Protein Alignment MITF and Mitf

DIOPT Version :10

• Sequence 1: NP_001341533.1
• Gene: MITF / 4286
• HGNCID: 7105
• Length: 526
• Species: Homo sapiens
• Sequence 2: NP_001106669.1
• Gene: Mitf / 17342
• MGIID: 104554
• Length: 526
• Species: Mus musculus
• Alignment Length: 526
• Identity: 497/526 - (94%)
• Similarity: 508/526 - (96%)
• Gaps: 0/526 - (0%)

Human     1 MQSESGIVPDFEVGEEFHEEPKTYYELKSQPLKSSSSAEHPGASKPPISSSSMTSRILLRQQLMR 65
            ||||||||.|||||||||||||||||||||||||||||||.||||||:|||:|||||||||||||
Mouse     1 MQSESGIVADFEVGEEFHEEPKTYYELKSQPLKSSSSAEHSGASKPPLSSSTMTSRILLRQQLMR 65

Human    66 EQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYH 130
            |||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||
Mouse    66 EQMQEQERREQQQKLQAAQFMQQRVAVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYH 130

Human   131 IQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEG 195
            ||||||.|||||||||||||||:||||.|||||||||.||||||||||||||||||||||||||.
Mouse   131 IQQAQRHQVKQYLSTTLANKHASQVLSSPCPNQPGDHAMPPVPGSSAPNSPMAMLTLNSNCEKEA 195

Human   196 FYKFEEQNRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGN 260
            |||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 FYKFEEQSRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGN 260

Human   261 LIDLYGNQGLPPPGLTISNSCPANLPNIKRELTACIFPTESEARALAKERQKKDNHNLIERRRRF 325
            |||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 LIDLYSNQGLPPPGLTISNSCPANLPNIKRELTACIFPTESEARALAKERQKKDNHNLIERRRRF 325

Human   326 NINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLL 390
            |||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||
Mouse   326 NINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKDLENRQKKLEHANRHLLL 390

Human   391 RIQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCTTTLDLTDGTI 455
            |:|||||||||||||||||||||||||||||||||||||||||:|:||.||||||||||||||||
Mouse   391 RVQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQELVQHQADLTCTTTLDLTDGTI 455

Human   456 TFNNNLGTGTEANQAYSVPTKMGSKLEDILMDDTLSPVGVTDPLLSSVSPGASKTSSRRSSMSME 520
            ||.|||||..|::.|||:|.||||.||||||||.|||||||||||||||||||||||||||||.|
Mouse   456 TFTNNLGTMPESSPAYSIPRKMGSNLEDILMDDALSPVGVTDPLLSSVSPGASKTSSRRSSMSAE 520

Human   521 ETEHTC 526
            ||||.|
Mouse   521 ETEHAC 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MITF	NP_001341533.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54		48/52 (92%)
		MITF_TFEB_C_3_N	56..194	CDD:464952	132/137 (96%)
		Transactivation	224..295		69/70 (99%)
		bHLHzip_MITF	300..403	CDD:381496	100/102 (98%)
		Leucine-zipper. /evidence=ECO:0000305|PubMed:24631970	374..395		19/20 (95%)
		DUF3371	397..516	CDD:463372	105/118 (89%)
		DNA-binding regulation	401..431		29/29 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..526		28/29 (97%)
Mitf	NP_001106669.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..54		30/33 (91%)
		MITF_TFEB_C_3_N	56..194	CDD:464952	132/137 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	155..179		21/23 (91%)
		Transactivation. /evidence=ECO:0000250	224..291		65/66 (98%)
		bHLHzip_MITF	300..403	CDD:381496	100/102 (98%)
		Leucine-zipper. /evidence=ECO:0000305|PubMed:23207919	374..395		19/20 (95%)
		DUF3371	397..522	CDD:463372	110/124 (89%)
		DNA-binding regulation. /evidence=ECO:0000250	401..431		29/29 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..526		28/29 (97%)