DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Root and Cep250

DIOPT Version :9

Sequence 1:NP_001287497.1 Gene:Root / 42860 FlyBaseID:FBgn0039152 Length:2048 Species:Drosophila melanogaster
Sequence 2:NP_001123472.1 Gene:Cep250 / 16328 MGIID:108084 Length:2435 Species:Mus musculus


Alignment Length:2558 Identity:589/2558 - (23%)
Similarity:1000/2558 - (39%) Gaps:775/2558 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    98 LRQRLADESHSYRRRLDTYKQAQHNQANLVSRLQSKIQQYRQRCSDLEERMHETIKPTAGVGPKL 162
            |:|::|:...:..|:|...::||..||.||.:||:|:.|||..|.|||:|    ::.|.|:.|:.
Mouse    26 LQQQMAENQAASWRKLKNSQEAQKRQATLVRKLQAKVLQYRSWCQDLEKR----LEATGGLIPQR 86

  Fly   163 TTGPTNQVLCSTSLTLGQSSLPCSSSLDSPPPSCSRDYVDDVLVTGGGAGAAELCRKLEEEHQRC 227
            .                       .|::.|                   ...:|..:||||.|||
Mouse    87 W-----------------------ESVEEP-------------------NLEQLLIRLEEEQQRC 109

  Fly   228 EQIVAQNSALRQQLEESNRTNEALTNDLQKLTNDWASLRDELLIKEDEFKEEEQAFKDYYNSEHN 292
            |.:|..|:.||..:|:::..|:||..|::|||.||:..||||:.||.:::.|::.||.|...||.
Mouse   110 ESLVEVNTELRLHMEKADVVNKALQEDVEKLTVDWSRARDELVRKESQWRMEQEFFKGYLRGEHG 174

  Fly   293 RLLKMWREVVAVKRSFKEMQTA-------MKAEVAKM-GQEINCVGKDINGSNATVAFAVQQAKR 349
            |||.:|||||..:|.|.:|::|       :|||.|:: |..:.|              .::...|
Mouse   175 RLLNLWREVVTFRRHFLKMKSATDRDLTELKAEHARLSGSLLTC--------------CLRLTLR 225

  Fly   350 AADDELKQSQRSNDELQNQLATLKVQYESARHEIMERDQRLLELMN--QLKK--LEDRCAQAESQ 410
            |...|...|.|:.:....:|..|..:.::...|..|:.|.|::|.:  .|:|  |:||..:..:.
Mouse   226 AQSRESSGSGRTEESEPARLLLLVAKTQALEKEAHEKSQELMQLKSHGDLEKAELQDRVTELSAL 290

  Fly   411 AALASRYSDEIERLNNSMREIAQAV-VQDAENADREAD------------AEVTGGVMQHMHLTR 462
            ...:.:.:::.|::..::||..:.: ...||..:.||.            .:|...:.|.:....
Mouse   291 LTQSQKQNEDYEKMVKALRETMEILETNHAELMEHEASLSRNAQEEKLSLQQVIKAITQALASVE 355

  Fly   463 DAASVVGGAG---GAGSTAGGGGKSPRRNSTRASQAFAEGTISAVQAALHKYQLALHDMQVKFQN 524
            :..:|...:|   ...|...|..:...::..||        ::.||:.|.:.|.|:.|::.:...
Mouse   356 EEDTVTQSSGHEDSLQSDCNGLSQFDPQDPDRA--------LTLVQSVLTRRQQAVQDLRQQLSG 412

  Fly   525 TSETLRTTKAQLETSEGTKQLLTTKMQQLTEKLDSSNSKLSELLQERESLQRGLDDIRVQKQQSE 589
            ..|.:...:.|.:..|...:.|..|:|:||.:.|:       |..:...||..:|.:..::....
Mouse   413 CQEAMSFLQQQHDQWEEEGRALREKLQKLTGERDA-------LAGQTVGLQGEVDSLTGERDALA 470

  Fly   590 MGRADINSAFENLSSDYEKMQLNCGKLQKRIDSMEED-----KKAVELEIQ------RILKDKNI 643
            ....|:....::||.:.|.:|...|:||::::.:|::     :..:||::|      ..|:.:..
Mouse   471 GQTVDLQGEVDSLSRERELLQKARGELQQQLEVLEQEAWRLRRMNMELQLQGDSAQGEKLEQQEE 535

  Fly   644 TELNLRSEEDRSSRLRE--------------ETISLREELNRVSLNRDLLEQQRIE--------S 686
            ..|.:|..|    ||:|              |.::|||.|....|..:||:|:|:|        .
Mouse   536 LHLAVRERE----RLQETLVGLEAKQSESLSELLTLREALESSRLEGELLKQERVEVAAALARAE 596

  Fly   687 DNLI------NLLEKQKSDLEYDLDK-------LLLEKCDLQE---KHEKLSNNSCSTSDELKSV 735
            .:::      |.|:.:.:||.....|       |.|:|.:|.:   :.|:.:.:.||..:..:.:
Mouse   597 QSIVELSGSENSLKAEVADLRAAAVKLGALNEALALDKVELNQQLLQLEQENQSLCSRVEAAEQL 661

  Fly   736 QNCLQ----EAQEER-----KKLRIQS-VDQCNEIG-ELKKEL--------AILDK--------- 772
            ::.||    ||:..|     ||.:::: :.:..|.| ||:.||        .:.||         
Mouse   662 RSALQVDLAEAERRREALWEKKTQLETQLQKAEEAGAELQAELRGTREEKEELKDKLSEAHHQQE 726

  Fly   773 ---ARLE-LETDNLSAGEKLKCLQLEKEKILQD-------LACVTRDRGDIHNQLTAMCRKKEAL 826
               |.|| |..|.....|.|.....|||.::::       |..|.|||.|:...:..:...||.|
Mouse   727 TATAHLEQLHQDAERQEETLARAVQEKEALVRERAALEVRLQAVERDRQDLTEHVLGLRSAKEQL 791

  Fly   827 NEELMRTRQRLEQTTETNSRLNRNLEEMVK----------------DVE---------------- 859
            ...|...:|:......|..:|...::.:::                |.|                
Mouse   792 ESNLFEAQQQNSVIQVTKGQLEVQIQTIIQAKEVIQGEVKCLKLELDAERTRAEQEWDAVARQLA 856

  Fly   860 ----------EKQVVIDLHEKDTHRLNE---------------LLAALRSEKESLESVLFDTNTS 899
                      |:|.|  .||::.:||.|               .|..|..|:..||:.|.:..|.
Mouse   857 QAEQEGQASLERQKV--AHEEEVNRLQEKWEKERSWLQQELDKTLETLERERAELETKLREQQTE 919

  Fly   900 LEA----TEERRSQLERDLQEALVREE----SLKNHVARLQKEL----EQCQRKAQETKTQLLNA 952
            :||    .||.|||.:..|.:..:..|    ||...:.|.||||    :|.:|..|:.|.|.|. 
Mouse   920 MEAIRAQREEERSQADSALYQMQLETEKERVSLLETLLRTQKELADASQQLERLRQDMKIQKLK- 983

  Fly   953 ARAAESDFNQKIANLQACAEEAAKRHGEEI-------LQLRNALEKRMQQALQALQTAKDD---- 1006
            .:........::...|...:|||::|.:::       |.|:..:|..|.|.:     |.||    
Mouse   984 EQETTGMLQAQLQETQQELKEAAQQHRDDLAAFQKDKLDLQKQVEDLMSQLV-----AHDDSQRL 1043

  Fly  1007 ---EIE---KLQERLATLQAHLE--------SLVQQHEEALI--RAESEKQQALLIAHRDKQAVA 1055
               |||   |:.:..:.:|..||        |||::.:..||  .|:|.:||.|....:|.|...
Mouse  1044 VKEEIEEKVKVAQECSRIQKELEKENASLALSLVEKEKRLLILQEADSVRQQELSSLRQDIQEAQ 1108

  Fly  1056 ERLEAVSRDLKTEQESLDRSRREANARDEKQRAAIAQLKDEMVQMRTKEEEHKIKL--EEC---- 1114
            |.    .|:|..:.|.|   |:|...::....|..|||.:|:...|..|::.:..|  :|.    
Mouse  1109 EG----QRELGVQVELL---RQEVKEKEADFVAREAQLLEELEASRVAEQQLRASLWAQEAKATQ 1166

  Fly  1115 ----IRKQELQLSSLREERE----------SLCRVSE-------ELKMEIR-------------- 1144
                :|..|.||.:|..|::          |||.|.:       |.:.|:|              
Mouse  1167 LQLQLRSTESQLEALVAEQQPENQAQAQLASLCSVLQQALGSACESRPELRGGGDSAPTLWGPDP 1231

  Fly  1145 -----------------------------LKED--RMESTNNELQDALRK----SKEGEGFIDSL 1174
                                         |.:|  :.....::|:|.::|    ..:.|.....:
Mouse  1232 DQNGASRLFKRWSLPTALSPEAVALALQKLHQDVWKARQARDDLRDQVQKLVQRLTDTEAQKSQV 1296

  Fly  1175 RKELTDCRRQLADSNIERDKYSGS----NKELRD----------HVKRVESAKRE---------- 1215
            ..||.|.:|||:.|..|:.|:.|.    ..||||          .:::.|..|.|          
Mouse  1297 HSELQDLQRQLSQSQEEKSKWEGRQNSLESELRDLHETAASLQSRLRQAELQKMEAQNDRELLQA 1361

  Fly  1216 -------------------QARA-----IEEALQKISNLEDTKN-SLENERTRLSTILKETE--- 1252
                               ||:|     :||.|:...:....|| .||:||.|...:.::.|   
Mouse  1362 SKEKLSAQVEHLQACVAEAQAQADAAAVLEEDLRTARSALKLKNEELESERERAQALQEQGELKV 1426

  Fly  1253 -------NHFTKTTQDLNATKAQLQKAQVEFAQKDEGGKELQ-----------CKLVAEVELKER 1299
                   .:.....|.|:..:.:::..|.| .|:.|..:|:|           .|...||:|::.
Mouse  1427 AQGKALQENLALLAQTLSNREREVETLQAE-VQELEKQREMQKAALELLSLDLKKRSREVDLQQE 1490

  Fly  1300 AQQELCQIKKQLSDLEANLCATRQELGRARCQ-----NNQE------EHRFHAREQELAQRLEEG 1353
            ..|||.|.:..|..|...:....|:|...|.|     |::|      ||:....||: ||.:|..
Mouse  1491 QIQELEQCRSVLEHLPMAVQEREQKLSVQRDQIRELENDREAQRSVLEHQLLDLEQK-AQVIESQ 1554

  Fly  1354 RGREK--------------RLEDQKHNLE-----------------VCLADATQQIQELKARLGG 1387
            ||:.:              .||:..|.:|                 |.|...|..::|....|..
Mouse  1555 RGQIQDLKKQLGTLECLALELEESHHKVESQQKMITELEGQREMQRVALTHLTLDLEERSQELQA 1619

  Fly  1388 AEGRIRALDEQLS--CVELHKRDTE-----QKLSSVVHTLRRIA---------------GIQV-- 1428
            ...::..|:...:  ..||.:||.|     |::..:.....::|               .|||  
Mouse  1620 QSSQLHELENHSTHLAKELQERDQEVTSQRQQIDELQKQQEQLAQALERKGQELVLQKERIQVLE 1684

  Fly  1429 -----------DGSVNLSHRLLSPSRRFSPS----RSCGDYDNRSTSQCPDGPI----------D 1468
                       :....:.|.|...|:..:..    ....| |.:|.|:...|.:          :
Mouse  1685 DQRTLQTKILEEDLEQIKHSLRERSQELASQWQLVHERAD-DGKSPSKGQRGSLEHLKLILRDKE 1748

  Fly  1469 VDPDLVRKGVRNLMHQVAQLEREKDDYKSQLG--------------AAKKQLQDAADQ-QLRCDA 1518
            .:.:..::.::.|...:.|||::......::|              ..::.||:|.:| :||...
Mouse  1749 KEVECQQERIQELQGHMGQLEQQLQGLHRKVGETSLLLTHREQETATLQQHLQEAKEQGELREQV 1813

  Fly  1519 KLGKLQAMLRNLQEEKSNLETDR-------------KMKISAIQALEEK----LKHRNDECQMLR 1566
            ..|:|:...|:|.:....|||.|             |:|.||:||..|:    ||.|..|.:..|
Mouse  1814 LQGQLEEAQRDLAQRDHELETLRQEKQQTQDQEESMKLKTSALQAALEQAHATLKERQGELEEHR 1878

  Fly  1567 E--RLAQTEM-----QLAATSE-------ENGQNEERLEKSRQQCSKL----DNEKRQLQ----- 1608
            |  |..|.|:     |:.|..|       |:.::|:.:...:|:|::.    :.|.|.||     
Mouse  1879 EQVRRLQEELEVEGRQVRALEEVLGDLRAESREHEKAVLALQQRCAEQAQEHEAEARTLQDSWLQ 1943

  Fly  1609 ---------EELA--KVEGRASKLE-----LQRVAMEGDLTRLQMALQEKDCSIRQMAE---RLE 1654
                     :|||  :.|.:.|:.:     .|..|::..|::.|.|||||:.|:.:.||   .||
Mouse  1944 AQATLTEQEQELAALRAENQYSRRQEEAAVSQAEALQEALSKAQAALQEKEQSLLEQAELSHTLE 2008

  Fly  1655 NQNRALTQLEDRCTA---------------------------------LKSTVDQLKERLQKSAV 1686
            ....||....|.|.|                                 |....::|::.|:|:..
Mouse  2009 ASTAALQATLDTCQASARQLEEALRIREGEIQAQALQHHEVTQHLQQELCQKKEELRQLLEKAGA 2073

  Fly  1687 SETQLRG--EIKTLQKELSEQGHCSQANEDKLKLVQKSLQTAENEKRIL---------------- 1733
            ..:|..|  |.::|::|..|:   ::...:.||.:|  |..|:.|:.||                
Mouse  2074 RRSQENGIQEKQSLEQERQEE---TRRLLESLKELQ--LTVAQREEEILMLREASSPRHRALPAE 2133

  Fly  1734 ------------TERLDSA--QTNLNELRRSQQAQ------------LDGNQR----LQEQVTDL 1768
                        .|||.:|  ||...|:...::||            :...|.    ||..|.:.
Mouse  2134 KPALQPLPAQQELERLQTALRQTEAREIEWREKAQDLALSLAQSKASISSLQEITMFLQASVLER 2198

  Fly  1769 EVQRSALESQL---RIAKWNQESGGDKDLTNGNGG---GNGEE--ELSRQLKSSQREKSELRSKL 1825
            |.::..|:.:|   |.|...|:|||....:..:.|   |.|.:  |:..:......||..|..:|
Mouse  2199 ESEQQRLQEELVLSRQALEEQQSGGPHSTSRADQGPKVGQGSQSGEVETEPSPGVEEKERLTQRL 2263

  Fly  1826 QTLQDKVKQLECDRKSKFSGGNAYDRAEKSNSFYGGAAESGEFDSNRYDVGGGNAGGGSFNCGLD 1890
            :.||..|.:||.|| ||....||..|                                       
Mouse  2264 ERLQQAVAELEVDR-SKLQCHNAQLR--------------------------------------- 2288

  Fly  1891 HSVIEQETRDLRLKVRRLETLLAEKESELARCKARMNDSAKCHDGLDGDRYRSAQMHAEKLLDAR 1955
             :.:||..|: |.|::| :::.|.:...| ..:..|..|....||      |.:|         |
Mouse  2289 -TALEQVERE-RRKLKR-DSVRASRAGSL-EARETMTSSPTQQDG------RGSQ---------R 2334

  Fly  1956 EQSHRQQVLRLENQISMLREQLAQEAKRRQQYILRSSKANREMQHLRSTLGDSLRNVSQHPVDPH 2020
            ..|....|:.|:.::::||.|||.|.|:||.||.||.:.:||:..|..:|..||..|:|.| :..
Mouse  2335 GSSDSVLVVELQREVALLRAQLALERKQRQDYIARSVQTSRELAGLHHSLSHSLLTVAQAP-EAT 2398

  Fly  2021 LLESESRRLDSAVSMSL-PPSSC 2042
            :||:|:|:||.:::.|| .|..|
Mouse  2399 VLEAETRKLDESLNQSLTSPGPC 2421

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RootNP_001287497.1 Rootletin 110..332 CDD:291694 77/229 (34%)
Smc 555..1384 CDD:224117 263/1200 (22%)
SMC_prok_B 991..>1779 CDD:274008 254/1199 (21%)
Cep250NP_001123472.1 Rootletin 39..214 CDD:373494 75/220 (34%)
SMC_prok_A <228..>507 CDD:274009 58/293 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 356..384 4/27 (15%)
Smc 475..1164 CDD:224117 167/707 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 693..728 8/34 (24%)
SMC_prok_B 865..1547 CDD:274008 162/697 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1212..1233 2/20 (10%)
SMC_prok_B <1268..2070 CDD:274008 169/804 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1290..1324 11/33 (33%)
DUF3584 <1874..>2420 CDD:378817 149/610 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2071..2092 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2215..2259 11/43 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2296..2338 13/59 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2411..2435 4/11 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167836421
Domainoid 1 1.000 121 1.000 Domainoid score I5684
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D48753at33208
OrthoFinder 1 1.000 - - FOG0001653
OrthoInspector 1 1.000 - - otm42977
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23159
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X3005
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
98.910

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