DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13605 and RNFT1

DIOPT Version :9

Sequence 1:	NP_651214.2	Gene:	CG13605 / 42858	FlyBaseID:	FBgn0039150	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_057209.3	Gene:	RNFT1 / 51136	HGNCID:	30206	Length:	435	Species:	Homo sapiens

Alignment Length:	492	Identity:	124/492 - (25%)
Similarity:	200/492 - (40%)	Gaps:	101/492 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 PAAPG----PQPAANPVDNSHILLGQQQPSMPEPVSPLRYGRVSAVSGASSAGAMGRSISLR--- 268
            |:|.|    .:|.|....:....|...|.:..:..||       ..:|:|...:..:.:..|
Human    12 PSASGHERRQRPEAKTSGSEKKYLRAMQANRSQLHSP-------PGTGSSEDASTPQCVHTRLTG 69

  Fly   269 EGEMRHNHSLNGGRHNASAIGLNSNPAAFDEREANESQDLDESDGNVENG---GGGGNPPEPAEN 330
            ||...|    :|..|    |.:||.|     :|..|    :.|..|:.:|   ...|........
Human    70 EGSCPH----SGDVH----IQINSIP-----KECAE----NASSRNIRSGVHSCAHGCVHSRLRG 117

  Fly   331 NPEDEHLISDDMVVQILSH------FVRY--------LPLIFILFFKFLHDHLLGI-VDLLVLQT 380
            :...|..::||...:...|      ..||        ||.|.||..|.:..|:.|| :.:.:|.|
Human   118 HSHSEARLTDDTAAESGDHGSSSFSEFRYLFKWLQKSLPYILILSVKLVMQHITGISLGIGLLTT 182

  Fly   381 VMYNVNRSVRNQVARLAQKNYAVMVRDTFLVAVVVTVRLFLATSPPDPFGLIVPPSRKSVFIEVT 445
            .|| .|:|:.||          |.:|:.........:.:|||.|              ||.:..|
Human   183 FMY-ANKSIVNQ----------VFLRERSSKIQCAWLLVFLAGS--------------SVLLYYT 222

  Fly   446 ALPFHTSSEGDSPTTSSEPIKTNMYKDTY---KSLNVIPLGMLLYYIAVSDLIIKLLTMLVKLII 507
               ||:.|               :|....   .:|:.:....:.:.:.::|.|:|...|.:|.:|
Human   223 ---FHSQS---------------LYYSLIFLNPTLDHLSFWEVFWIVGITDFILKFFFMGLKCLI 269

  Fly   508 TMLPHHLMRLKVRARLYVLVEYISQFYRAMTPITQWLLFLYESYSGLEVVS----GGLFSAMYLG 568
            .::|..:|..|.:...|:|:|.:.|:||...||..|..:|. ||.....|:    |.|.:.:||.
Human   270 LLVPSFIMPFKSKGYWYMLLEELCQYYRTFVPIPVWFRYLI-SYGEFGNVTRWSLGILLALLYLI 333

  Fly   569 AKIFELVERGKSLKKAIVTFRKNIDSERPPTKDELDAAGALCPICHDAFNTPTVLECGHIFCDEC 633
            .|:.|.....::.::.:..|..........:|.:......:|.||...|..|.:|.|.||||:||
Human   334 LKLLEFFGHLRTFRQVLRIFFTQPSYGVAASKRQCSDVDDICSICQAEFQKPILLICQHIFCEEC 398

  Fly   634 VQTWFKREQTCPMCRAKVSDD-PAWQDGSTTFFHQLY 669
            :..||.||:|||:||..:||. ..|:||:|:...|:|
Human   399 MTLWFNREKTCPLCRTVISDHINKWKDGATSSHLQIY 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13605	NP_651214.2	RING	610..651	CDD:238093	22/40 (55%)
RNFT1	NP_057209.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62		11/56 (20%)
		Required for ubiquitin ligase activity and for protection against ER stress-induced cell death. /evidence=ECO:0000269\|PubMed:27485036	368..419		23/50 (46%)
		RING	375..416	CDD:238093	22/40 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157421
Domainoid	1	1.000	63	1.000	Domainoid score	I10262
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003057
OrthoInspector	1	1.000	-	-		otm40719
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15860
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4029
SonicParanoid	1	1.000	-	-		X1778
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.830