Protein Alignment MITF and mitf

DIOPT Version :10

• Sequence 1: NP_001341533.1
• Gene: MITF / 4286
• HGNCID: 7105
• Length: 526
• Species: Homo sapiens
• Sequence 2: NP_001093747.1
• Gene: mitf / 100101790
• XenbaseID: XB-GENE-484962
• Length: 483
• Species: Xenopus tropicalis
• Alignment Length: 524
• Identity: 406/524 - (77%)
• Similarity: 453/524 - (86%)
• Gaps: 42/524 - (8%)

Human     1 MQSESGIVPDFEVGEEFHEEPKTYYELKSQPLKSSSSAEHPGASKPPISSSSMTSRILLRQQLMR 65
            |||||||||||:|||||||||||||||||||||.|||||||||||||:|||||||||||||||||
 Frog     1 MQSESGIVPDFDVGEEFHEEPKTYYELKSQPLKYSSSAEHPGASKPPLSSSSMTSRILLRQQLMR 65

Human    66 EQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYH 130
            ||||:|||||||||.|||||||||..||.|||||||  ::||::.||||||||||||||||||||
 Frog    66 EQMQQQERREQQQKQQAAQFMQQRAAVSHTPAINVS--SSLPASPQVPMEVLKVQTHLENPTKYH 128

Human   131 IQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEG 195
            |||||:|||||||:|.   ||:.|.||||||||||||:|||.|||||||||||:||:.|.||||
 Frog   129 IQQAQKQQVKQYLTTA---KHSGQALSLPCPNQPGDHIMPPGPGSSAPNSPMALLTIGSTCEKE- 189

Human   196 FYKFEEQNRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGN 260
                                       |||||||||||||||||:|| ||||::|||||||||||
 Frog   190 ---------------------------MDDVIDDIISLESSYNEDIL-LMDPSMQMANTLPVSGN 226

Human   261 LIDLYGNQGLPPPGLTISNSCPANLPNIKRELTACIFPTESEARALAKERQKKDNHNLIERRRRF 325
            :||:|||||:|||||.:|||||||||:||||.      |||||||||||||||||||||||||||
 Frog   227 MIDIYGNQGMPPPGLNVSNSCPANLPHIKREF------TESEARALAKERQKKDNHNLIERRRRF 285

Human   326 NINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLL 390
            |||||||||||||||||||||||||||||||||||||||||||||:||:||:|||||||||||||
 Frog   286 NINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRSKEVENKQKKLEHANRHLLL 350

Human   391 RIQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCTTTLDLTDGTI 455
            |||||||||||||||::|||||||.|||||:|||||:|::|:|::|.:|.||:.|||||||||||
 Frog   351 RIQELEMQARAHGLSIMPSTGLCSTDLVNRVIKQEPMLDSCNQEILSNHHDLSGTTTLDLTDGTI 415

Human   456 TFNNNLGTGTEANQAYSVPTKMGSKLEDILMDDTLSPVGVTDPLLSSVSPGASKTSSRRSSMSME 520
            ||:|||...|::..|||:|||:||||||:.||||||| .|.|| ..::|||||:|:|||||:|||
 Frog   416 TFSNNLRNMTDSPTAYSIPTKLGSKLEDMFMDDTLSP-RVNDP-HHTISPGASRTNSRRSSISME 478

Human   521 ETEH 524
            |.:|
 Frog   479 ENDH 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MITF	NP_001341533.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54		49/52 (94%)
		MITF_TFEB_C_3_N	56..194	CDD:464952	110/137 (80%)
		Transactivation	224..295		58/70 (83%)
		bHLHzip_MITF	300..403	CDD:381496	99/102 (97%)
		Leucine-zipper. /evidence=ECO:0000305|PubMed:24631970	374..395		18/20 (90%)
		DUF3371	397..516	CDD:463372	81/118 (69%)
		DNA-binding regulation	401..431		23/29 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..526		18/29 (62%)
mitf	NP_001093747.1	MITF_TFEB_C_3_N	56..195	CDD:464952	116/171 (68%)
		bHLHzip_MITF	260..363	CDD:381496	99/102 (97%)
		DUF3371	357..480	CDD:463372	86/124 (69%)