DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Root and Cep250

DIOPT Version :10

Sequence 1:NP_651216.2 Gene:Root / 42860 FlyBaseID:FBgn0039152 Length:2048 Species:Drosophila melanogaster
Sequence 2:NP_001414123.1 Gene:Cep250 / 311573 RGDID:1562262 Length:2428 Species:Rattus norvegicus


Alignment Length:2558 Identity:561/2558 - (21%)
Similarity:993/2558 - (38%) Gaps:734/2558 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 MSPGPPGAGGGGGGGVSGGGSGDPSALLRQNQE----LRQRLADESHSYRRRLDTYKQAQHNQAN 125
            |..|.||.            :..|.:|....:|    |:|::|....:..|:|...::||..||.
  Rat     1 METGSPGL------------NMKPQSLQLVLEEQVLALQQQMAQNQAASWRKLKNSQEAQKRQAT 53

  Fly   126 LVSRLQSKIQQYRQRCSDLEERMHETIKPTAGVGPKLTTGPTNQVLCSTSLTLGQSSLPCSSSLD 190
            ||.:||:|:.|||..|.|||:|    ::.|.|:.|:..                       .|::
  Rat    54 LVRKLQAKVLQYRSWCQDLEKR----LEATGGLIPQRW-----------------------ESVE 91

  Fly   191 SPPPSCSRDYVDDVLVTGGGAGAAELCRKLEEEHQRCEQIVAQNSALRQQLEESNRTNEALTNDL 255
            .|                   ...:|..:||||.||||.:|..|:.||..:|:::..|:||..|:
  Rat    92 EP-------------------NLEQLLIRLEEEQQRCESLVEVNTELRLHMEKADVVNKALQEDV 137

  Fly   256 QKLTNDWASLRDELLIKEDEFKEEEQAFKDYYNSEHNRLLKMWREVVAVKRSFKEMQTA------ 314
            :|||.||:..||||:.||.:::.|::.||.|...||.|||.:|||||..:|.|.:|::|      
  Rat   138 EKLTVDWSRARDELMRKESQWRMEQEFFKGYLRGEHGRLLSVWREVVTFRRHFLKMKSATDRDLT 202

  Fly   315 -MKAEVAKM-GQEINCVGKDINGSNATVAFAVQQAKRAADDELKQSQRSNDELQNQLATLKVQYE 377
             :|||.|:: |..:.|              .::...||...:...|.||::....||..|..:.:
  Rat   203 ELKAEHARLSGSLLTC--------------CLRLTLRAQSRDSSGSGRSDESEPAQLLLLVAKTQ 253

  Fly   378 SARHEIMERDQRLLELMNQ--LKK--LEDRCAQAESQAALASRYSDEIERLNNSMR---EIAQAV 435
            :...|..|:.|.|::|.:|  |:|  |:||..:..:....:.:.:.:.|.:..::|   ||.:  
  Rat   254 ALEKEAHEKSQELMQLKSQGDLEKAELQDRVTELSALLTQSQKQNKDYEEMVKALRGTMEILE-- 316

  Fly   436 VQDAENADREA----DAEVTGGVMQHM--HLTRDAASV-----VGGAGGAGSTAGGGGKSPRRNS 489
            ...||..:.||    :|:.....:||:  .:|:..|||     |....|:.::.    :|...:.
  Rat   317 TNHAELMEHEASLSRNAQEEKLSLQHVIKDITQALASVEEEDTVTQTPGSENSL----QSDYNDL 377

  Fly   490 TRASQAFAEGTISAVQAALHKYQLALHDMQVKFQNTSETLRTTKAQLETSEGTKQLLTTKMQQLT 554
            ::.........::.|.:.|.:.|.|:.|::.:.....|.:...:.|....|...:.|..::|:||
  Rat   378 SQFDSQDPNKALTLVHSVLTRRQQAVQDLRQQLSGCQEAMSFLQQQHNQWEEEGKALRERLQKLT 442

  Fly   555 EKLDSSNSKLSELLQERESLQRGLDDIRVQKQQSEMGRADINSAFENLSSDYEKMQLNCGKLQKR 619
            .:.|:       |..:...||..:|.:..:::..:..|.::....|.|..:..:::....:||.:
  Rat   443 GERDA-------LAGQTVDLQGEVDSLSKERELLQTARGELQQQLEVLEQEAWRLRRVNVELQLQ 500

  Fly   620 IDSMEEDKKAVELEIQRILKDKNITELNLRSEEDRSSRLREETISLREELNRVSLNRDLLEQQRI 684
            .||.:.:|...:.|:...::::...:..|...|.:.|....|.|:|||.|....|..:||:|::.
  Rat   501 GDSAQGEKLEQQEELHLAVRERERLQETLVGLEAKQSESLSELIALREALESSRLAGELLKQEQE 565

  Fly   685 ESDNLINLLEKQKSDLEYDLDKLLLEKCDLQEKHEKL-SNNSCSTSDELKSVQNCLQEAQEERKK 748
            |....:...|:...:|....:.|..|..||:....|| :.|.....|::...|..||..||.:..
  Rat   566 EVAAALARAEQSIVELSSSENSLKAEVADLRAAAVKLGALNEALALDKVALNQQLLQLEQENQSM 630

  Fly   749 L-RIQSVDQCN-----EIGELKKELAILDKARLELETDNLSAGE-------KLKCLQLEKEKILQ 800
            . |:::.:|..     ::.|.::....|.:.:..|||....|.|       :|:..:.|||::.:
  Rat   631 CSRVEAAEQLRSALQVDLAEAERSREALWEEKTHLETQLRKAEETGAELQAELRGAREEKEELKE 695

  Fly   801 DLACVTRDRGDIHNQLTAMCRKKEALNEELMRTRQRLEQTTETNSRLNRNLEEMVKDVEEKQVVI 865
            .|       .:.|:|       :||...:|.:..|..|:..|..:|..:..|.:|::....:|.:
  Rat   696 KL-------NEAHHQ-------QEAATAQLQQLHQDAERQEEALARAGQEKEALVRERAALEVRL 746

  Fly   866 DLHEKDTHRLNELLAALRSEKESLESVLFD----------TNTSLEA------------------ 902
            ...|:|...|.|.:..|||.||.||..||:          |.:.||.                  
  Rat   747 QAVERDRQDLAEQVLGLRSAKEQLEGNLFEAQQQNSVIQVTKSQLEVQIQTIIQAKEVIQGEVKC 811

  Fly   903 ------TEERRSQLERD------------------------------LQEALVREESLKNHVARL 931
                  ||...::.|||                              |||...:|.:|...  :|
  Rat   812 LKLELDTERSHAEQERDAVARQLAQAEQEGQAALERQKVAHEEEVNRLQEKWEKERALLQQ--KL 874

  Fly   932 QKELEQCQR---------KAQETKTQLLNAARAAE-SDFNQKIANLQACAEEAAKRHGEEILQLR 986
            .|.||..:|         :.|.|:|:.|.|.|..| :..:..:..:|...|:......|.:||  
  Rat   875 DKTLETLERERTELEMKLREQHTETEALRAQREEERTQADSALYQMQLETEKERVSLLETLLQ-- 937

  Fly   987 NALEKRMQQALQALQTAKDD-EIEKLQERLAT--LQA-------HLESLVQQHEEAL-------- 1033
              .:|.:..|.|.|:..:.| :::||:|:..|  |||       .|:..:|||.:.|        
  Rat   938 --TQKELADASQQLERLRQDMKVQKLKEQETTGMLQAQLRGAQQELKEAIQQHRDDLAAFQKDKI 1000

  Fly  1034 -IRAESEKQQALLIAHRDKQAV-----------AERLEAVSRDLKTEQESLD------------- 1073
             ::.:.|...:.|:.|.|.|.:           |:....:.::|:.|:.||.             
  Rat  1001 DLQKQVEDLTSQLVTHNDSQRLVKQEIEEKVREAQECSRIQKELEKEKASLTLSLVEKEKRLLVL 1065

  Fly  1074 ------RSRREANARDEKQRAAIAQ----LKDEMVQMRTKEEEHKIKLEECIRKQELQLSSL--R 1126
                  |.|...:.|.:.|.|...|    ::.|:::...||:|......|....:||:.|.:  |
  Rat  1066 QEADSVRQRELVSLRQDIQEAQEGQRELGVQVELLRQEVKEKEADFVAREAQLLEELEASRIAER 1130

  Fly  1127 EERESLC---RVSEELKMEIRLKEDRME-----------------STNNELQDAL---------- 1161
            :.|.||.   ..:.:|::::|..|.::|                 |..:.||.||          
  Rat  1131 QVRASLWAQEAKAAQLQLQLRSTEAQLEALVAEQQPENQAQAQLRSLYSVLQQALGSACERRPEL 1195

  Fly  1162 ---------------------RKSKEG-----------------------------EGFIDSLRK 1176
                                 |..|.|                             :...|.::|
  Rat  1196 RGGGDSVPTPWGSDPDQNGASRLLKRGPLLTALSAEAVALALQKLHQDLWKAQQARDDLRDQVQK 1260

  Fly  1177 -----------------ELTDCRRQLADSNIERDKYSGS----NKELRD---------------- 1204
                             ||.|.:|||:.|..|:.|:.|.    ..||||                
  Rat  1261 LVQRLTDTEAQKSQVHSELQDLQRQLSQSQEEKSKWEGKQNSLESELRDLHETMASLQSRLRQAE 1325

  Fly  1205 -------------------------HVKRVESAKREQARA---IEEALQKISNLEDTKN-SLENE 1240
                                     |::...:..|.||.|   :||.|:...:....|| .:|:|
  Rat  1326 LQKMEAQNDRELLQASKEKLSAQVEHLQACVTEARAQASAAGVLEEDLRTARSALKLKNEEIESE 1390

  Fly  1241 RTRLSTILKETE----------NHFTKTTQDLNATKAQLQKAQVEFAQKDEGGKELQ-------- 1287
            |.|...:.::.|          .:.|...|.|:..:.:::..|.| .|:.|..:|:|        
  Rat  1391 RERAQALQEQGELKVAQGKALQENLTLLAQTLSNREREVETLQAE-VQELEKQREMQKAALELLS 1454

  Fly  1288 ---CKLVAEVELKERAQQELCQIKKQLSDLEANLCATRQELGRARCQ-----NNQE------EHR 1338
               .|...||:|::...|||.|.:..|..|...:....|:|...|.|     |::|      ||:
  Rat  1455 LDLKKRSREVDLQQEQIQELEQCRSVLEHLPMAVQEREQKLSVQRDQIRELENDREAQRTALEHQ 1519

  Fly  1339 FHAREQELAQRLEEGRGREKRLEDQKHNLEVCLA------------------------------- 1372
            ....||: ||.:|..||:.:.|:.|...|| |||                               
  Rat  1520 LLDLEQK-AQVIESQRGQIQDLKKQLGTLE-CLALELEESHRKVEGQQKVITELEGQRELQRVAL 1582

  Fly  1373 --------DATQQIQELKARLGGAEGRIRALDEQL------------SCVELHK------RDTEQ 1411
                    :.:|::|...::|...|.....|.::|            ...||.|      :|.|:
  Rat  1583 THLTLDLEERSQELQTQSSQLHELENHSTRLAKELQERDQEVMSQRQQIEELQKQKEQLTQDLER 1647

  Fly  1412 KLSSVVHTLRRIAGIQVDGSV----------NLSHRL------LSPSRRFSPSRSCGDYDNRSTS 1460
            |...:|....||..::...::          .:.|.|      |:...:....|:   .|.:|.|
  Rat  1648 KGQELVLQKERIQVLEDQRTLQTKILEEDLEQIKHSLRERGQELASQWQLMQERA---EDGKSPS 1709

  Fly  1461 QCPDGPI----------DVDPDLVRKGVRNLMHQVAQLEREKDDYKSQLG--------------A 1501
            :...|.:          :.:.:..::.::.|...:.|||::......::|              .
  Rat  1710 KAQRGSLEHLKLILRDKEKEVECQQERIQELQEHMGQLEQQLQGLHRKVGETSLLLTHREQETAT 1774

  Fly  1502 AKKQLQDAADQ-QLRCDAKLGKLQ-------------AMLRNLQEEKSNLETDRKMKISAIQALE 1552
            .:::||:|.:| :||.....|:|:             ..||..|::....|...|.|.||:||..
  Rat  1775 LQQRLQEAKEQGELREQVLQGQLEEAQRALAQRDHELEALRQEQQQTRGQEESMKQKTSALQAAL 1839

  Fly  1553 EK----LKHRNDE-------CQMLRERLAQTEMQLAATSE-------ENGQNEERLEKSRQQCSK 1599
            |:    ||.|..|       .|.|:|.|.....|:.|..|       |:.::|:.:...:|:|::
  Rat  1840 EQAHVTLKERQGELEEHRGQVQRLQEELIVEGRQVRALEEVLGDLRAESREHEKTVLALQQRCAE 1904

  Fly  1600 L----DNEKRQLQEELAKVEGRASKLELQRVAME--------------GDLTRLQMALQEKDCSI 1646
            .    :.|.|.||:...:.:...::.|.:..|:.              |....||.||.:...::
  Rat  1905 QAQEHEAEARTLQDSWLQAQATLAEQEQELEALRAENQYSRQQEEAAFGQAEALQEALSKAQATL 1969

  Fly  1647 RQMAERLENQNRALTQLEDRCTALKSTVDQLKERLQKSAVSETQLRGEIKT-----------LQK 1700
            ::..:||..|......||.....|::|:|..:.|.::...:.....|||:|           ||:
  Rat  1970 QEKEQRLLEQAELSCTLEASTATLQATLDTCQARARQLEEALRVREGEIQTQALQHQEAMQHLQQ 2034

  Fly  1701 ELSEQGHCSQANEDKLKLVQKSL----------------QTAENEKRILTERLDSAQTNLNE--- 1746
            ||.::....:..:::.:|::|::                |..|.|.|.|.|.|...|..:.:   
  Rat  2035 ELCQKEEDLRQQDEQRQLLEKAVAQRSQENGIQEKQSLEQEKEEETRGLLESLKELQLTVAQKEE 2099

  Fly  1747 ----LRRSQQAQLDGNQR-------------------LQEQVTDLEVQRSAL-ESQLRIAKWNQE 1787
                ||.:||.|   ||.                   |.:|  |||..::|| :::.|..:|.::
  Rat  2100 EILMLREAQQRQ---NQEASSPSHRSFPAEKPSLQLLLAQQ--DLERLQNALRQTEAREIEWREK 2159

  Fly  1788 SGG-DKDLTNGNGGGNGEEELSRQLKSSQREKSELRSKLQTLQDKVKQLECDRKSKFSGGNAYDR 1851
            :.| ...|.......:..:|::..|::|..|:...:.:||  ::.|...:...:.:..|.::..|
  Rat  2160 AQGLALSLAQSKASISSLQEIAMFLQASVLERESEQQRLQ--EELVLSRQALEEQQSRGPHSSSR 2222

  Fly  1852 AEKSNSFYGGAAESGEFDSNRYDVGGGNAGGGSFNCGLDHSVIEQETRDLRLKVRRLETLLAEKE 1916
            |::... .|...|.||........|.|                  |...||.::.||:..:||.|
  Rat  2223 ADQGPK-AGQDTEPGEVIEAEPSPGVG------------------EKEQLRQRLERLQQAVAELE 2268

  Fly  1917 SELARCKARMNDSAKCHDG---------------LDGDRYRSAQMHAEKLLDARE---QSHRQQ- 1962
            .:.::        .:||:.               |..|..|:::..:   |:|||   .|..|| 
  Rat  2269 VDRSK--------LQCHNAQLRTTLEQVERERRKLKRDSLRASRAGS---LEARETMNSSPTQQD 2322

  Fly  1963 -------------VLRLENQISMLREQLAQEAKRRQQYILRSSKANREMQHLRSTLGDSLRNVSQ 2014
                         ::.|:.::::||.|||.|.|:||.||.||.:.:||:..|..:|..||..|:|
  Rat  2323 GRGSQRGSSDSMLMVELQREVALLRAQLALERKQRQDYIARSVQTSRELAGLHHSLSHSLLTVAQ 2387

  Fly  2015 HPVDPHLLESESRRLDSAVSMSL 2037
            .| :..:||:|:::||.:::.||
  Rat  2388 AP-EATVLEAETKKLDESLNQSL 2409

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RootNP_651216.2 Rootletin 110..330 CDD:464459 77/227 (34%)
Gp58 <336..>604 CDD:369586 57/285 (20%)
SMC_prok_B 503..1314 CDD:274008 230/1120 (21%)
SMC_prok_B 991..>1779 CDD:274008 243/1221 (20%)
Cep250NP_001414123.1 None

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