DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Root and CEP250

DIOPT Version :9

Sequence 1:NP_001287497.1 Gene:Root / 42860 FlyBaseID:FBgn0039152 Length:2048 Species:Drosophila melanogaster
Sequence 2:NP_009117.2 Gene:CEP250 / 11190 HGNCID:1859 Length:2442 Species:Homo sapiens


Alignment Length:2534 Identity:534/2534 - (21%)
Similarity:975/2534 - (38%) Gaps:732/2534 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    98 LRQRLADESHSYRRRLDTYKQAQHNQANLVSRLQSKIQQYRQRCSDLEERMHETIKPTAGVGPKL 162
            |:|::|:...:..|:|...::||..||.||.:||:|:.|||..|.:||:|:            :.
Human    27 LQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRL------------EA 79

  Fly   163 TTGPTNQVLCSTSLTLGQSSLPCSSSLDSPPPSCSRDYVDDVLVTGGGAGAAELCRKLEEEHQRC 227
            |.||..|..               .:::.|       .:|::||            :||||.|||
Human    80 TGGPIPQRW---------------ENVEEP-------NLDELLV------------RLEEEQQRC 110

  Fly   228 EQIVAQNSALRQQLEESNRTNEALTNDLQKLTNDWASLRDELLIKEDEFKEEEQAFKDYYNSEHN 292
            |.:...|:.||..:|:::..|:||..|::|||.||:..||||:.||.:::.|::.||.|...||.
Human   111 ESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHG 175

  Fly   293 RLLKMWREVVAVKRSFKEMQTAMKAEVAKMGQEINCVGKDINGSNATVAFAVQQAKRAADDELKQ 357
            |||.:|||||..:|.|.||::|...::.::..|      .:..|.:.:...::....|...|...
Human   176 RLLSLWREVVTFRRHFLEMKSATDRDLMELKAE------HVRLSGSLLTCCLRLTVGAQSREPNG 234

  Fly   358 SQRSNDELQNQLATLKVQYESARHEIMERDQRLLELMNQ--LKK--LEDRCAQAESQAALASRYS 418
            |.|.:.....||..|..:.:....|..||.|.|::|.:|  |:|  |:||..:..:....:.:.:
Human   235 SGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQN 299

  Fly   419 DEIERLNNSMREIAQAVVQDAENADREADAEVTGGVMQH----MHLTRDAASVVGGAGGAGSTAG 479
            ::.|::..::||..: :::.......|.:|.::....:.    ..:.:|...|:...|...:...
Human   300 EDYEKMIKALRETVE-ILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGS 363

  Fly   480 GGGKSPRRNSTRASQ---AFAEGTISAVQAALHKYQLALHDMQVKFQNTSETLRTTKAQLETSEG 541
            |...|...:|:..||   ..|:..::.|::.|.:.:.|:.|::.:.....|.:...:.|.:..|.
Human   364 GHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEE 428

  Fly   542 TKQLLTTKMQQLTEKLDS-------SNSKLSELLQERESLQRGLDDIRVQKQQSEMGRADINSAF 599
            ..:.|..::|:||.:.|:       ...::..|.:|||.||:..:::|.|              .
Human   429 EGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQ--------------L 479

  Fly   600 ENLSSDYEKMQLNCGKLQKRIDSMEEDKKAVELEIQRILKDKNITELNLRSEEDRSSRLREETIS 664
            |.|..:..:::....:||.:.||.:..|:..:.|:...::::...:..|...|.:.|....|.|:
Human   480 EVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELIT 544

  Fly   665 LREELNRVSLNRDLLEQQRIESDNLINLLEKQKSDLEYDLDKLLLEKCDLQEKHEKLSN-NSCST 728
            |||.|....|..:||.|::.|....:...|:..::|....:.|..|..||:....|||. |....
Human   545 LREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALA 609

  Fly   729 SDELKSVQNCLQEAQEERKKL--RIQSVDQCNEIGELKKELAILDKARLELETDNLSAGEKLKCL 791
            .|::...|..|| .:||.:.:  |:::.:|..  ..|:.:||..:|.|..|...|.....:|:..
Human   610 LDKVGLNQQLLQ-LEEENQSVCSRMEAAEQAR--NALQVDLAEAEKRREALWEKNTHLEAQLQKA 671

  Fly   792 QLEKEKILQDLACVTRDRGDIHNQLTAMCRKKEALNEELMRTRQRLEQTTETNSRLNRNLEEMVK 856
            :....::..||..:..::.:|..:|:....::||...:|.:..|..::..|..:|..:..|.:|:
Human   672 EEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVR 736

  Fly   857 DVEEKQVVIDLHEKDTHRLNELLAALRSEKESLESVLFDTNTSLEATEERRSQLERDLQEALVRE 921
            :....:|.:...|:|...|.|.|..|.|.||.|||.||:........|..:.|||..:|.....:
Human   737 EKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAK 801

  Fly   922 ESLKNHVARLQKELEQCQRKAQETKTQLLNAARAAESDFNQKIANLQACAEEAAKRHGEEILQLR 986
            |.::..|..|:.||:..:.:|::.:...  |.:.|:::...|.|     .|:....|.:|:.|||
Human   802 EVIQGEVRCLKLELDTERSQAEQERDAA--ARQLAQAEQEGKTA-----LEQQKAAHEKEVNQLR 859

  Fly   987 NALEK----RMQQALQALQTAKDDEIEKLQERLATLQAHLESLVQQHEEALIRAESEKQQALLIA 1047
            ...||    ..|:..:||::.:.:::| |:.||...|..:|::..|.||...:|||...|..|..
Human   860 EKWEKERSWHQQELAKALESLEREKME-LEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLET 923

  Fly  1048 HRDKQAVAERLEAVSRDLKTEQESLDRSRREANARDEKQRAAIAQLKDEMVQMRTKEEEHKIKLE 1112
            .:::.::.|.|....::|....:.|:|.|::...:..|::.....|       :|:.:|.:.:|:
Human   924 EKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGIL-------QTQLQEAQRELK 981

  Fly  1113 ECIRKQELQLSSLREERESLC-------RVSEELKMEIRLKEDRMESTNNELQDALRKSKEGEGF 1170
            |..|:....|::|:||..||.       :..|:||.::..::|.......|:|:.||:::|....
Human   982 EAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRI 1046

  Fly  1171 ---------------------------IDSLR-KELTDCRRQLADSNIERDKYSGSNKELRDHVK 1207
                                       .||:| :||:..|:.:.::..|:.:.|...:.||..||
Human  1047 QKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVK 1111

  Fly  1208 RVES-------------------------------AKREQ------------------------- 1216
            ..|:                               ||..|                         
Human  1112 EKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQA 1176

  Fly  1217 -------------------------------------------------------------ARAI 1220
                                                                         |.|:
Human  1177 QAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAV 1241

  Fly  1221 EEALQK------------------ISNLEDTKNSLENERTRLSTILKETENHFTKTTQ------- 1260
            ..||.|                  :..||:.....|.|::::.|.|::.:...::..:       
Human  1242 ASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEG 1306

  Fly  1261 ----------DLNATKAQLQK---------------------------AQVEFAQ---------- 1278
                      :|:.|.|.||.                           ||||..|          
Human  1307 KQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQA 1371

  Fly  1279 ----------------------------------KDEG------GKELQCKLVAEVELKERAQQE 1303
                                              :::|      ||.||..|....:.....::|
Human  1372 SAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEE 1436

  Fly  1304 LCQIKKQLSDLEANLCATRQELGRARCQ--------NNQE------------------EH---RF 1339
            :..::.|:.:||     .::|:.:|..:        .|||                  ||   ..
Human  1437 VETLRGQIQELE-----KQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAV 1496

  Fly  1340 HAREQELAQRLEEGRGREKRLEDQKHNLEVCLADATQQIQELKARLGGAEGRIRALDEQ---LSC 1401
            ..|||:|..:.|:.|..||..|.|::.||..|.:..::.|.::::    .|:::.|.:|   |.|
Human  1497 QEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQ----RGQVQDLKKQLVTLEC 1557

  Fly  1402 VEL------HKRDTEQKLSSVVHTLRRIAGIQVDGSVNLSHRLLSPSRRF----SPSRSCGDYDN 1456
            :.|      ||.:.:|||      ::.:.|.:....|.|:|..|....|.    :.|....|.::
Human  1558 LALELEENHHKMECQQKL------IKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLES 1616

  Fly  1457 RSTSQCPDGPIDVDPDLVR------KGVRNLMHQVAQLEREKDDY-------KSQLGAAKKQLQD 1508
            .||.            |.|      :.|::...|:.:|:|:|:..       ..:|...|:::|.
Human  1617 HSTV------------LARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQV 1669

  Fly  1509 AADQQLR----------------------------------------CDAKLGKLQAM------- 1526
            ..||:.|                                        ..|:.|.|:.|       
Human  1670 LEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDK 1734

  Fly  1527 ----------LRNLQEEKSNLE-----------------TDRKMKISAIQ-----------ALEE 1553
                      :..|||.|..||                 :.|:.:|..:|           ..|:
Human  1735 EKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ 1799

  Fly  1554 KLKHRNDECQMLRERLAQTEMQLAATSEE----NGQNEERLEKS--------------RQQCSKL 1600
            .|:.:.||.|   ..|||.:.:|.|..:|    .||.|...||:              :::..:|
Human  1800 SLQSQLDEAQ---RALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGEL 1861

  Fly  1601 DNEK---RQLQEELAKVEGR---------------------------------ASKLELQRVAME 1629
            .:.|   |:|:|||| ||||                                 |.:.|::..|::
Human  1862 QDHKEQARRLEEELA-VEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQ 1925

  Fly  1630 GDLTRLQMALQEKDCSI-----------------RQMAERLE------------NQNRALTQ--- 1662
            ....:.|..|:|:|..:                 |..||.|:            .:...|.|   
Human  1926 DSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAEL 1990

  Fly  1663 ---LEDRCTALKSTVD-------QLKE--RLQKSAVSETQLR--GEIKTLQKELSEQGHCSQANE 1713
               ||.....|::::|       ||:|  |:|:..:.:..||  .:::.||:.|:::....:..:
Human  1991 SRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQ 2055

  Fly  1714 DKLKLVQKS------------------------------------LQTAENEKRILTERLDSAQT 1742
            ::.:|::||                                    |..|:.|:.||..|....:.
Human  2056 EREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRN 2120

  Fly  1743 NLNELRRS--------QQAQLDG-NQRLQEQVTDLEVQRSALESQLRIAKWNQESGGDKD----L 1794
            ||..|..|        |..:||. ..|||.::..|  |.:..:::.|..:|.:::   :|    |
Human  2121 NLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERL--QAALRQTEAREIEWREKA---QDLALSL 2180

  Fly  1795 TNGNGGGNGEEELSRQLKSSQREKSELRSKLQTLQDKVKQLECDRKSKFSGGNAYDRAEKSNSFY 1859
            .......:..:|::..|::|..|:.   |:.|.|||   :||..|::          .||.....
Human  2181 AQTKASVSSLQEVAMFLQASVLERD---SEQQRLQD---ELELTRRA----------LEKERLHS 2229

  Fly  1860 GGAAESGEFDS-NRYDVGGGNAGGGSFN---CGLDHSVIEQETRDLRLKVRRLETLLAEKESELA 1920
            .||..:.|..| ....|..|...|....   .|::.....|....|:..|.|||...:..:....
Human  2230 PGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNV 2294

  Fly  1921 RCKARMNDSAKCHDGLDGDRYRSAQMHAEKLLDAREQSHRQQ------------VLRLENQISML 1973
            :.::.:....:....|..:..|:||..:.::..|...|..||            |..|:.::.:|
Human  2295 QLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLL 2359

  Fly  1974 REQLAQEAKRRQQYILRSSKANREMQHLRSTLGDSLRNVSQHPVDPHLLESESRRLDSAVSMSL 2037
            :.||..|.|::|.||.||::.:||:..|..:|..||..|:|.| :..:||:|:||||.:::.||
Human  2360 QAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAP-EATVLEAETRRLDESLTQSL 2422

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RootNP_001287497.1 Rootletin 110..332 CDD:291694 73/221 (33%)
Smc 555..1384 CDD:224117 220/1135 (19%)
SMC_prok_B 991..>1779 CDD:274008 237/1340 (18%)
CEP250NP_009117.2 Rootletin 40..215 CDD:291694 74/226 (33%)
Smc 252..1057 CDD:224117 189/837 (23%)
TIGR04376 <604..>709 CDD:275169 23/107 (21%)
SMC_prok_B 790..1552 CDD:274008 136/785 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1273..1308 4/34 (12%)
SMC_prok_B 1277..2019 CDD:274008 140/772 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1699..1725 2/25 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1820..1839 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2223..2244 6/20 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2307..2345 8/37 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2416..2442 2/7 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146338
Domainoid 1 1.000 120 1.000 Domainoid score I5759
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D48753at33208
OrthoFinder 1 1.000 - - FOG0001653
OrthoInspector 1 1.000 - - otm40904
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23159
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X3005
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
98.910

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