DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13605 and Rnf145

DIOPT Version :9

Sequence 1:	NP_651214.2	Gene:	CG13605 / 42858	FlyBaseID:	FBgn0039150	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001350095.1	Gene:	Rnf145 / 74315	MGIID:	1921565	Length:	663	Species:	Mus musculus

Alignment Length:	351	Identity:	70/351 - (19%)
Similarity:	126/351 - (35%)	Gaps:	99/351 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   354 LPLIFILFFKFLHDHLLGIVDLLVLQTVMYN-------VNRSVRNQVARLAQKNYAVMVRDTFLV 411
            |.|:|.:.|.     .||::.|.......|.       :||.:...|..|      ::...|.|:
Mouse   278 LGLVFTVSFV-----ALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLL------ILAVQTGLI 331

  Fly   412 AVVVTVRLFLATSPPDPFGLIVPPSRKSVFIEVTALPFHTSSEGDSPTTSSEPI----KTNMYKD 472
            .:.|..|.||.:        |:      :||.|.::.       .|....::||    ..:..|.
Mouse   332 ELQVVHRAFLLS--------II------LFIVVASIL-------QSMLEIADPIVLALGASRDKS 375

  Fly   473 TYKSLNVIPLGMLLY----YIAVSDLIIKLLTMLVKLIITMLPHHLMRLKVRARLYV-------- 525
            .:|....:.|.:.|.    |:|.  :|.:...|...|:|.:....|..|:|...|::
Mouse   376 LWKHFRAVSLCLFLLVFPAYMAY--MICQFFHMDFWLLIIISSSILTSLQVLGTLFIYVLFMVEE 438

  Fly   526 -----------LVEYISQFYRAMTPITQWLLFLY---ESYSGLEVVSGGLFSAMY---------- 566
                       ::.|::..||.:..:....:..|   |:..|...|.|.:...::
Mouse   439 FRKEPVENMDDVIYYVNGTYRLLEFVVALCVVAYGVSETIFGEWTVMGSMIIFIHSYYNVWLRAQ 503

  Fly   567 LGAKIF----ELVERGKSLKKAIVTFRKNIDSERPPTKDELDAAGALCPICHDAFNTPTVLECGH 627
            ||.|.|    :.|.:.|||..|              |:::|:....:|.||:....:..:..|.|
Mouse   504 LGWKSFLLRRDAVNKIKSLPVA--------------TQEQLEKHNDICAICYQDMKSAVITPCSH 554

  Fly   628 IFCDECVQTWFKREQTCPMCRAKVSD 653
            .|...|::.|...:.|||:|...:.:
Mouse   555 FFHAGCLKKWLYVQDTCPLCHCHLKN 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13605	NP_651214.2	RING	610..651	CDD:238093	12/40 (30%)
Rnf145	NP_001350095.1	TRC8_N	8..506	CDD:372682	48/261 (18%)
		YLYF motif. /evidence=ECO:0000269\|PubMed:29374057	81..84
		HRD1	<520..627	CDD:227568	18/75 (24%)
		RING-H2_RNF145	533..575	CDD:319598	11/41 (27%)
		RING-H2 finger (C3H2C3-type)	537..574	CDD:319598	11/36 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..663
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D897451at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910