Protein Alignment MITF and mitfb

DIOPT Version :10

• Sequence 1: NP_001341533.1
• Gene: MITF / 4286
• HGNCID: 7105
• Length: 526
• Species: Homo sapiens
• Sequence 2: NP_571922.2
• Gene: mitfb / 114833
• ZFINID: ZDB-GENE-010919-1
• Length: 500
• Species: Danio rerio
• Alignment Length: 560
• Identity: 335/560 - (59%)
• Similarity: 402/560 - (71%)
• Gaps: 94/560 - (16%)

Human     1 MQSESGIVPDFEVGEEFHEEPKTYYELKSQPLKSSSSAEHP-GASKPPISSSSMTSRILLRQQLM 64
            ||||||||||||||::||||||||||||||||::|:.:|.. |:.|||:.|    ||:|||||||
Zfish     1 MQSESGIVPDFEVGDDFHEEPKTYYELKSQPLQNSNPSEQQHGSCKPPLGS----SRVLLRQQLM 61

Human    65 REQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKY 129
            |||:|:|||||||::         ::.::.:||||||.|...|||.|||||||||||||||||||
Zfish    62 REQLQQQERREQQKR---------QISITHSPAINVSHPCGPPSAAQVPMEVLKVQTHLENPTKY 117

Human   130 HIQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDH-VMPPVPGSSAPNSPMAMLTLNSNCEK 193
            |||||||||||.||||||..|   |.:|||||:|..|| .|||.||:||||||||:||||.||||
Zfish   118 HIQQAQRQQVKAYLSTTLGGK---QAVSLPCPSQASDHGGMPPGPGNSAPNSPMALLTLNPNCEK 179

Human   194 EGFYKFEEQNRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGL-MDPALQMANTLPV 257
            |                            |||||||||.|||||:::|:|| :||.||||||:||
Zfish   180 E----------------------------MDDVIDDIIGLESSYSDDIMGLSLDPGLQMANTIPV 216

Human   258 SGNLIDLYGNQGLPPPGLTISNSCPANLPNIKREL---------------TACI----------F 297
            |.||:|:|.|.||||||::||||||||:.::|||.               ::|.          |
Zfish   217 SANLLDMYSNPGLPPPGISISNSCPANMTSVKREFSVTPSPALMHMMDKPSSCSKFESYQRPEGF 281

Human   298 PTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIR 362
            |.|.|.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   282 PVEVEVRALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIR 346

Human   363 KLQREQQRAKELENRQKKLEHANRHLLLRIQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPV 427
            ||||||.|.||||||||||||.||:|||||||||:|||||||:: .|:.||:.:|..|.|||||:
Zfish   347 KLQREQHRTKELENRQKKLEHTNRNLLLRIQELEIQARAHGLAM-ASSALCASELAARAIKQEPL 410

Human   428 LENCSQDL---LQHH---ADLTCTTTLDLTDGTITFNNNLGTGTEANQAYSVPTKMGSKLEDILM 486
            |.:||||:   ...|   ||::.::||||.:|||:|::...:.|.|           :||:||||
Zfish   411 LGDCSQDMYTSTHAHPSCADMSRSSTLDLNNGTISFSDTHLSDTHA-----------AKLDDILM 464

Human   487 DDTLSPVGVTDPLLSSVSPGASKTSSRRSSMSMEETEHTC 526
            |:||:.....:.|:|:    ||..|:.:.||:|||.:|.|
Zfish   465 DETLTSGATNESLISA----ASNESTHKDSMNMEENQHAC 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MITF	NP_001341533.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54		37/53 (70%)
		MITF_TFEB_C_3_N	56..194	CDD:464952	95/138 (69%)
		Transactivation	224..295		49/86 (57%)
		bHLHzip_MITF	300..403	CDD:381496	95/102 (93%)
		Leucine-zipper. /evidence=ECO:0000305|PubMed:24631970	374..395		18/20 (90%)
		DUF3371	397..516	CDD:463372	49/124 (40%)
		DNA-binding regulation	401..431		15/29 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..526		11/29 (38%)
mitfb	NP_571922.2	MITF_TFEB_C_3_N	53..186	CDD:464952	101/172 (59%)
		bHLHzip_MITF	284..387	CDD:381496	95/102 (93%)
		DUF3371	381..496	CDD:463372	53/130 (41%)