Protein Alignment MITF and hlh-30

DIOPT Version :10

• Sequence 1: NP_001341533.1
• Gene: MITF / 4286
• HGNCID: 7105
• Length: 526
• Species: Homo sapiens
• Sequence 2: NP_001023411.1
• Gene: hlh-30 / 177157
• WormBaseID: WBGene00020930
• Length: 524
• Species: Caenorhabditis elegans
• Alignment Length: 570
• Identity: 146/570 - (25%)
• Similarity: 226/570 - (39%)
• Gaps: 187/570 - (32%)

Human    40 HPGASKPPISSSSMTSRILLRQQLMREQMQEQERREQQQKLQAAQF-------MQQR------VP 91
            :|.|.:||.:          :||...:|.|:|...::..:..|:||       |:||      :|
 Worm    18 NPRAQQPPGA----------QQQQQPQQAQQQFYDDEPYQANASQFRFGAGKSMEQRRETGNLIP 72

Human    92 VSQTPAINVSVPTTLPSATQVPMEVLKVQTH---------LENPTKYHIQQAQRQQVKQYLSTTL 147
            ::|...          .:|..|......|::         |.:|.|       .||..|.|...:
 Worm    73 IAQRSM----------GSTSTPFGSAPTQSYFGGGSSGAALSSPRK-------MQQTHQMLFGNI 120

Human   148 ANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEGFYKFEEQNRAESECPG- 211
                           || ....||..||                  :..::|     .||..||
 Worm   121 ---------------QP-PRGSPPSDGS------------------DKIHRF-----GESPTPGG 146

Human   212 ----MNTHSRASCMQMDD-VIDDIISLESSYNEEILGLMDP------------ALQMANTLPVSG 259
                ..|       ::|| :||:::.:|....      |.|            .:.||..:|.:.
 Worm   147 VGGVFGT-------ELDDLIIDELMGMEDDQR------MRPGATRPMTIGGEKTMSMARPIPGAS 198

Human   260 NLIDLYGNQGLPPPGLTISNSCPANLPNIKRELTACIFPTES---------------------EA 303
            :... .|:.|.|   :||.|:...|.    |::.:...||.|                     :.
 Worm   199 SRAG-SGHSGSP---ITIPNAMSNNF----RQVVSSSAPTSSIDIEKMIGAVSNGGGNSGGDNDP 255

Human   304 RALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQ 368
            ....::|:|||.||:||||||:||||||||||.::||:...||:.|||||||||.||||.||:::
 Worm   256 EDYYRDRRKKDIHNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQKDR 320

Human   369 QRAKELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQE----PVLE 429
            ::|.:.:.:||.||........|::|||......|:.:.||.....|.::.|.||||    |...
 Worm   321 EQAMKTQQQQKSLESTAHKYADRVKELEEMLARQGVQVPPSHLPPIPKVIERPIKQEIDESPPNH 385

Human   430 NCSQDLLQHHADLTCTTTLDLTDGTITF----------NNNLGTGTEANQAYSV--------PTK 476
            ..:...:.....|:     ::|:.|...          ||.:.....::..:||        .|.
 Worm   386 TPTGSFVSSSGFLS-----EVTNNTAAMQITSPNDSRPNNFMNNSAPSDSFFSVGSASPPDYRTS 445

Human   477 MGS---KL------EDILMDDTLSPVGVTDPLLSSVS--PGASKTSSRRS 515
            .|:   ||      .|::||| |:|:...|||:||..  |.....||:.|
 Worm   446 SGTASWKLPGSNAFSDLMMDD-LNPMMNGDPLISSAGAHPSPHFHSSQMS 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MITF	NP_001341533.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54		4/13 (31%)
		MITF_TFEB_C_3_N	56..194	CDD:464952	29/159 (18%)
		Transactivation	224..295		18/83 (22%)
		bHLHzip_MITF	300..403	CDD:381496	51/123 (41%)
		Leucine-zipper. /evidence=ECO:0000305|PubMed:24631970	374..395		5/20 (25%)
		DUF3371	397..516	CDD:463372	36/152 (24%)
		DNA-binding regulation	401..431		10/33 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..526		9/22 (41%)
hlh-30	NP_001023411.1	bHLHzip_MITF_like	260..328	CDD:381403	42/67 (63%)