DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13605 and Rnft1

DIOPT Version :9

Sequence 1:	NP_651214.2	Gene:	CG13605 / 42858	FlyBaseID:	FBgn0039150	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_084064.1	Gene:	Rnft1 / 76892	MGIID:	1924142	Length:	395	Species:	Mus musculus

Alignment Length:	443	Identity:	113/443 - (25%)
Similarity:	175/443 - (39%)	Gaps:	120/443 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 HNHSLNGGRHNASA-IGLNSNPAAFDER----------------------------EANESQDLD 309
            |:.|..|..|.... |.:||.|..:.|.                            ||....|..
Mouse    26 HSRSTEGSLHPGDVHIQINSGPKEYSENPSSRNPRSGVCTCAHGCVHGRFRSYSHSEARPPDDFA 90

  Fly   310 ESDGNVENGGGGGNPPEPAENNPEDEHLISDDMVVQILSHFVRY--------LPLIFILFFKFLH 366
            ...|  |:|.|.                         .|.| ||        ||.|.||..|.:.
Mouse    91 TESG--EHGSGS-------------------------FSEF-RYLFKWLQKSLPYILILGIKLVM 127

  Fly   367 DHLLGI-VDLLVLQTVMYNVNRSVRNQVARLAQKNYAVMVRDTFLVAVVVTVRLFLATSPPDPFG 430
            .|:.|| :.:.:|.|.|| .|:|:.|||   ..:..:..:|..:|:       :|||.|
Mouse   128 QHITGISLGIGLLTTFMY-ANKSIVNQV---FLRERSSKLRCAWLL-------VFLAGS------ 175

  Fly   431 LIVPPSRKSVFIEVTALPFHTSSEGDS-----PTTSSEPIKTNMYKDTYKSLNVIPLGMLLYYIA 490
                    ||.:..|   ||:.|...|     ||                 |..:....:|:.:.
Mouse   176 --------SVLLYYT---FHSQSLHYSLIFLNPT-----------------LEQLSFWEVLWIVG 212

  Fly   491 VSDLIIKLLTMLVKLIITMLPHHLMRLKVRARLYVLVEYISQFYRAMTPITQWLLFL--YESYSG 553
            ::|.|:|...|.:|.:|.::|..:|..|.:...|:|:|.:.|:||...||..|..:|  |..:..
Mouse   213 ITDFILKFFFMGLKCLILLVPSFIMPFKSKGYWYMLLEELCQYYRIFVPIPVWFRYLISYGEFGN 277

  Fly   554 LEVVS-GGLFSAMYLGAKIFELVERGKSLKKAIVTFRKNIDSERPPTKDELDAAGALCPICHDAF 617
            :...| |.|.:.:||..|:.:.....::.::.:..|........|.:|.:......:|.||...|
Mouse   278 VTTWSLGILLALLYLILKLLDFFGHLRTFRQVLRVFFTRPSYGVPASKRQCSDMDGICTICQAEF 342

  Fly   618 NTPTVLECGHIFCDECVQTWFKREQTCPMCRAKVSD-DPAWQDGSTTFFHQLY 669
            ..|.:|.|.||||:||:..||.||:|||:||..:|: ...|:||:|:...|:|
Mouse   343 QKPVLLFCQHIFCEECITLWFNREKTCPLCRTVISECINKWKDGATSSHLQMY 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13605	NP_651214.2	RING	610..651	CDD:238093	22/40 (55%)
Rnft1	NP_084064.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		9/31 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..97		5/20 (25%)
		Required for ubiquitin ligase activity and for protection against ER stress-induced cell death. /evidence=ECO:0000250\|UniProtKB:Q5M7Z0	328..379		23/50 (46%)
		RING	335..376	CDD:238093	22/40 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847831
Domainoid	1	1.000	64	1.000	Domainoid score	I10092
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003057
OrthoInspector	1	1.000	-	-		otm42792
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15860
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4029
SonicParanoid	1	1.000	-	-		X1778
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830