVYYD---TFESPD-------------------------------------AM 475

  Fly  1504 KQLQDAADQQLRCDAKLGKLQAMLRNLQEEKSNLETDRKMKISAIQALEEKLKHRNDEC-----Q 1563
            |..:|.|..|...| .:.|||...|.|:.        |:.:|:|.:|.   ||::.:.|     |
Zfish   476 KATEDPAQPQTPRD-DINKLQQRTRQLEA--------RRGRITAKKAY---LKNKKEICIINHTQ 528

  Fly  1564 MLRERLAQTE--MQLAATSEENGQNEERLEKSRQQCSKLDNEKRQLQEELAKVEGRASKLELQRV 1626
            .|::|.|...  .|.....:|..:.|:||       |::..|:::..:.|...:.|..    .:|
Zfish   529 KLQQRQAGAHGVSQQPLLQDEEDEEEQRL-------SRVSQERQRTLDRLRSFKQRYP----GQV 582

  Fly  1627 AMEGDLTRLQMALQEKDCSIRQMAERLENQNRALTQ 1662
            .::.  |||::|...|. ::|  ||:::.|.:..||
Zfish   583 TLKS--TRLRLAFSRKK-ALR--AEQMQTQTQPQTQ 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Root	NP_001287497.1	Rootletin	110..332	CDD:291694
		Smc	555..1384	CDD:224117	99/453 (22%)
		SMC_prok_B	991..>1779	CDD:274008	157/730 (22%)
jmy	NP_998437.1	WHAMM-JMY_N	5..54	CDD:292542	1/7 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..100		5/31 (16%)
		JMY	123..476	CDD:292496	103/506 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	472..494		8/59 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	533..572		9/45 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..717		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..846
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000