Protein Alignment Root and Crocc2

DIOPT Version :9

• Sequence 1: NP_001287497.1
• Gene: Root / 42860
• FlyBaseID: FBgn0039152
• Length: 2048
• Species: Drosophila melanogaster
• Sequence 2: XP_006530046.1
• Gene: Crocc2 / 381284
• MGIID: 3045962
• Length: 1698
• Species: Mus musculus
• Alignment Length: 2024
• Identity: 451/2024 - (22%)
• Similarity: 821/2024 - (40%)
• Gaps: 543/2024 - (26%)

  Fly    98 LRQRLADESHSYRRRLDTYKQAQHNQANLVSRLQSKIQQYRQRCSDLEERMHETIKPTAGVGPKL 162
            ||:..|..||: |...:..::......:|:::..::.::...||..:.:|:...
Mouse    78 LREPPATTSHA-REESELLQEELTRLEDLLAQADAEREELASRCHMVSQRLQAR----------- 130

  Fly   163 TTGPTNQVLCSTSLTLGQSSLPCSSSLDSPPPSCSRDYVDDVLVTGGGAGAAELCRKLEEEHQRC 227
                    |.:|...|.:|.|..|..|:                        |...:||...||.
Mouse   131 --------LDTTEARLRKSELEHSMDLE------------------------EALSRLEASQQRS 163

  Fly   228 EQIVAQNSALRQQLEESNRTNEALTNDLQKLTNDWASLRDELLIKEDEFKEEEQAFKDYYNSEHN 292
            ..:...|:.||||||...:.|:.|..:|.:.|:....|:.:|.::|.:.....|. :|
Mouse   164 MGLSQVNTLLRQQLEHMQKANDTLARELTRATHSLVHLQRKLELQESQRLSLRQP-RD------- 220

  Fly   293 RLLKMWREVVAVKRSFKEMQ-------TAMKAEVAKMGQEIN--CVGKD----INGSNATVAFAV 344
             :|.:||:..|::....|::       |.::|::.:..|.::  |:..|    :..|:.|
Mouse   221 -ILPLWRQAKALQTHLAELRASTERGLTDVQADMTRTAQRLHMACLNLDSHLRLTASSMT----- 279

  Fly   345 QQAKRAADDELKQSQRSNDELQNQLATLKVQYESARHE---IMER--------DQRLLELMNQLK 398
                ...:..|::..|...:||.|.|..||..::...|   ::|:        ::.:|.|.:.::
Mouse   280 ----SDLEQRLREQAREMLQLQGQWAAEKVALQARLSEQTLLVEKLSVQKEQGERAILTLKSDIQ 340

  Fly   399 KLEDRCAQAESQAALASRYSDEIERLNN---SMREIAQAVVQDAENA------DREADAEVTG-- 452
            :|:.|  ::..|.|: ....||:|.|::   |::|:||:.....|.|      .|||.|.:..
Mouse   341 RLKSR--RSGGQLAV-DELRDEVESLHHVLASIKEVAQSDAMCPELAWSSSIEVREAQARLRSPP 402

  Fly   453 -GVMQHMHLTRDAASVVGGAGGAGSTAGGGGKSPRRNSTRASQAFAEGTISAVQAALHKYQLALH 516
             .|..|..:                       ||.|.|:..|   ....:.|||||:.:.|....
Mouse   403 RSVSPHQRM-----------------------SPARTSSPTS---LHPALQAVQAAIERRQQREQ 441

  Fly   517 DMQVKFQNTSETLRTTKAQLETSEGTKQLLTTKMQQLTEKLDSSNSKLSELLQERESLQRGLDDI 581
            :::::.:::.|.....:.||   .|.:|.|.|..:.|.::.......|.:|..:|:..|.....:
Mouse   442 ELRLRLESSQEEAAGLREQL---SGYRQELRTSQRLLQDRAQEHEDLLGQLEAQRQEAQLSQASV 503

  Fly   582 RVQKQQSE---------MGRADINSAFENLSSDYEKMQLNCGKLQKRIDSMEEDKKAVELEIQRI 637
            .:.:::.|         ..:|||..|      :.:|:::...:|::.:....|.|..:..:.:|.
Mouse   504 HLLEREKEALETTMEELRAKADIREA------ETQKLEVTNAELRRSLLLRAEQKAELAQQSERS 562

  Fly   638 LKDKNITELNLRSEEDRSSRLREETISLREELNRVSLNRDLLEQQRIESDNLINLLEKQKSDLEY 702
            |::...::..:...|::.|.||:|..:.||.|:.:.|.||:||.::......:...|...:|||.
Mouse   563 LRELEASQGRVEQLEEKVSGLRKELATSREALSSMQLQRDILETEKESLHGALAQAESGNADLEL 627

  Fly   703 DLDKLLLEKCDLQEKHEKLSNNSCSTSDELKSVQNCLQEAQEERKKLRIQSVDQCNEIGELKKEL 767
            .:.:|..|..:.|:...|::......|.:..::.:...:.::||.:||.|......|...::::|
Mouse   628 LVTRLKAEGMEQQDSLAKMAALLEGLSQDKGTLNHLALQLEQERDQLREQQKMLQQEQAGMREQL 692

  Fly   768 AILDKARLELETDNLSAGEKLKCLQLEKEKILQDLACVTRDRGDIHNQLTAMCRKKEALNEELMR 832
            .              ..|::|..::.|:..:.:....:.:.:..:..|:.       .|.:|..:
Mouse   693 T--------------QTGQQLGLIRAERRSLKETCGHLEQKQDHLEKQVV-------LLGQENAQ 736

  Fly   833 TRQRLEQTTETNSRLNRNLEEMVKDVEEKQVVID--LHEKDT---------------HRLNELL- 879
            .|:::.|.|.....|.:.|.:.::|.|.:..::.  ||||:|               .|.:||:
Mouse   737 LREQVGQVTNKKQALEKQLAQSLQDQEAQMDILQEALHEKNTLSEERAQLLAKQEALERHSELVT 801

  Fly   880 ---AALRSEKESLESVLFDT---NTSLEATEE------------RRS---QLERDLQEALVREES 923
               |.||:|:.|||:.||:.   .|.|:..:|            ||:   ::||...:..|||..
Mouse   802 KEAADLRAERNSLENSLFEAQRLTTQLQTQQEQLEGKAEAAQLARRALQVEIERLKSDWEVRETK 866

  Fly   924 LKNHVARLQKELEQCQRKAQETKTQLLNAARAAESDFNQKIANLQACAEEAAKRHGE-EILQLRN 987
            |:.|:.:||::..|     ||.:.||     |.|   .|::|:    .|:.|:.|.| :.|.|..
Mouse   867 LQLHLGQLQQQAAQ-----QEQEAQL-----ALE---RQELAH----TEDLARLHREKDTLSLSL 914

  Fly   988 ALEKR-----MQQALQAL-QTAKDDEIEKLQERLATLQAHLESLVQQHEEALIRAESEKQQALLI 1046
            |.||.     |:|..:.| ::|.|.|         .||..:::|.|:.:|:|::.|.|.||||.:
Mouse   915 AEEKEAAARWMEQQKELLTRSAADRE---------ALQGEIQNLKQERDESLLQLEHEMQQALSL 970

  Fly  1047 AHRDKQAVAERLEAVSRDLKTEQESLDRSRREANARDEKQRAAIAQLKDEMVQMRTKEEEHKIKL 1111
            ...:|..:::.|....|:       |:|:|:||..:..:..|.:..:..|   :||.:    ::.
Mouse   971 KDAEKSLLSKELSGAHRE-------LERARQEAQNQQVQAEATVTTMTKE---LRTLQ----VQF 1021

  Fly  1112 EECIRKQELQLSSLRE-------ERESLCRVSEELKMEIRLKEDRMESTNNELQDALRKSKEGEG 1169
            ||.|...:.:..:|||       ||.|:.|.:|||:.::.:..:|:.....||| |..:|:||
Mouse  1022 EEAISTHQREADTLREKLREIAAERSSVRREAEELQAQLNVAHERLAELRQELQ-ASEESREG-- 1083

  Fly  1170 FIDSLRKELTDCRRQLADSNIERDKYSGSNKELRDHVKRVESAKREQARAIEEALQKISNLEDTK 1234
                |::|....||.|.|...|:|....||.|||..:.|.|..|....|:.||..||:..|::.:
Mouse  1084 ----LQREALGARRALEDEVQEKDVLQHSNTELRASIHRAEQEKASLKRSKEEQEQKLLLLQEAQ 1144

  Fly  1235 NSLENERTRLSTILKETENHFTKTTQDLNATKAQLQKAQVEFAQKDEGGKELQCKLVAEVELKER 1299
            .:.:.|...|.|.|:|.|.....|.:.|.....|::..:.|..:|.:...:||.::..:.:.:::
Mouse  1145 VAAQKEAYELRTRLQELERAQRDTRRKLQERHRQVRTLEAENQRKRQEVSDLQAQVSRDAQHRQK 1209

  Fly  1300 AQQELCQIKKQLSDLEANLCATRQELGRARCQNNQEEHRFHAREQELAQRLEEGRGREKRLE--- 1361
            ..||..::::|:::.:|.....::|:...|              |:||:....|..|.|:||
Mouse  1210 NLQESLELQRQVAEAQAAHDGVQKEVLGLR--------------QKLAEVEASGETRAKQLEGHL 1260

  Fly  1362 ------DQKHNLEVC-----LADATQQIQELKARLGGAEGRIRALDEQLSCVELHKRDTEQKLSS 1415
                  :|....|:|     |.:|:.|...|:..|..|..|:..|:::|:..|..:.:.|.:|..
Mouse  1261 CESQRAEQTLQAELCRITRKLQEASNQADSLQRSLDNACSRVHVLEQELAKAEGARCNAEAQLGR 1325

  Fly  1416 VVHTLRRIAGIQVDGSVNLSHRLLSPSRRFSPS-----------RSCGDYDNRSTSQCPDGPIDV 1469
            :..||  .:|:  ..|.||   |.||.|..||:           |:.....:.|.::.| .|:.|
Mouse  1326 LWSTL--CSGL--GQSRNL---LASPKRPHSPTTGSSQTRPGRQRTSPPTRSYSPARWP-SPVPV 1382

  Fly  1470 DPD-------LVRKGVRNLMHQVAQLEREKDDYKSQLGAAKKQLQDAADQQLRCDAKLGKLQAML 1527
            ||.       .||..:|:|:..:.:.::|:|:...|:.....||.:|.
Mouse  1383 DPKSEVIDVAFVRDALRDLVQGLLEAQQERDNSGIQVANLSSQLSEAE----------------- 1430

  Fly  1528 RNLQEEKSNLETDRKMKISAIQALEEKLKHRNDECQMLRERLAQTEMQLAATSEENGQNEERLEK 1592
                                                  ||||
Mouse  1431 --------------------------------------RERL----------------------- 1434

  Fly  1593 SRQQCSKLDNEKRQLQEELAKVEGRASKLELQRVAMEGDLTRLQMALQEKDCSIRQMAERLENQN 1657
                  :|.:...|||.:||..|      |.||        |.:.|||.     .|.|..|  |.
Mouse  1435 ------RLQSRVEQLQRDLADAE------EGQR--------RAESALQS-----AQAARAL--QK 1472

  Fly  1658 RALTQLEDRCTALKSTVDQLKERLQKSAVSETQLRGEIKTLQKELSEQGHCSQANEDKLKLVQKS 1722
            .||.:||....|......|.:.|||:          ::.||::.|.|....||:..||.:|:::.
Mouse  1473 EALQRLETEHLASARAAGQERRRLQE----------QVDTLRQALEESSRPSQSLADKGRLLEQP 1527

  Fly  1723 LQTAENEKRILT-ERLDSAQTNLNELRRSQQAQLDGNQRLQEQVTDLEVQRSALESQLRIAKWNQ 1786
            ||      ::|. .|.|.|:      ||:          |:||.|.|..:|:.|:.:|
Mouse  1528 LQ------QVLPHSRRDRAE------RRA----------LREQTTSLRTERARLQGEL------- 1563

  Fly  1787 ESGGDKDLTNGNGGGNGEEELSRQLKSSQREKSELRSKL-QTLQDKVKQLECDRKSKFSGGNAYD 1850
                                            :.||::| ||.|:.:|:.|             |
Mouse  1564 --------------------------------AALRTRLIQTEQETLKKEE-------------D 1583

  Fly  1851 RAEKSNSFYGGAAESGEFDSNRYDVGGGNAGGGSFNCGLDHSVIEQETRDLRLKVRRLETLLAEK 1915
            ||..      ||.:.....|                  |.|  :.||......:.::|:..:||.
Mouse  1584 RAML------GAKKELLLQS------------------LSH--LHQEVDGALRQSQQLQAQMAEL 1622

  Fly  1916 ESELARCKARMNDSAKCHD---GLDGDRYRSAQMHAEKLLDAREQSHRQQVLRLENQISMLREQL 1977
            |....:   |:.:.|..|.   ..:..|...||:.|.:.|::.||.|:|:|..||.|::.|:::|
Mouse  1623 EQAHTQ---RLQELAAQHQRDLAAEAQRLHEAQLQATQALESCEQIHQQRVKVLERQVASLKKRL 1684

  Fly  1978 AQEAKRRQQ 1986
            .:|..:|||
Mouse  1685 DKEVWQRQQ 1693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Root	NP_001287497.1	Rootletin	110..332	CDD:291694	42/230 (18%)
		Smc	555..1384	CDD:224117	213/904 (24%)
		SMC_prok_B	991..>1779	CDD:274008	200/833 (24%)
Crocc2	XP_006530046.1	Rootletin	119..259	CDD:373494	38/191 (20%)
		SMC_prok_B	435..1248	CDD:274008	210/903 (23%)
		SMC_prok_B	949..>1675	CDD:274008	228/986 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836422
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001653
OrthoInspector	1	1.000	-	-		otm42977
orthoMCL	1	0.900	-	-		OOG6_106109
Panther	1	1.100	-	-	O	PTHR23159
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840