DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Root and JMY

DIOPT Version :9

Sequence 1:	NP_001287497.1	Gene:	Root / 42860	FlyBaseID:	FBgn0039152	Length:	2048	Species:	Drosophila melanogaster
Sequence 2:	NP_689618.4	Gene:	JMY / 133746	HGNCID:	28916	Length:	988	Species:	Homo sapiens

Alignment Length:	1166	Identity:	233/1166 - (19%)
Similarity:	405/1166 - (34%)	Gaps:	377/1166 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   443 DREADAEVTGGVMQHMHLTRDAASVVGG--AGGAGSTAGGGGKSP---------------RRNST 490
            :|.|..:.:|        :|:.|...||  ||||.|....|..||               |....
Human    48 NRTAQRQRSG--------SREQAGARGGAEAGGAASDGSRGPGSPAGRGRPEATASATLVRSPGP 104

  Fly   491 RASQAFAEGTISAVQAALHKYQLALHDMQVKFQNTSETLRTTKAQLETSEGTKQLLTTKM----- 550
            |.|.|:|||...                    ::|...|...:.:...|:|.:..|.:.:
Human   105 RRSSAWAEGGSP--------------------RSTRSLLGDPRLRSPGSKGAESRLRSPVRAKPI 149

  Fly   551 --QQLTEKLDSSNSKLSELLQERESLQRGLDDIRVQKQQSEMGRADINSAFENLSSDYEKMQLNC 613
              |:.:|..|::.:..:.              .|...:::::....|.||...:|.:.|.:::
Human   150 PGQKTSEADDAAGAAAAA--------------ARPAPREAQVSSVRIVSASGTVSEEIEVLEM-- 198

  Fly   614 GKLQKRIDSMEEDKKAVELEIQRILKDKNITELNLRSEEDRSSRLREETISLREELNRVSLNRDL 678
                     ::||:  ..|.:....:....|||...:||
Human   199 ---------VKEDE--APLALSDAEQPPPATELESPAEE-------------------------- 226

  Fly   679 LEQQRIESDNLINLLEKQKSDLEYDLDKLLLEKCDLQEKHEKLSNNSCSTSDELKSVQNCLQEAQ 743
                    .:...|...|                ||:..|::|    ||.:.:|   :.||....
Human   227 --------CSWAGLFSFQ----------------DLRAVHQQL----CSVNSQL---EPCLPVFP 260

  Fly   744 EERKKLRIQSVDQCNEIGELKKELAILDKARLELETDNLSAGEKLKCLQLEKE----------KI 798
            ||...:.........|:              .|.|.|.|       |.||:..          ||
Human   261 EEPSGMWTVLFGGAPEM--------------TEQEIDTL-------CYQLQVYLGHGLDTCGWKI 304

  Fly   799 L-QDLACVTRDRGDIHNQLTAMCRKKEALNEELMRTRQRLEQTTETNSRLNRNLEEMVKDVEEKQ 862
            | |.|...|.|..:.:..|:.:  :::...|.|.|.|:|:::
Human   305 LSQVLFTETDDPEEYYESLSEL--RQKGYEEVLQRARKRIQE----------------------- 344

  Fly   863 VVIDLHEKDTHRLNELLAALRSEKESLESVLFDTNTSLEATEERRSQL---ERDLQE-ALVREES 923
             ::|.| |:|..:.|||...:.|.|:..|:       .|||.|....|   .||::| |::|.:.
Human   345 -LLDKH-KNTESMVELLDLYQMEDEAYSSL-------AEATTELYQYLLQPFRDMRELAMLRRQQ 400

  Fly   924 LK----------NHVARLQKELEQCQRKAQ------------------ETKTQLLNAARAAESDF 960
            :|          ..:..||||....||||.                  :.:..:.:..||.:..|
Human   401 IKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKF 465

  Fly   961 NQKIANLQACAEEAAKRH---GEEILQLRNALEKRMQQALQALQTAKDDEIEKLQ------ERLA 1016
            .:  |:..|.||...|..   .:|.||:..|.|..::|...||:    :|::.|:      .||.
Human   466 GK--ASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRKHALK----EEMQSLRGGTEAIARLD 524

  Fly  1017 TLQAHLESL----------VQQHEEALIRAESEKQQALLIAHRDK----------QAVAERLE-A 1060
            .|:|....|          :.:.||.|:.|:.|..:.|:...||:          :|:.|:.| |
Human   525 QLEADYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMA 589

  Fly  1061 VSRDLKTEQ-ESLDRSRREANARDEKQRAAIAQLK----------DEMVQMRTK-EEEHKIKLEE 1113
            .|..|:.|: :.|.:..|:..||..:..|..:.|:          :|.:|.||: |:|::.....
Human   590 ASAYLQREELQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTV 654

  Fly  1114 CIRKQELQLSSLREERESLCRVSEELKMEIRLKEDRMESTNNELQDALRKSKE---GEGFIDSLR 1175
            .:::::|.   ..|||:| ..||:|.:..:               |.||..|:   |:..:.|.|
Human   655 QLKREKLH---DEEERKS-AWVSQERQRTL---------------DRLRTFKQRYPGQVILKSTR 700

  Fly  1176 KELTDCRRQLADSNIERDKYSGSNKELRDHVKRVES-----AKREQARAIEEALQKISNLEDTK- 1234
            ..|...||:.|.|.:.::.:..|...:....::.|.     .||..::..|.  |.:..||||.
Human   701 LRLAHARRKGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEP--QSLVQLEDTSL 763

  Fly  1235 NSLENERTRLSTILKE---------TENHFTKTTQDLNATKAQLQKA--------------QVEF 1276
            ..||.....||.:..|         ..|:....:..:|...:.|...              .:..
Human   764 TQLEATSLPLSGVTSELPPTISLPLLNNNLEPCSVTINPLPSPLPPTPPPPPPPPPPPPPPPLPV 828

  Fly  1277 AQKDEGGKELQCKLVAEVELKERAQQELCQIKKQLSDLEANLCATRQELGRARCQNNQEEHRFHA 1341
            | ||.|.:.|:..|..:...::|..:........|.| .:.|.:.|::|  .:.....:..|..:
Human   829 A-KDSGPETLEKDLPRKEGNEKRIPKSASAPSAHLFD-SSQLVSARKKL--RKTAEGLQRRRVSS 889

  Fly  1342 REQELAQRLEEGRGREKRL----------EDQKHNLEVCLADATQQIQELKARLGGAEGRIRALD 1396
            ...|:...|:.|....|::          ||..:|:   ||...:.::..|.:..       .|.
Human   890 PMDEVLASLKRGSFHLKKVEQRTLPPFPDEDDSNNI---LAQIRKGVKLKKVQKD-------VLR 944

  Fly  1397 EQLSCVELHKRDTEQKLSSVVHTLRRIAGIQVDGSVNLSHRLLSP-SRRFSPSRSCGDYDN 1456
            |..:.:.    ||:....|:...||||             :..|| |.....:..|.|::|
Human   945 ESFTLLP----DTDPLTRSIHEALRRI-------------KEASPESEDEEEALPCTDWEN 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Root	NP_001287497.1	Rootletin	110..332	CDD:291694
		Smc	555..1384	CDD:224117	190/955 (20%)
		SMC_prok_B	991..>1779	CDD:274008	113/548 (21%)
JMY	NP_689618.4	Interaction with p300/EP300. /evidence=ECO:0000250	1..126		24/105 (23%)
		WHAMM-JMY_N	6..54	CDD:292542	2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..178		30/168 (18%)
		JMY	229..582	CDD:292496	94/436 (22%)
		Interaction with p300/EP300. /evidence=ECO:0000250	478..567		22/92 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	731..755		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	800..865		11/66 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	967..988		6/33 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000