DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13605 and syvn1

DIOPT Version :9

Sequence 1:	NP_651214.2	Gene:	CG13605 / 42858	FlyBaseID:	FBgn0039150	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_997900.2	Gene:	syvn1 / 335226	ZFINID:	ZDB-GENE-030131-7166	Length:	618	Species:	Danio rerio

Alignment Length:	329	Identity:	72/329 - (21%)
Similarity:	124/329 - (37%)	Gaps:	125/329 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 HLISDDMV--------VQILSHFVRYLPLIFILFFKFLHDHLLGIVDLLVLQTVMYNVNRSVRNQ 392
            |.:::|.|        :..:.|| |.|.|:.          |||::|.|.       ||.:..:.
Zfish   117 HWLAEDRVDFMERSPNISWVFHF-RVLSLMV----------LLGVMDFLF-------VNHACHSI 163

  Fly   393 VARLAQKNYAVMVRDTFLVAVVVTVRLFLATSPPDPFGLIVPPSRKSVFIEVTALPFHT-SSEGD 456
            :.|.|    :|.:...|..|:::|:.|                   :.||:.|   .|| ..:.:
Zfish   164 ITRGA----SVQLVFGFEYAILMTMVL-------------------TTFIKYT---LHTIDLQSE 202

  Fly   457 SPTTSSEPIKTNMYKDTYKSLNVIPLGMLLYYIAVSDLIIKLLTMLVKLIITMLPHHLMRLKVRA 521
            :|..:.                           ||..|..:|.|..:|:::.|.   .|.:.::.
Zfish   203 NPWDNK---------------------------AVYMLYTELFTGFIKVLLYMA---FMTIMIKV 237

  Fly   522 RLYVLVEYISQFYRAMTPITQWLLFLYESYSGLEVVSGGLFSAMYLGAKIFELVERGKSLKKAIV 586
            ..:.|.        |:.|                         |||..:.|:     |::..||:
Zfish   238 HTFPLF--------AIRP-------------------------MYLAMRQFK-----KAVTDAIM 264

  Fly   587 TFR--KNIDSERP-PTKDELDAAGALCPICHDAFNT-PTVLECGHIFCDECVQTWFKREQTCPMC 647
            :.|  :|:::..| .|.::|.|...:|.||.:...| ...|.|.|||...|:::||:|:||||.|
Zfish   265 SRRAIRNMNTLYPDATPEDLQATDNVCIICREEMVTGAKKLPCNHIFHSSCLRSWFQRQQTCPTC 329

  Fly   648 RAKV 651
            |..|
Zfish   330 RMDV 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13605	NP_651214.2	RING	610..651	CDD:238093	19/41 (46%)
syvn1	NP_997900.2	PMT_2	21..>256	CDD:304453	42/245 (17%)
		Interaction with p53/TP53. /evidence=ECO:0000250	236..270		11/71 (15%)
		zf-RING_2	289..330	CDD:290367	17/40 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..361
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	390..434
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..487
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D897451at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920