DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Root and cep250

DIOPT Version :9

Sequence 1:	NP_001287497.1	Gene:	Root / 42860	FlyBaseID:	FBgn0039152	Length:	2048	Species:	Drosophila melanogaster
Sequence 2:	XP_004915842.2	Gene:	cep250 / 100498015	XenbaseID:	XB-GENE-22068256	Length:	2986	Species:	Xenopus tropicalis

Alignment Length:	2403	Identity:	522/2403 - (21%)
Similarity:	914/2403 - (38%)	Gaps:	681/2403 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 RRRLDTYKQAQHNQANLVSRLQSKIQQYRQRCSDLEERMHETIKPTAGVGPKLTTGPTNQVLCST 174
            ::.|.....||..||.||.:||:|:.|||.|..:|::..                        ..
Frog    15 QKELQNSLDAQKRQAVLVEKLQAKVIQYRNRYQELQQSQ------------------------EW 55

  Fly   175 SLTLGQSSLPCSSSLDSPPPSCSRDYVDDVLVTGGGAGAAELCRKLEEEHQRCEQIVAQNSALRQ 239
            ||..|::.|                              ....:|||||.||||.:.|.|:.||:
Frog    56 SLDHGETEL------------------------------ERALQKLEEEQQRCENLAAVNALLRE 90

  Fly   240 QLEESNRTNEALTNDLQKLTNDWASLRDELLIKEDEFKEEEQAFKDYYNSEHNRLLKMWREVVAV 304
            .|..:...|:.|.||:.|||.||.|...||..||:::::|.:.:......||:|||::|.|||..
Frog    91 DLGHTQEANKVLCNDMHKLTADWTSALQELKHKENDWEQEREHYNSLMKGEHSRLLRIWTEVVTF 155

  Fly   305 KRSFKEMQTAMKAEVAKM----------------------------------------------- 322
            :|.|:|:::|.:.:::.:
Frog   156 RRHFRELKSATERDLSSVRADWSRCLCLIQSCCSSLKSYKIHGLPVLPSPEPPAYLLLTWDHGVG 220

  Fly   323 -GQEINCVGKDINGSNATVAFAVQQAKRAADDELKQSQRSNDELQNQLATLKVQYESARHEIMER 386
             |.:.....:....||.|.|....:..::.::..||...|:..|   |.|.....||.|.::...
Frog   221 SGDQDEAPAEQGMESNVTNATHDMELMKSLNESFKQEILSSRLL---LETSGQTLESMRSQLEIS 282

  Fly   387 DQRLLELMNQLKKLEDRCAQAESQAALASRYSDEIERLNNSMREIAQAVVQDAENADREADAEVT 451
            :..::.:.:.::.||.......||...|.|   ||..| .|.:|.:|..|... .:..|...|.:
Frog   283 ENNVILIQSHVEALEAEVISVRSQLETAQR---EITLL-RSQKETSQNEVFSI-RSKHETAKEES 342

  Fly   452 GGVMQHMHLTRDAASVVGGAGGAGSTAGGGGKSPRRNSTRASQAFAEGTISAVQAALHKYQLALH 516
            ..|...:..||:                         ..|:.::..| |...|:.:|......|
Frog   343 RSVHAQLETTRE-------------------------ELRSMRSQVE-TADEVERSLRSQVATL- 380

  Fly   517 DMQVKFQNTSETLRTTKAQLETSEGTKQLLTTKMQQLTEKLDSSNSKLSELLQERESLQRGL--- 578
                     .:.:|:|:.|||||:...|.:|::::...|:.....|:|.   .|.|:.|..|
Frog   381 ---------EQDIRSTRLQLETSKEDTQSMTSRLEAQKEEAAILRSQLE---AEEETSQLKLKAS 433

  Fly   579 -DDIRVQKQQSEMGRADINSAFENLSSDYEKMQLNCGKLQKRIDSME-------EDKKAVELEI- 634
             .:|:..:||.:|..|:::.....|:..    .|....|:.|:::.|       ||||. ||.|
Frog   434 EQEIKALRQQIQMSEAELSFVRSELAGS----TLEAESLKSRLETYEMEAKSRLEDKKQ-ELRIS 493

  Fly   635 QRILKDKNITELNLRSEEDRSSRLREETISLREELNRVSLNRDLLEQQ---------RIESDN-- 688
            ||:.:...:.|.      :||: ..:|.|..||:|.|..|..:|..::         .:|..|
Frog   494 QRMQQSLEVLEC------ERSA-AHQELIQCREDLLRSQLEGELCREECKGLRSALSEVERKNVE 551

  Fly   689 LINLLEKQKSDLEY---------DLDKLL-LEKCDLQEKHEKLSNNSCSTSDELKSVQNCLQEAQ 743
            |.....|.|:::::         ||::.| |:|.       :|:|.......|:.|::..|||::
Frog   552 LAMAQSKHKAEVDHLQDAVSKMGDLNRALSLDKV-------QLNNLILQMEREVASLRERLQESE 609

  Fly   744 EE-----------------RKKLRIQSVDQCNEIGELKKELAIL--DKARLELE-TDNLSAGEKL 788
            :|                 :::.:.|..:...|  .|:.|||.:  ::.||:.| |..:|..|:.
Frog   610 KELALAREQLHSELSAEIAKRQHQAQESEGAKE--SLEAELADVMGERERLQAELTQVISQLEEE 672

  Fly   789 KC--------LQLEKEKILQDLACVTRDRGDIHNQLTAMCRKKEALNEELMRTRQRLEQTTETNS 845
            ||        ||.|:..:...|..:.|:..|:..:|......|::|...|..::.|..|...:.|
Frog   673 KCRWCQDTETLQREQSTVTVQLEVMERECRDLREKLKNTESMKQSLESSLFASQDRASQLDISCS 737

  Fly   846 RLNRNLEEMV--KDVEEKQVVIDLHEKDTHRLNELLA--------------------ALRSEKES 888
            :|......:|  |:..:.:|.|...|::|...| |||                    ||.:.|..
Frog   738 QLKMEFLAVVQSKETIQDEVSILYTERETSERN-LLALSQRLSDTEQELQEERAQRLALENAKNE 801

  Fly   889 LESVLFDTNT--SLEATEERRSQLERD----LQEALVREESLKNHVARLQKELEQCQRKAQETK- 946
            ||.|..:.|.  |.....||:::.|||    ||.:|.:|:.:..:: |.|.|......|..||:
Frog   802 LEIVADNLNVERSQRQAAERQAERERDVQRTLQGSLGKEQEMAGNL-RQQLEAATASLKLLETEV 865

  Fly   947 TQLLNAARAAESDFNQKIANL--QACAEEAAKRHGEEILQLRNALEKRMQQALQALQ------TA 1003
            :.|.::.:.::::....:.||  |...::...|..|.:.|...:.::..:.||...|      ..
Frog   866 SDLTHSLQDSQTEKETALYNLEHQTLMKQELSREIEILKQANRSCQEEKESALAITQRNARTIEE 930

  Fly  1004 KDDEIEKLQERLATL----QAHLESLVQ-----QHEEALIRAESEKQQALLIAHRDKQAVAERLE 1059
            ||.:|.:|:|.:...    :..|.||.|     |..|..||:..|..|.   |.::.:|....||
Frog   931 KDKQIVELRETVQVCSEAKETALTSLAQLNLTVQEREREIRSLKENIQR---AQQENEAAGNALE 992

  Fly  1060 AVSRDLKTEQES-----------LDRSRREANARDEKQRAAIAQLKDEMVQMRTKEEEHKIKLEE 1113
            .. |.:.:|.:|           .::.|..|...:|..|..:::...|:.:|:..|:||:.|:|.
Frog   993 HY-RKVTSETDSQVATLTEQIRECEKDRETAMKAEESSRITLSEKGREISKMKEAEKEHQFKMEN 1056

  Fly  1114 CIRKQELQLSSLREERESLCRVSEELK------------------------MEIR-LKE------ 1147
            .:::.|.|...|||:...|..:.:.||                        .||| |||
Frog  1057 ALKEIESQTIILREKDTFLETLKQRLKECEEEKTSALNSVHNQILALEGRDQEIRHLKEAARERE 1121

  Fly  1148 ----------DRMESTNNE---LQDALRKSKEGE----GFIDSLRKELTDCRRQLADSNIERDKY 1195
                      ..:|..|.|   |::||:|.:|.:    ||:.|....|.:     .||.|:..|
Frog  1122 IALCTLDIQSQTIEDRNKEVATLKEALQKCQEEKEAALGFLGSQNIHLAE-----RDSEIQLQK- 1180

  Fly  1196 SGSNKELRDHVKRVESA---KREQARAIEEALQKISNLEDTKNSLENERTRLSTIL------KET 1251
                :.:|...|..|.|   :.:::.|:||...::::|::..|.|  :|.:.||:|      :|.
Frog  1181 ----ETIRSLQKEKEEALLIREKKSNALEEKEDQLTSLQEIMNEL--QRQKESTLLQHMLIVEER 1239

  Fly  1252 ENHFTKTTQDLNATKAQLQ------KAQVEFAQKDEGGKELQCKLVAEVE------LKERAQQEL 1304
            |.......:.:...|..::      ::|.|.:::.:....:|.:|:.|..      |:|..|:|.
Frog  1240 ERDIKILQESVQREKDMVKHISDQWESQRESSERQKESTLIQHRLIVEERERDIKILQESVQRER 1304

  Fly  1305 CQIKKQLSDLEANLCATRQELGRARCQNNQE----EHRFHAREQEL-AQRLEEGRGREKRL---- 1360
            ..: |.:||        :.|..|...:..:|    :||....|:|. .:.|:|...|||.|
Frog  1305 DMV-KHISD--------QWESQRESAERQKESTLIQHRLIVEERERDIKILQESVQREKDLVKHI 1360

  Fly  1361 --------EDQKHNLEVCLADATQQIQELKARLGGAEGRIRALD-----------EQLSCVE--- 1403
                    |..:...|..|.....:|.||...|...|.....|:           |||..:.
Frog  1361 SDQWESQRESAERQKETELKGLLDKISELSQALSKKEREAELLERQTKRDSDLLQEQLDSLTQHL 1425

  Fly  1404 -----LHKRDT---------EQKLSSVV----HTLRRIAGIQVDGSVNLSHRLLSPSRRFSP--- 1447
                 .||:::         |||:|.:.    |..:.|..:|        .||...|:..:.
Frog  1426 EEKEIAHKKNSELQRENMALEQKVSELTQAEEHREKDIKFLQ--------ERLKELSQTLTENEI 1482

  Fly  1448 -SRSCGDYDNRSTSQCPDGPIDVDPDLVRKGVRNL--MHQVAQLEREKDDYKSQLGAAKKQLQD- 1508
             :.....:..:.||.......::...|..:....|  :.|:..|:||.:..:..|...:|:.:|
Frog  1483 GTERIKQHAEKDTSALKVRVSELSAALTMRDTIELETLEQIKSLKREIESCEMALSDKEKRAEDE 1547

  Fly  1509 ----------------------------AADQQLRCDAKLGKLQAMLRNLQE--EKS-------- 1535
                                        ..::::...|..|:|:.:...|:|  |||
Frog  1548 RRQSEKEISSLRQRVTELSEAIMSKEIQQEEREIEVRALKGRLEELEHALEESAEKSRVERQMFH 1612

  Fly  1536 NLETDRKMKI------------SAIQ-------ALEEK-LKHRND--ECQMLRERLAQTEMQLAA 1578
            ||.||....:            :.||       ||:|| .:|.:|  |.:|||:|:.:....: .
Frog  1613 NLITDHSWALLGEVPEGSREGDTLIQRAELFGKALKEKERRHMDDHREKEMLRQRVNELSQDI-I 1676

  Fly  1579 TSEENGQNE----------------ERLEKSRQQCSKLDNEKRQLQEELAKVEGRASKLELQRVA 1627
            ..|.:.:.|                |:.|...::..:.:|||..|:.   |..|....||.:|:|
Frog  1677 NKERDAEEELKALRRKTVELRQTLIEKEEDKAEEQRRSENEKEALRH---KATGLLQALEEERMA 1738

  Fly  1628 ME----------GDLTRLQMALQEKDCSIRQMAERLENQNRALTQLEDRCTALKSTVDQLKERLQ 1682
            .|          .||.:|:.||.|||..:|:..::.|.|          ..||:..:.:|.|.|.
Frog  1739 AEVRQGELDHLRVDLNKLRQALAEKDSELREEGKQHEKQ----------ICALQQKILELSETLM 1793

  Fly  1683 KSAVSETQLRGEIKTLQKELSEQGHCSQANEDKLKLVQKSLQTAENEK----------------- 1730
            ...:.:.::.|::|.|:..|.   ..|||      |::|.::|.:.||
Frog  1794 TKNIHKEEMEGQVKALKGRLE---ITSQA------LLEKEIETEKQEKERQTLDKLISELSQAVI 1849

  Fly  1731 ---------RILTERLDSAQTNLNELRRSQQAQLDGNQ--RLQEQVTDLEV-------QRSALES 1777
                     :.|||||..|..     ..::|.::|.::  .|:.||.||.:       :...|:.
Frog  1850 EEVPEDSEGKDLTERLGKAVR-----ENTKQLEVDRSEIGTLRRQVKDLSLALLQKDREGETLQE 1909

  Fly  1778 QLRIAKWNQESGG----DKDLTNGNGGGNGEEE----------LSRQLKSSQREKSELRSKLQTL 1828
            ::...:..:|..|    ||:..........|:|          ||:.|...:||...|:.::..|
Frog  1910 EMAAVRRKREELGQALRDKEQEKCEADTQKEKENESLSKKVKDLSQALLEKEREADILQDEVTAL 1974

  Fly  1829 QDKVKQLECDRKSKFSGGNAYDRAEK------------------SNSFYGGAAESGEFDSNRYDV 1875
            :.|.::|:...:.|     ..|:.||                  |.:.   ..:..|.|:.:.:|
Frog  1975 RRKGEELKQTLRDK-----EQDKIEKEVQNEKEREALSLKVEHLSQAL---LEKEREADTLQEEV 2031

  Fly  1876 GGGNAGGGSFNCGL---DHSVIEQETRD------LRLKVRRLETLLAEKESELARCKARMND-SA 1930
            ......|......|   :...||:|.::      |..||..|...|.|||||:...|.:..| :.
Frog  2032 AALRRKGEELKQTLKNKEQEHIEKEVQNEKEKEALSQKVEHLSQALLEKESEVELTKGKREDLTI 2096

  Fly  1931 KCHDGLDGDRYRSAQMHAEKLLDAREQSHRQQVLRLENQISMLREQLAQEA--KRRQQYILRSSK 1993
            :..|      .|..|:..||.:...|:..|:::..|..:::.|.|.|..:.  :..:|..::|.|
Frog  2097 QIRD------LRQFQLENEKEIKEEERQSRKEIKALRLKVTELSETLINKTLQEEEKQLEVKSLK 2155

  Fly  1994 ANREMQHLRSTLGDSLRNVSQHPVDPHLLESESRRLD--------SAVSMSLPPSSCRDYDRD 2048
            ...||                  .:..|||.|..|::        |.:.:||........|:|
Frog  2156 GRLEM------------------FENALLEKEKERMEKEVLKNQISELFLSLDERIIEGEDKD 2200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Root	NP_001287497.1	Rootletin	110..332	CDD:291694	62/269 (23%)
		Smc	555..1384	CDD:224117	237/1032 (23%)
		SMC_prok_B	991..>1779	CDD:274008	225/1059 (21%)
cep250	XP_004915842.2	Rootletin	16..181	CDD:405685	61/218 (28%)
		PRK02224	<252..>671	CDD:179385	108/486 (22%)
		Smc	481..1226	CDD:224117	183/779 (23%)
		Smc	1183..2055	CDD:224117	185/926 (20%)
		Smc	1782..2543	CDD:224117	95/465 (20%)
		Smc	<2229..2891	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5144
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48753at33208
OrthoFinder	1	1.000	-	-		FOG0001653
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23159
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020