DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MITF and mitf

DIOPT Version :9

Sequence 1:	NP_001341533.1	Gene:	MITF / 4286	HGNCID:	7105	Length:	526	Species:	Homo sapiens
Sequence 2:	NP_001093747.1	Gene:	mitf / 100101790	XenbaseID:	XB-GENE-484962	Length:	483	Species:	Xenopus tropicalis

Alignment Length:	524	Identity:	406/524 - (77%)
Similarity:	453/524 - (86%)	Gaps:	42/524 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     1 MQSESGIVPDFEVGEEFHEEPKTYYELKSQPLKSSSSAEHPGASKPPISSSSMTSRILLRQQLMR 65
            |||||||||||:|||||||||||||||||||||.|||||||||||||:|||||||||||||||||
Frog     1 MQSESGIVPDFDVGEEFHEEPKTYYELKSQPLKYSSSAEHPGASKPPLSSSSMTSRILLRQQLMR 65

Human    66 EQMQEQERREQQQKLQAAQFMQQRVPVSQTPAINVSVPTTLPSATQVPMEVLKVQTHLENPTKYH 130
            ||||:|||||||||.|||||||||..||.|||||||  ::||::.||||||||||||||||||||
Frog    66 EQMQQQERREQQQKQQAAQFMQQRAAVSHTPAINVS--SSLPASPQVPMEVLKVQTHLENPTKYH 128

Human   131 IQQAQRQQVKQYLSTTLANKHANQVLSLPCPNQPGDHVMPPVPGSSAPNSPMAMLTLNSNCEKEG 195
            |||||:|||||||:|.   ||:.|.||||||||||||:|||.|||||||||||:||:.|.||||
Frog   129 IQQAQKQQVKQYLTTA---KHSGQALSLPCPNQPGDHIMPPGPGSSAPNSPMALLTIGSTCEKE- 189

Human   196 FYKFEEQNRAESECPGMNTHSRASCMQMDDVIDDIISLESSYNEEILGLMDPALQMANTLPVSGN 260
                                       |||||||||||||||||:|| ||||::|||||||||||
Frog   190 ---------------------------MDDVIDDIISLESSYNEDIL-LMDPSMQMANTLPVSGN 226

Human   261 LIDLYGNQGLPPPGLTISNSCPANLPNIKRELTACIFPTESEARALAKERQKKDNHNLIERRRRF 325
            :||:|||||:|||||.:|||||||||:||||.      |||||||||||||||||||||||||||
Frog   227 MIDIYGNQGMPPPGLNVSNSCPANLPHIKREF------TESEARALAKERQKKDNHNLIERRRRF 285

Human   326 NINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLLL 390
            |||||||||||||||||||||||||||||||||||||||||||||:||:||:|||||||||||||
Frog   286 NINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRSKEVENKQKKLEHANRHLLL 350

Human   391 RIQELEMQARAHGLSLIPSTGLCSPDLVNRIIKQEPVLENCSQDLLQHHADLTCTTTLDLTDGTI 455
            |||||||||||||||::|||||||.|||||:|||||:|::|:|::|.:|.||:.|||||||||||
Frog   351 RIQELEMQARAHGLSIMPSTGLCSTDLVNRVIKQEPMLDSCNQEILSNHHDLSGTTTLDLTDGTI 415

Human   456 TFNNNLGTGTEANQAYSVPTKMGSKLEDILMDDTLSPVGVTDPLLSSVSPGASKTSSRRSSMSME 520
            ||:|||...|::..|||:|||:||||||:.||||||| .|.|| ..::|||||:|:|||||:|||
Frog   416 TFSNNLRNMTDSPTAYSIPTKLGSKLEDMFMDDTLSP-RVNDP-HHTISPGASRTNSRRSSISME 478

Human   521 ETEH 524
            |.:|
Frog   479 ENDH 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MITF	NP_001341533.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54		49/52 (94%)
		MITF_TFEB_C_3_N	56..194	CDD:318217	110/137 (80%)
		Transactivation	224..295		58/70 (83%)
		HLH	309..369	CDD:238036	59/59 (100%)
		Leucine-zipper. /evidence=ECO:0000305\|PubMed:24631970	374..395		18/20 (90%)
		DUF3371	397..516	CDD:314681	81/118 (69%)
		DNA binding regulation	401..431		23/29 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..526		18/29 (62%)
mitf	NP_001093747.1	MITF_TFEB_C_3_N	56..194	CDD:318217	115/170 (68%)
		HLH	269..329	CDD:238036	59/59 (100%)
		DUF3371	357..480	CDD:314681	86/124 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	223	1.000	Domainoid score	I13514
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4892
Inparanoid	1	1.050	779	1.000	Inparanoid score	I4630
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50034
OrthoDB	1	1.010	-	-		D1211990at2759
OrthoFinder	1	1.000	-	-		FOG0000691
OrthoInspector	1	1.000	-	-		oto151911
Panther	1	1.100	-	-	LDO	PTHR45776
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X566
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.080