DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13605 and SYVN1

DIOPT Version :9

Sequence 1:	NP_651214.2	Gene:	CG13605 / 42858	FlyBaseID:	FBgn0039150	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_757385.1	Gene:	SYVN1 / 84447	HGNCID:	20738	Length:	617	Species:	Homo sapiens

Alignment Length:	328	Identity:	69/328 - (21%)
Similarity:	120/328 - (36%)	Gaps:	123/328 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 HLISDDMV--------VQILSHFVRYLPLIFILFFKFLHDHLLGIVDLLVLQTVMYNVNRSVRNQ 392
            |.:::|.|        :..|.| .|.:.|:|          ||||:|.|.:....:::
Human   117 HWLAEDRVDFMERSPNISWLFH-CRIVSLMF----------LLGILDFLFVSHAYHSI------- 163

  Fly   393 VARLAQKNYAVMVRDTFLVAVVVTVRLFLATSPPDPFGLIVPPSRKSVFIEVTALPFHTSSEGDS 457
                ..:..:|.:...|..|:::|:.|                   ::||:.........||  :
Human   164 ----LTRGASVQLVFGFEYAILMTMVL-------------------TIFIKYVLHSVDLQSE--N 203

  Fly   458 PTTSSEPIKTNMYKDTYKSLNVIPLGMLLYYIAVSDLIIKLLTMLVKLIITMLPHHLMRLKVRAR 522
            |..:.                           ||..|..:|.|..:|:::.|.   .|.:.::..
Human   204 PWDNK---------------------------AVYMLYTELFTGFIKVLLYMA---FMTIMIKVH 238

  Fly   523 LYVLVEYISQFYRAMTPITQWLLFLYESYSGLEVVSGGLFSAMYLGAKIFELVERGKSLKKAIVT 587
            .:.|.        |:.|                         |||..:.|:     |::..||::
Human   239 TFPLF--------AIRP-------------------------MYLAMRQFK-----KAVTDAIMS 265

  Fly   588 FR--KNIDSERP-PTKDELDAAGALCPICHDAFNTPTV-LECGHIFCDECVQTWFKREQTCPMCR 648
            .|  :|:::..| .|.:||.|...:|.||.:...|... |.|.|||...|:::||:|:||||.||
Human   266 RRAIRNMNTLYPDATPEELQAMDNVCIICREEMVTGAKRLPCNHIFHTSCLRSWFQRQQTCPTCR 330

  Fly   649 AKV 651
            ..|
Human   331 MDV 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13605	NP_651214.2	RING	610..651	CDD:238093	19/41 (46%)
SYVN1	NP_757385.1	Involved in FAM8A1 interaction. /evidence=ECO:0000269\|PubMed:28827405	1..251		37/239 (15%)
		Necessary and sufficient for SEL1L interaction. /evidence=ECO:0000269\|PubMed:28827405	1..84
		HRD1	10..>333	CDD:227568	68/326 (21%)
		Interaction with p53/TP53. /evidence=ECO:0000269\|PubMed:17170702	236..270		11/71 (15%)
		zf-RING_2	289..330	CDD:290367	17/40 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..375
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..453
		HAF-H domain, necessary to form higher-order Hrd1 complexes. /evidence=ECO:0000303\|PubMed:28827405	480..535
		Nha1_C	<528..611	CDD:285783
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	535..617
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D897451at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820