DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MITF and RTG3

DIOPT Version :9

Sequence 1:	NP_001341533.1	Gene:	MITF / 4286	HGNCID:	7105	Length:	526	Species:	Homo sapiens
Sequence 2:	NP_009447.1	Gene:	RTG3 / 852171	SGDID:	S000000199	Length:	486	Species:	Saccharomyces cerevisiae

Alignment Length:	523	Identity:	115/523 - (21%)
Similarity:	183/523 - (34%)	Gaps:	173/523 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    93 SQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQ--------------AQRQQVKQYL 143
            :::.|.|..:...|.:.|:|..|.|...  |..||.:|...              ||:.:...|:
Yeast     5 NESEAENQRLLDELMNQTKVLQETLDFS--LVTPTPHHNDDYKIHGSAYPGGETPAQQHEKLSYI 67

Human   144 STTLANKHANQVLSLPCPNQPG-----------------DHVMPPVPG---------SSAPNSPM 182
            :|..:|.:.|.:.|....|...                 |.:.....|         ||....|:
Yeast    68 NTHNSNDNNNLMGSQARSNSQTPTASTIYEEAESQSSYLDDMFRTSQGGRPVTQNSISSIGQGPL 132

Human   183 A---MLTLNSNCEKEGFYKFEEQNRAESECPGMNTHSRASCMQMDDVIDDI-ISLESSYNEEILG 243
            .   .:..:|..::......::|...::|.|........:...|.::.||: .||.||.|.:
Yeast   133 RSSYSMAYDSPVDRAMNTPLQQQEGLKAELPHDFLFQHGTDDTMYNLTDDLSSSLSSSINSD--- 194

Human   244 LMDPALQMANTLPVSGNLIDLYGNQGLPPPGLTISNSCPANLP---------------------- 286
            :|.|     ||...|.:    |..|.|.|..::.:.|.....|
Yeast   195 MMTP-----NTYSSSFS----YNPQSLGPASVSSTYSPKVRSPSSSFRAGSFLSSSFRHGSINTP 250

Human   287 -----NIKRELTACIFP----------TESEARALAKERQKKDNHNLIERRRRFNINDRIKELGT 336
                 :|...:|..|.|          |..|     |.|:|::.||.:|||||..|..:|||||.
Yeast   251 RTRHTSISSNMTENIGPGSVPKILGGLTSDE-----KLRRKREFHNAVERRRRELIKQKIKELGQ 310

Human   337 LIPKS--NDPDM----RWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQEL 395
            |:|.|  |..|:    :.|||.||..:|:|::.|    ....|::.|:||.      ||.:|:||
Yeast   311 LVPPSLLNYDDLGKQIKPNKGIILDRTVEYLQYL----AEILEIQARKKKA------LLAKIKEL 365

Human   396 EMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCTTTLDLTDGTITFNNN 460
            | :.::...:|.|.|.                         .|||          :.|.   ||:
Yeast   366 E-EKKSSVAALSPFTN-------------------------NHHA----------SSGQ---NNS 391

Human   461 LGTGTEANQAYSVPTKMGSKLEDILMDDTLSPVGVTD---PLLSSVSPGASKTSSRRSSMSMEET 522
            ..:........|||        :.||::..|...:.:   ||..||       .:...:.:||..
Yeast   392 ENSEERIIDIRSVP--------NALMNEQNSKAELHNWEPPLYDSV-------GNHNHAGTMESH 441

Human   523 EHT 525
            .||
Yeast   442 PHT 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MITF	NP_001341533.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54
		MITF_TFEB_C_3_N	56..194	CDD:318217	25/143 (17%)
		Transactivation	224..295		20/98 (20%)
		HLH	309..369	CDD:238036	28/65 (43%)
		Leucine-zipper. /evidence=ECO:0000305\|PubMed:24631970	374..395		6/20 (30%)
		DUF3371	397..516	CDD:314681	19/121 (16%)
		DNA binding regulation	401..431		3/29 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..526		8/33 (24%)
RTG3	NP_009447.1	bHLHzip_USF_MITF	289..349	CDD:381393	26/63 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I3421
eggNOG	1	0.900	-	-		E1_KOG1318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000691
OrthoInspector	1	1.000	-	-		oto145058
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45776
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.940