Protein Alignment Root and che-10

DIOPT Version :9

• Sequence 1: NP_001287497.1
• Gene: Root / 42860
• FlyBaseID: FBgn0039152
• Length: 2048
• Species: Drosophila melanogaster
• Sequence 2: NP_494819.3
• Gene: che-10 / 173801
• WormBaseID: WBGene00018051
• Length: 1955
• Species: Caenorhabditis elegans
• Alignment Length: 2208
• Identity: 457/2208 - (20%)
• Similarity: 841/2208 - (38%)
• Gaps: 598/2208 - (27%)

  Fly   101 RLADESHSYRRRLDTYKQAQHNQANLVSRLQSKIQQYRQRC-SDLEERMHETIKPTAGVG----P 160
            |:.::....|.|||...:.......::..:..::|::|||. ::..|..:.|..|...:.    |
 Worm    12 RVTEDLSECRNRLDAGIEENRRNRQVIQDINDQLQRFRQRANAESIESFNLTPSPDVTLSSLAHP 76

  Fly   161 KLT--TGPTNQVLCSTSLTLGQSSLPCSSSLDSP--------------------PPSCSRDY--- 200
            .||  ...||..:.|.::.:..:|....||..:|                    ..|...||
 Worm    77 GLTHLHNQTNISMPSLTIDIPLNSNAMISSSRTPNYAINGLRNRHKSLVGHRYRSTSPIGDYGRH 141

  Fly   201 -----------VDDVLVTGGGAGAAELCRKLEEEHQRCEQIVAQNSALRQQLEESNRTNEALTND 254
                       :|...:..|.....||..||:||..:...:...|..||::.:.:...||.|..|
 Worm   142 RSSPRVLAHYNLDGADIGVGEENLDELFAKLKEELFKNNTLEEVNEMLREENDAALAANEHLRVD 206

  Fly   255 LQKLTNDWASLRDELLIKEDEFKEEEQAFKDYYNSEHNRLLKMWREVVAVKRSFKEMQTAMKAEV 319
            ...|:.....|:.:...:...|:.|...:::...::|.:|:.:|:|..||||...|::|....::
 Worm   207 ATNLSRQLQQLQQQQHTESMRFRSENTRYRNQTETQHRKLISLWKEFTAVKRQLHELRTTTANDL 271

  Fly   320 AKMGQEI-NCVGKDINGSNATVAFAVQQAKRAADDELKQSQRSNDELQNQLATLKVQYESARHEI 383
            .:...|. .|.        ..:..|::.|::...|:.:|.:|..|::.::  ||: |..|.....
 Worm   272 DRQLTEFTRCA--------TLMRKAIRHAEQKNLDQKEQMKREKDDVLDE--TLR-QLNSVTENY 325

  Fly   384 MERDQRLLELMNQLKKLEDRCAQAESQAALASRYSDEIERLNNSMREIAQAVVQDAENADREADA 448
            |:.:::..|....||:.||.|.:...|   ....||.:|:|:....|:|
 Worm   326 MKSEEKANERQRDLKRKEDECRKLREQ---NDELSDILEQLSKMAHEMA---------------- 371

  Fly   449 EVTGGVMQHMHLTRDAASVVGGAGGAGSTAGGGGKSPRRNSTRASQAFAEGTISAVQAALHKYQL 513
                                 |..|...|.....:..|:..|..:....|...:|.||...:
 Worm   372 ---------------------GGRGRNETPMDVARKMRKLLTTKNGEIDESREAAKQAEKER--- 412

  Fly   514 ALHDMQVKFQNTSETLRTTKAQLETSEGTKQLLTTKMQQLTEKLDSSNSKLSELLQERESLQRGL 578
               |...|.....|..|....:.|....:   :.::.:...:|||....|.||.::..|..:...
 Worm   413 ---DRAKKDLEKEEKRRKDDREAERKRSS---VYSQREHDLKKLDDELRKASEKIRNLEEQRESQ 471

  Fly   579 DDIRVQKQQSEMGRADINSAFENLSSDYEKMQL-NCGKLQKRIDSMEEDKKAVELEIQRILKDKN 642
            :.:.:..|.|      :|.|........|::.: :..:|::|.||.||           .|:.|:
 Worm   472 EKLTISVQNS------LNEAHRQHKQFIEELMIRHREELKEREDSHEE-----------ALRSKD 519

  Fly   643 ITELNLRSEEDRSSR--LREETISLRE--------------ELNRVSLNRDLLEQQRIESDNLIN 691
             ||...|.|::||.|  :|.|:..|||              :|:..:|..|:||.:|   |.|..
 Worm   520 -TEERSRFEKERSEREKIRRESDELRETQRSLKGDVAAMKTDLDDKTLRLDMLETER---DELKK 580

  Fly   692 LLEKQKSDLEYDLDKLLLEKCDLQEKHEKLSNNSCSTSDELKSVQNCLQEAQEERKKLRIQSVDQ 756
            .||.::.    ..|:..||..:.:.|.::::........||...|..:...:.|.|..:.|.::.
 Worm   581 KLETERE----QADQRDLEIAECRAKLDEMAEKEAELRKELAEFQAIITAMEGEGKLNQEQFLES 641

  Fly   757 CNEIGELKKELAILDKARLELETDNLSAGEKLKCLQLEKEKILQDL--------ACVTRDRGDI- 812
            .||:..|..::..|:.   |:|..|......:..|| |||..:|::        |......|:|
 Worm   642 KNELNTLTDQIESLNS---EVENKNEEIRNLMATLQ-EKEVHIQNVRTSSHQLTATYEEANGEID 702

  Fly   813 ---------HNQLTA--------------MCRKKEALNEELMRTRQRLEQTTETNSRLNRNLEEM 854
                     |.|:..              ..||.:||.|::...:::.||       |...||||
 Worm   703 ILKAELTRLHEQVNERTRQISEANEKYDDAARKNDALLEDVATWQEKYEQ-------LKMELEEM 760

  Fly   855 VKDVEEKQVVIDLHEKDTHRLNELLAALRSEKESLESVLFDTNTSLEATEERRSQLERDLQEALV 919
            .:..:||       |::...|..||..||...:.|.:.|.....::::..|..|.|:..|.::
 Worm   761 NRRGQEK-------EREEADLRALLDDLRGNFDKLTNELKQKGVTVDSLNEEISSLKEQLNKS-- 816

  Fly   920 REESLKNHVARLQKELEQC----QRKAQETKTQLLNAARAAESDFNQKIANLQACAEEAAKRHGE 980
             |:..|..:.|:: ||||.    .::..|.|.||....|....:|.::   .:|...|..|.|
 Worm   817 -EKERKEELLRME-ELEQKNEAEMKEEYEVKLQLAEKDRQGVENFGKE---CEARMNELTKIH-- 874

  Fly   981 EILQLRNALEKRMQQALQALQTAKDDEIEKLQERLATLQAHLESLVQQHE-------EALIRAES 1038
            |:|     :|:..|..:..|.|  ::|:|:|:|:   ::..||.|.:|::       ....|.||
 Worm   875 EML-----MEEHDQLKVDHLHT--EEEVERLKEK---MRKELEKLNEQNDGDRAEWSNERNRLES 929

  Fly  1039 EKQQALLIAHRDKQAVAERLEAVSRDLKTEQESLDRSRREANARDEKQRAAIAQLKDEMVQM--- 1100
            .|.:|:    .:.|...::||.|.::.:.::.:|   ||:.....||.|    .|.|::.:|
 Worm   930 SKNEAV----TELQERVQKLEDVVKEKEDKEIAL---RRDLEDSHEKSR----DLDDKLRKMELT 983

  Fly  1101 -RTKEEEHKIKLEECIRKQELQLSSLREER------------ESLCRVS------EELKMEIRLK 1146
             ..|||:.| |.::.:.::.::|...:||.            :...|:|      |:|...|..:
 Worm   984 DEEKEEDRK-KEQKTLNEERMKLMEQKEEAMLVATKHATTIDQQTRRISVLEGDVEKLTAGIAER 1047

  Fly  1147 EDRMESTNNELQDALRKSKEGEGFIDSLRKELTDCRRQLADSNIERDKYSGSNK--ELRDHVKRV 1209
            |..:.:..:...:.:.|.:..|..::.|:.||....:|  :|.::..|...|.|  |.|..::.:
 Worm  1048 ESSINALESNTMELISKLETTEAELEKLKDELAVMLKQ--NSELKNGKEGLSEKWNEERKKIQDL 1110

  Fly  1210 ESAKREQARAIEEALQKISNLEDTKNSLENERTRLSTILKETENHFTKTTQDLNATKAQLQKAQV 1274
            ....||..:.:.....|..|||:.||.|:...|                  ||.....||:...:
 Worm  1111 ADQLREANKVVHNMRMKNVNLEEKKNELDQNVT------------------DLTNKVRQLEIQLM 1157

  Fly  1275 EFAQKDEGGKELQCKLVAEVE-LKERAQQELCQIKKQLSDLEANLCATRQELGRARCQNNQE--- 1335
            :.|.|:|...:|..|:..:.: :.::||.|    :.:|:|||        ::.:|....||.
 Worm  1158 DKAAKNEVSGDLLRKMEHDAQSMLKQAQNE----QFRLTDLE--------KVRKALQDENQRLVN 1210

  Fly  1336 ---------EHRFHAREQELAQRLEEGRGREKR-----LEDQKHNLEVCLADATQQIQELKA--- 1383
                     |.:....:..::..|::.|..|::     |::|:...::.......:.|||||
 Worm  1211 DLATVKAAFEVKRETSKSAISDILDKYRSAEEKANKGELDNQRLRSDLATVTLKLERQELKAKDS 1275

  Fly  1384 --RLGGAEGRIRALDEQLSCVELHKRDTEQKLSSVVHTLRRIAGIQVD-----GSVNLSHR---- 1437
              ||..::.|...:..:|:  .|.|...|...:.:....|:...|.||     .|:.|:..
 Worm  1276 DNRLRDSQKRFEEVQSKLA--NLQKSAVESLQNPMSSNSRQNRSIYVDIPRAASSIGLNENSDEV 1338

  Fly  1438 --LLSPSRRFSPSRSCGDYDNRSTSQCPDGPIDVDPDLVRKGV--RNLMHQVAQLEREKDDYKSQ 1498
              ..|||.||:        |:....|.....:||...:   ||  |.|..::.|||.:..|....
 Worm  1339 PLRSSPSVRFA--------DSSQNMQRAVDSMDVSSSV---GVTLRFLKERIEQLEADNADLSDA 1392

  Fly  1499 LGAAKKQL----QDAADQQLRCDAKLGKLQAMLRNLQEEKSNLET-------------------- 1539
            |..||.:|    :..||:|:    .:.:::..|.::.||::.:|.
 Worm  1393 LEKAKDELRQRNEKLADRQM----VIERVERQLVHITEERNTIENRMTSQRQMYLTNEESSRSRE 1453

  Fly  1540 ----DRKMKISAIQ----ALEEKLKHRNDECQMLRERL--------------------------- 1569
                ..|.:||.::    ..|.||.|...|.::|..:|
 Worm  1454 HEIRSMKARISTLELHLREKESKLAHLRKEIEVLHGQLHDALESKEKATGLVGVQDSKHRDLEEQ 1518

  Fly  1570 ---AQTEMQLAATSEEN--GQNE------ERLEKSRQQCSKLDNEKRQLQE------ELAKVEGR 1617
               |..|.:||...:..  .:||      |:|||.|:|..:...::|:|.|      |..:|..|
 Worm  1519 LDRANRERELAIGKQRRTLAENENLFRKLEQLEKEREQLMREITDERRLNERNRTSLEELRVSER 1583

  Fly  1618 ASKL----------ELQRVAME--------GDLTRLQMALQEKDCS-IR-QMAERLENQN----- 1657
            ..|.          |.:|...|        .::|....|| .|:|. :| :|.::|...|
 Worm  1584 TWKSAMTTAKKPAEEQERAVQEQRRWEESNHEMTNRNTAL-TKECDRLRVEMRDQLNRMNGINLR 1647

  Fly  1658 -----RALTQLEDRCTALKSTVDQLKERLQKSAVSETQLRGEIKTLQKELSEQGHCSQANEDKLK 1717
                 |...:|..:...:::||..:|:..::....|.::|.|:|.|:||
 Worm  1648 SVDFERKNEELSSKLIVMQNTVTAMKKFEEEWKRLEAEMRAELKILRKE---------------- 1696

  Fly  1718 LVQKSLQTAENEKRILTERLDSAQTNLNELRR------SQQAQLDG-NQRLQEQVTDLEVQRSAL 1775
               |.:||||                :.:|:|      :::.:::| ..||:.:::.|:....||
 Worm  1697 ---KLMQTAE----------------IEDLKRKSFRSDTEKKEIEGIRVRLEREISALKRHVDAL 1742

  Fly  1776 ESQLRIAKWNQESGGDKDLTNGNGGGNGEEELSRQLKSSQREKSELRSKLQTLQDKVKQLECDRK 1840
            |.:    |...|....:.:       |....:.:.|.|.:||..:|......||.:::.||.|
 Worm  1743 EEE----KGKTEKAVRETM-------NERRAIDKSLASMERENQQLYRNCAQLQAQIQNLERD-- 1794

  Fly  1841 SKFSGGNAYDRAEKSNSFYGGAAESGEFDSNRYDVGGGNAGGGSFNCGLDHSVIEQETRDLRLKV 1905
               :|..:..:..|                                   :||::|.....|..:.
 Worm  1795 ---AGNRSVTKLAK-----------------------------------EHSLLEARIAALIEEK 1821

  Fly  1906 RRLETLLAEKESELARCKARMNDSAKCHDGLDGDRYRSAQMHAEKLLDAREQSHRQQVLRLENQI 1970
            |:|:::|.:|::                                      ..||::::  ||:||
 Worm  1822 RQLQSMLDQKDA--------------------------------------NYSHKRKL--LESQI 1846

  Fly  1971 SMLREQLAQEAKRRQQYILRS--SKANREMQHLRSTLGDSLRNVSQHPVDPH--LLESESRRL 2029
            .:|||||..|.::|.:.::.:  :.:.|.:||         .:..:|.::.|  |.:|..|.:
 Worm  1847 QLLREQLEAERRKRTKGVVATGPTVSRRGVQH---------TSAFRHTIERHRSLSQSSERTI 1900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Root	NP_001287497.1	Rootletin	110..332	CDD:291694	55/263 (21%)
		Smc	555..1384	CDD:224117	211/935 (23%)
		SMC_prok_B	991..>1779	CDD:274008	203/967 (21%)
che-10	NP_494819.3	Rootletin	<164..282	CDD:317452	28/117 (24%)
		SMC_N	<294..797	CDD:330553	128/597 (21%)
		SMC_N	568..>1297	CDD:330553	181/818 (22%)
		SMC_N	1029..1791	CDD:330553	176/857 (21%)
		ClpB_D2-small	<1766..>1856	CDD:331348	31/169 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001653
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23159
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.100