DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13605 and rnft1

DIOPT Version :9

Sequence 1:	NP_651214.2	Gene:	CG13605 / 42858	FlyBaseID:	FBgn0039150	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_998393.2	Gene:	rnft1 / 406509	ZFINID:	ZDB-GENE-040426-2324	Length:	419	Species:	Danio rerio

Alignment Length:	478	Identity:	124/478 - (25%)
Similarity:	196/478 - (41%)	Gaps:	128/478 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 PSMPEPVSPLRYGR----------------------------VSAVSGASSAGAMGRSISLREGE 271
            |..|||.|  |.|.                            |....|:||....||..:.|  .
Zfish    27 PMQPEPSS--REGNGLSLTLQPELLARMPGAGSSSGTETGEDVRVPMGSSSGSTNGRGATSR--R 87

  Fly   272 MR---HNHSLNGGRHNASAIGLNSNPAAFDEREANESQDLDESDGNVENGGGGGNPPEPAENNPE 333
            ||   |:||...| |..|           .|.|:      |..:.::|:|              |
Zfish    88 MRTASHSHSHTHG-HGHS-----------HEHES------DSGESDLESG--------------E 120

  Fly   334 DEHLISDDMVVQILSHFVRY----LPLIFILFFKFLHDHLLGIVDLLVLQTVMYNVNRSVRNQVA 394
            ....||:      |.:.:|:    ||.|.||..|.:..|.||:...:.|.|....||:|::.|
Zfish   121 SSSSISE------LRYLLRWLKKSLPFIVILCAKLVIQHALGLAVAVGLFTTFMYVNKSIQTQ-- 177

  Fly   395 RLAQKNYAVMVRDTFLVAVVVTVRLFLATSPPDPFGLIVPPSRKSVFIEVTALPFHTSSEGDSPT 459
                    |.:.|.........:.|||.:|              |:.:..|   |||.|
Zfish   178 --------VFLHDRRTNLHCAWLLLFLTSS--------------SLLVFYT---FHTQS------ 211

  Fly   460 TSSEPIKTNMYKDTY---KSLNVIPLGMLLYYIAVSDLIIKLLTMLVKLIITMLPHHLMRLKVRA 521
                     :|:..:   .:::......:|:.:.|::.|:|.:.|..|.:|.::|..||..:.|.
Zfish   212 ---------LYRCLFFANATIDYHNFWEVLWSVGVTNFILKFIFMGFKCLILLVPCPLMTYRRRG 267

  Fly   522 RLYVLVEYISQFYRAMTPITQWLLFLYESYSGLE----VVSGGLFSAMYLGAKIFELVERGKSLK 582
            :.|:|:|.:.|.|:.:.|:..|..:|. ||..::    :..|.|.:.:||..|:..|.....||:
Zfish   268 QWYMLIEEVGQLYQVIAPVPLWFRYLV-SYDEMDTSVGLTLGILLALLYLIMKLLALYGLSGSLQ 331

  Fly   583 KAIVTFRKNIDSERPPTKDELDAAGALCPICHDAFNTPTVLECGHIFCDECVQTWFKREQTCPMC 647
            |.:.||.....:..|.:..::..||.:||||...|..|.||.|.||||:||:..|..:|:|||:|
Zfish   332 KTLRTFFSPEVNGAPASPAQIREAGDICPICQADFKQPRVLVCQHIFCEECIAQWLNQERTCPLC 396

  Fly   648 RAKVSDD-PAWQDGSTTFFHQLY 669
            |..::|. ..|:||:|:...|:|
Zfish   397 RTVITDKVHKWKDGATSAHLQIY 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13605	NP_651214.2	RING	610..651	CDD:238093	22/40 (55%)
rnft1	NP_998393.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..120		27/128 (21%)
		Required for ubiquitin ligase activity and for protection against ER stress-induced cell death. /evidence=ECO:0000250\|UniProtKB:Q5M7Z0	352..403		24/50 (48%)
		RING	359..400	CDD:238093	22/40 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593200
Domainoid	1	1.000	71	1.000	Domainoid score	I9410
eggNOG	1	0.900	-	-		E1_KOG4638
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I4568
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003057
OrthoInspector	1	1.000	-	-		otm24847
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15860
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4029
SonicParanoid	1	1.000	-	-		X1778
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.880