DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MITF and Usf

DIOPT Version :9

Sequence 1:NP_001341533.1 Gene:MITF / 4286 HGNCID:7105 Length:526 Species:Homo sapiens
Sequence 2:NP_572167.3 Gene:Usf / 31384 FlyBaseID:FBgn0029711 Length:437 Species:Drosophila melanogaster


Alignment Length:389 Identity:76/389 - (19%)
Similarity:131/389 - (33%) Gaps:105/389 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    93 SQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYHIQQAQRQQVKQYLSTT---LANKHANQ 154
            :.|...:|::....|:|....|.:....|...:....|...|..||.....|.|   |.|....|
  Fly    22 TSTSPSSVNISNANPTAGPGLMTITNHHTADLSEALVHSSFANGQQSLILTSDTGNPLMNSQGAQ 86

Human   155 VLSLPCPNQPGD-----HVMPPVPGS------------SAPNSPMAMLTLNSNCEKEGFYKFEEQ 202
            :....|.::..|     :.:...||.            ..||:    |.|.:.||   .|..:|.
  Fly    87 IFLTICGDENSDDSQEYYTIKQEPGCDLDIHSLLPSNLQLPNN----LQLPTGCE---IYLVKET 144

Human   203 NRAESECPGMNTHSRASC-MQMDDVID----DIISLESSYNEEILGLMDPALQMANTLPVSGNLI 262
            .....|.|     ::|:. :::|.:.:    ..::..||....::     ..|..|. |:.||:.
  Fly   145 GSLMGEPP-----TKAAIKLELDTLSEKPLLPSVTTSSSTQSAVI-----TAQTVNP-PIPGNIN 198

Human   263 D-------------LYGNQGLPPPGLTISNSCPANLPNIKRELTACIFPTESEARALAKER--QK 312
            .             |||:.| ...|...:::...:.|....:       |.|......|:|  ::
  Fly   199 TTTSTTSTTTTTSVLYGSHG-NGHGHGHAHAQARSQPESAGQ-------TPSSKLEAYKKRDDKR 255

Human   313 KDNHNLIERRRRFNINDRIKELGTLIPK----------SNDPDMRW------------------- 348
            :..||.:|||||..||..|.:|..::|.          |..|....                   
  Fly   256 RATHNEVERRRRDKINSWIFKLKEMLPSLSSSSSFSEASTSPSTSGSTSTNGSSHSKGNASSSSG 320

Human   349 ------NKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLLRIQEL----EMQARAH 402
                  :|..||..:.:||:.:|.|....::.......|..:|:.|...:..|    ::|.|.|
  Fly   321 RAPPNDSKSQILIKACEYIKSMQGEIDTLRDCLRETDSLRASNQALREELDRLKRQQQLQERFH 384

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MITFNP_001341533.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..54
MITF_TFEB_C_3_N 56..194 CDD:318217 25/120 (21%)
Transactivation 224..295 14/87 (16%)
HLH 309..369 CDD:238036 22/96 (23%)
Leucine-zipper. /evidence=ECO:0000305|PubMed:24631970 374..395 3/20 (15%)
DUF3371 397..516 CDD:314681 3/6 (50%)
DNA binding regulation 401..431 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..526
UsfNP_572167.3 HLH 255..343 CDD:278439 19/87 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1318
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1708
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

Return to query results.
Submit another query.