DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Root and Crocc

DIOPT Version :9

Sequence 1:NP_001287497.1 Gene:Root / 42860 FlyBaseID:FBgn0039152 Length:2048 Species:Drosophila melanogaster
Sequence 2:NP_742120.2 Gene:Crocc / 230872 MGIID:3529431 Length:2009 Species:Mus musculus


Alignment Length:2015 Identity:569/2015 - (28%)
Similarity:993/2015 - (49%) Gaps:272/2015 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 DPSALLRQNQELRQRLADESHSYRRRLDTYKQAQHNQANLVSRLQSKIQQYRQRCSDLEERMHET 151
            :|..|:||:.|||::|.:|..||||:|..|::.|..||.||.|||:||.||:::||:||::    
Mouse   135 EPRGLVRQSVELRRQLQEEQSSYRRKLQAYQEGQQRQAQLVQRLQAKILQYKKQCSELEKQ---- 195

  Fly   152 IKPTAGVGPKLTTGPTNQVLCSTSLTLGQSSLPCSSSLDSPPPSCSRDYVDDVLVTGGGAGAAEL 216
                               |...|..|.|..|..:..        |:| :|..|:          
Mouse   196 -------------------LMDRSTELEQQRLRDTEH--------SQD-LDSALL---------- 222

  Fly   217 CRKLEEEHQRCEQIVAQNSALRQQLEESNRTNEALTNDLQKLTNDWASLRDELLIKEDEFKEEEQ 281
              :||||.||...:...|:.||:||:::|..|:||:.|::|:|:||.....||..:|..::.||:
Mouse   223 --RLEEEQQRSASLAQVNAMLREQLDQANLANQALSEDIRKVTSDWTRSCKELEQREAVWRREEE 285

  Fly   282 AFKDYYNSEHNRLLKMWREVVAVKRSFKEMQTAMKAEVAKMGQEINCVGKDIN------------ 334
            :|..|::|||:|||::||:|:.::|...|::...:.::.::|.|:....:.:.            
Mouse   286 SFNTYFSSEHSRLLRLWRQVMGLRRQASEVKMGTERDLLQLGGELVRTSRAVQELGLGLSASLHR 350

  Fly   335 -GSNATVAFAVQ-----------QAKRAADDELKQSQRSND----ELQNQLATLKVQYESARHEI 383
             .|.|..|...|           |||...:.:|.|.|..:|    :|..::..|.:..|..:::.
Mouse   351 AESKAEAALEKQKLLQAQLEEQLQAKLLREKDLAQLQVQSDLDKADLSARVTELALSVEHLQNQN 415

  Fly   384 MERDQRLLELMNQLKKLEDRCAQAESQAALASRYSDEIERLNNSMREIAQAVVQDAENADREADA 448
            .|:||....|.::|:.||.  .:.:.|..|.   :::.|.|..::|::|||.:.|.|:..:.:.:
Mouse   416 SEKDQVNRTLSDKLEALES--LRLQEQTTLD---TEDGEGLQQTLRDLAQAALSDTESGVQLSSS 475

  Fly   449 EVTGGVMQHMHLTRDAASVVGGAGGAGST----AGGGGKSPRRNSTRASQAFAEGTISAVQAALH 509
            |.|..       |.| .|:.|.:|....|    :.|.|:||||..:.|..  ...|::.:.:|||
Mouse   476 ERTAD-------TSD-GSLRGFSGQRTPTPPRHSPGRGRSPRRGLSPACS--DSSTLTLIHSALH 530

  Fly   510 KYQLALHDMQVKFQNTSETLRTTKAQLETSEGTKQLLTTKMQQL-----------------TEKL 557
            |.||.:.||:.:::.:.|.|.:.:.||..|||.::.|..::|:|                 .::|
Mouse   531 KRQLQVQDMRGRYEASQELLGSVRKQLSDSEGERRGLEEQLQRLRDQTAASAQAQEDAQREAQRL 595

  Fly   558 DSSNSKLSELLQERESLQRGLDDIRVQKQQSEMGRADINSAFENLSSDYEKMQLNCGKLQ-KRID 621
            .|:|..||   :|:.:|...|   :|.:||::    ::....|.|.:..|:::....:|: .:.|
Mouse   596 RSANELLS---REKGNLTHSL---QVTQQQAK----ELRQELEKLQAAQEELKRQHNQLEDAQED 650

  Fly   622 SMEEDKKAVELEIQRILKDKNITELNLRSEEDRSSRLREETISLREELNRVSLNRDLLEQQRIES 686
            |::|..:| ..|::|       :...|...|.:.|.|.:|.:.:||.|:...|.||:|:.::.|.
Mouse   651 SVQEGARA-RRELER-------SHRQLEQLEVKRSGLTKELVEVREALSCAILQRDVLQTEKAEV 707

  Fly   687 DNLINLLEKQKSDLEYDLDKLLLEKCDLQEKHEKLSNNSCSTSDELKSVQNCLQEAQEERKKL-- 749
            ...:...|..::.||..|.||..|:..|::...|:|..:.|.:.:...:...:.:.:||:..|  
Mouse   708 AEALTKAEAGRAQLELSLTKLRAEEASLRDSLSKMSALNESLAQDKLELNRLIAQLEEEKVALLG 772

  Fly   750 RIQSVDQCNEIGELKKELAILDKARLELETDNLSAGEKLKCLQLEKEKILQDLACVTRDRGDIHN 814
            |.|..:....:...|:||  |::.|||.|.:.......|...:..:|.:.|.:..:..:|..:..
Mouse   773 RQQQAEHATTMAVEKQEL--LEQLRLEQEVERQGLQGSLCVAEQAREALEQQILVLRSERSHLQE 835

  Fly   815 QLTAMCRKKEALNEELMRTRQRLEQTTETNSRLNRNLEEMVKDVEEKQVVIDLHEKDTHRLNELL 879
            ||..:.|:....::||.:..:..::..|...|..|..|.|.|:.....|.:...|::...|:|..
Mouse   836 QLAQLSRQLSGRDQELEQALRESQRQVEALERAAREKEAMAKERAGLAVKLAAAEREGRTLSEEA 900

  Fly   880 AALRSEKESLESVLFDTNTSLEATEERRSQLERDLQEALVREESLKNHVARLQKELEQCQRKA-- 942
            ..||.|||:|||.|||....|...|.||.|||.|.|..|:.:|:|...:|.|::::...:.||  
Mouse   901 IRLRLEKEALESSLFDVQRQLAQLEARREQLEADSQALLLAKETLTGELAGLRQQVTSTEEKAAL 965

  Fly   943 -QETKTQ-LLNAARAAESDFNQKIANLQACAEEAAKR--HGEEI----LQLRNA-LEKRMQQALQ 998
             :|..|| |:.|.|.|::...::    :|..||..:|  |.:|.    ||...| |:.::||..:
Mouse   966 DKELMTQKLVQAEREAQASLREQ----RAAHEEDLQRLQHEKEAAWRELQAERAQLQGQLQQERE 1026

  Fly   999 ALQTAKDDEIEKLQERLATLQAHLESLVQQHEEALIRAESEKQQALLIAHRDKQAVAERLEAVSR 1063
            .|....:.|.|:|.:.:|.||       |:.:|.|:.|||||||||.:...:|.|::|:|.....
Mouse  1027 ELLARMEAEKEELSKEIAALQ-------QERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRH 1084

  Fly  1064 DLKTEQESLDRSRREANARDEKQRAAIAQLKDEMVQMRTKEEEHKIKLEECIRKQELQLSSLREE 1128
            .|......::|.:|:|.:|.|:.|..:..|..|:..:|.:.||......:.:::.|.:..:|..:
Mouse  1085 SLAAISLEMERQKRDAQSRQEQDRNTLNALTSELRDLRAQLEEATAAHAQTVKELEERTGNLGRQ 1149

  Fly  1129 RESLCRVSEELKMEIRLKEDRMESTNNELQDALRKSKEGEGFIDSLRKELTDCRRQLADSNIERD 1193
            ||:..|.:|||:.::|:.||..:....||.:|.||.::.:...::.|:|.::.||.|::...||:
Mouse  1150 REACMREAEELRTQLRVLEDTRDGLRRELLEAQRKGRDSQDSSEAHRQEASELRRSLSEGAKERE 1214

  Fly  1194 KYSGSNKELRDHVKRVESAKREQARAIEEALQKISNLEDTKNSLENERTRLSTILKETENHFTKT 1258
            ....||:|||..||:.||.:.....|.|:..||::.||:.:.|:..|...|...|:|.|....:.
Mouse  1215 ALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARVSVAKEAGELRASLQEVERSRLEA 1279

  Fly  1259 TQDLNATKAQLQKAQVEFAQKDEG--GKE---LQCKLVAEVELKERAQQELCQIKKQLSDLEANL 1318
            .::|     |..:.|::....|.|  |:|   ||.:|......::.:::|...::::|...|::|
Mouse  1280 RREL-----QELRRQMKTLDSDNGRLGRELADLQGRLALGERTEKESRREALGLRQRLLKGESSL 1339

  Fly  1319 CATRQELGRARCQNNQEEHRFHAREQELAQRLEEGRGREKRLEDQKHNLEVCLADATQQIQELKA 1383
            .|.:|||..::.:..::|..|.|||:.|...|||.||.||||.|...:||:.|.....:..||..
Mouse  1340 EALKQELQGSQRKLQEQEAEFRARERGLLGSLEEARGAEKRLLDSARSLELRLEAVRAETSELGL 1404

  Fly  1384 RLGGAEGRIRALDEQLSCVELHKRDTEQKLSSVVHTLRRIAGIQVDGSVNLSHRLLSPSRRFSPS 1448
            ||..||||.:.|:.:|:.||..:|..|.:|..:...|||..|:   |.|:     .||:|. :|:
Mouse  1405 RLSAAEGRAQGLEVELARVEAQRRVAEAQLGGLRSALRRGLGL---GRVS-----SSPARE-APA 1460

  Fly  1449 RSCGD---------YDNRSTSQCP-----DGPIDVDPDLVRKGVRNLMHQVAQLEREKDDYKSQL 1499
            ...||         |..||....|     ..|.|:||:.||..:|:.:.::...:||:|:.|.|.
Mouse  1461 GGSGDGLSSPSPLEYSPRSQPPSPGLIASPAPPDLDPEAVRDALRDFLQELRSAQRERDELKVQT 1525

  Fly  1500 GAAKKQLQDAADQQLRCDAKLGKLQAMLRNLQEEKSNLETDRKMKISAIQA----LEEKLKHRND 1560
            ....:||.:...::....::..:||..:  .:.|::....||  ::|..||    .||.::....
Mouse  1526 STLSQQLVEMEAERDHAASRAKQLQKAV--AESEEAWRSADR--RLSGAQAELALQEESVRRSKR 1586

  Fly  1561 ECQMLRERLAQTEMQLAATSEENGQNEERLEKSRQQCSKLDNEKRQLQEELAKVEGRASKLELQR 1625
            ||:...:::|..|..|.||..|...::|::.|.:...:||:::||:|:|.|...|.|:.||||||
Mouse  1587 ECRATLDQMAVLERSLQATESELRASQEKVSKMKATEAKLESDKRRLKEVLDASESRSIKLELQR 1651

  Fly  1626 VAMEGDLTRLQMALQEKDCSIRQMAERLENQNRALTQLEDRCTALKSTVDQLKERLQKSAVSETQ 1690
            .|:||:|.|.::.|.:::...:.:.:|:::..|.:...|.:...|:.||::|...|.|...||..
Mouse  1652 RALEGELQRSRLGLGDREAHAQALQDRVDSLQRQVADSEVKAGTLQLTVERLSGALAKVEESEGN 1716

  Fly  1691 LRGEIKTLQKELSEQGHCSQANEDKLKLVQKSLQTAENEKRILTERLDSAQTNLNELRRSQQAQL 1755
            ||.::::|...|::......:.:||...:||:|.|.|:::::|.||||:|:..|:|.||...:..
Mouse  1717 LRSKVQSLTDALTQSSASLSSTQDKNLHLQKALSTCEHDRQVLQERLDAARQALSEARRQSSSLG 1781

  Fly  1756 DGNQRLQEQVTDLEVQRSALESQL----RIAKWNQESGGDKDLTNGNGGGNGEEELSRQLKSSQR 1816
            :..|.|:.::..||:||...|.||    :..:..||               ||....|.::..|.
Mouse  1782 EQVQTLRGELASLELQRGDAEGQLQQLQQALRQRQE---------------GEAMALRSVQKLQE 1831

  Fly  1817 EKSELRSKLQTLQDKVKQLECDRKSKFSGGNAYDRAEKSNSFYGGAAESGEFDSNRYDVGGGNAG 1881
            |:..|:.:|.:||..:.|||.:::.          .|:|         :.:||.:|.        
Mouse  1832 ERRLLQERLGSLQRALAQLEAEKRD----------LERS---------ALQFDKDRV-------- 1869

  Fly  1882 GGSFNCGLDHSVIEQE-------TRDLRLKVRRLETLLAEKESELARCKARMND-SAKCHDGLDG 1938
              :....||.  :|:|       |..|..:..||:..|...|.:||..:.::.. .|:....|:|
Mouse  1870 --ALRKTLDK--VEREKLRSHEDTLRLNAERGRLDRTLTGAELDLAEAQQQIQHLEAQVDVALEG 1930

  Fly  1939 --------------------DRYRSAQMHAEKLLDAREQSHRQQVLRLENQISMLREQLAQEAKR 1983
                                :|.||||:..|:.|:|||::|||:|..||.|:|.|:.||.||.:|
Mouse  1931 NHNPVQPEAGEQQLELQQEVERLRSAQVQTERTLEARERAHRQRVSGLEEQVSTLKAQLHQELRR 1995

  Fly  1984  1983
            Mouse  1996  1995

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RootNP_001287497.1 Rootletin 110..332 CDD:291694 69/221 (31%)
Smc 555..1384 CDD:224117 241/847 (28%)
SMC_prok_B 991..>1779 CDD:274008 243/810 (30%)
CroccNP_742120.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 636..665 7/36 (19%)
Myosin_tail_1 703..1802 CDD:279860 330/1129 (29%)
DUF342 <984..1052 CDD:302792 20/78 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1180..1225 14/44 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1448..1501 16/58 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1957..2009 20/39 (51%)
SMC_prok_B 89..931 CDD:274008 237/874 (27%)
Rootletin 158..335 CDD:291694 69/220 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 462..519 17/66 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 575..594 0/18 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 577 1.000 Domainoid score I218
eggNOG 1 0.900 - - E1_2CMIF
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H16811
Inparanoid 1 1.050 697 1.000 Inparanoid score I673
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46615
OrthoDB 1 1.010 - - D48753at33208
OrthoFinder 1 1.000 - - FOG0001653
OrthoInspector 1 1.000 - - otm42977
orthoMCL 1 0.900 - - OOG6_106109
Panther 1 1.100 - - LDO PTHR23159
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5360
SonicParanoid 1 1.000 - - X3005
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.870

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