DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13605 and Rnft2

DIOPT Version :9

Sequence 1:	NP_651214.2	Gene:	CG13605 / 42858	FlyBaseID:	FBgn0039150	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001100614.1	Gene:	Rnft2 / 304521	RGDID:	1560195	Length:	445	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	132/570 - (23%)
Similarity:	225/570 - (39%)	Gaps:	157/570 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 NSSSPVRVTTQMNRRLQQSRSMGANTGGSLE----EPSS-----AGAAGGPGASPGTAAGVRQMG 171
            :||:...:..:.:|....|.....:.||..|    ||:|     :|.|||..|||..|..|  :|
  Rat    17 HSSNTDNIPPERSRSQALSPEASVDEGGVFESLKAEPASPPTLFSGLAGGLPASPFPAGLV--LG 79

  Fly   172 FWRVNLNDVFSLSTASSTEALRSFISHSNFRYPPATTAAPAAPGPQPAANPVDNSHILLGQQQPS 236
                        |||...:.   ||                   |.||..
  Rat    80 ------------STAGGGDV---FI-------------------PMPATR--------------- 95

  Fly   237 MPEPVSPLRYGRVSAVSGASSAGAMGRSISLREGEMRH----NHSLNGGRHNASAIGLNSNPAAF 297
                               ..||  |||   .||...|    :|..:.|.|...::   ......
  Rat    96 -------------------DEAG--GRS---TEGSTYHHRQAHHHFHHGAHRGGSL---LQHVGG 133

  Fly   298 DEREANESQDLDESDGNVENGGGGGNPPEPAENNPEDEHLISDDMVVQILSHFVRYLPLIFILFF 362
            |.|..:| :.:||..|.          |.||         :|:  :..::....:.||.|.||..
  Rat   134 DHRGHSE-EGVDEQPGT----------PAPA---------LSE--LKAVICWLQKGLPFILILLA 176

  Fly   363 KFLHDHLLGIVDLLVLQTVMYNVNRSVRNQVARLAQKNYAVMVRDTFLVAVVVTVRLFLATSPPD 427
            |....|.|||...:.:.:.....|.::|.||:          :::...|.|::.:..|||.:
  Rat   177 KLCFQHKLGIAVCIGMASTFAYANSALREQVS----------LKEKRSVLVILWILAFLAGN--- 228

  Fly   428 PFGLIVPPSRKSVFIEVTALPFHTSSEGDSPTTSSEPIKTNM--YKDTYKSLNVIPLGMLLYYIA 490
                       ::::..              |.||:.:.:::  .|...::|:...   ||:.:.
  Rat   229 -----------TLYVLY--------------TFSSQQLYSSLIFLKPNLETLDFFD---LLWIVG 265

  Fly   491 VSDLIIKLLTMLVKLIITMLPHHLMRLKVRARLYVLVEYISQFYRAMTPITQWLLFLYESYSGLE 555
            ::|.::|.:|:.:|.:|..||..::.:|.:.:.|:::|.:||.:|::.||..|..::....|...
  Rat   266 IADFVLKYITIALKCLIVALPKIILAVKSKGKFYLVIEELSQLFRSLVPIQLWYKYIMGDDSSDS 330

  Fly   556 VVSGGLFSAMYLGAKIFELVERGKSLKKAIVTFRKNIDSERPPTKDELDAAGALCPICHDAFNTP 620
            ...||:...:|...|.|::..|...|:||:.....:.:.....|..:...|||:|.||...|..|
  Rat   331 YFLGGVLIILYSLCKSFDICGRVGGLRKALKLLCTSQNYGVRATGQQCTEAGAVCAICQAEFRDP 395

  Fly   621 TVLECGHIFCDECVQTWFKREQTCPMCRAKVSDD-PAWQDGSTTFFHQLY 669
            .:|.|.|:||:||:..|..||:|||:||:...|. ..|:||:|:...|:|
  Rat   396 MILLCQHVFCEECLCLWLDRERTCPLCRSVAVDTLRCWKDGATSAHLQVY 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13605	NP_651214.2	RING	610..651	CDD:238093	20/40 (50%)
Rnft2	NP_001100614.1	RING_Ubox	384..423	CDD:418438	18/38 (47%)
Rnft2	NP_001100614.1	RING-HC finger (C3HC4-type)	385..422	CDD:319361	18/36 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351396
Domainoid	1	1.000	67	1.000	Domainoid score	I9586
eggNOG	1	0.900	-	-		E1_KOG4638
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003057
OrthoInspector	1	1.000	-	-		otm44856
orthoMCL	1	0.900	-	-		OOG6_105150
Panther	1	1.100	-	-	O	PTHR15860
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1778
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.700