DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13605 and Amfr

DIOPT Version :9

Sequence 1:	NP_651214.2	Gene:	CG13605 / 42858	FlyBaseID:	FBgn0039150	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_035917.2	Gene:	Amfr / 23802	MGIID:	1345634	Length:	639	Species:	Mus musculus

Alignment Length:	414	Identity:	81/414 - (19%)
Similarity:	149/414 - (35%)	Gaps:	137/414 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 ENGGGGGNPPEP--AENNPE-------------DEHLISDDMVVQILSHFVRYLPLIFILFFKFL 365
            |:|.|   .|||  |...||             .::|:||.:.|.:|   |.....:.:|..|
Mouse    40 EDGSG---EPEPLTAPLQPEARLTAGGPRARDVAQYLLSDSLFVWVL---VNTACCVLMLVAK-- 96

  Fly   366 HDHLLGIVDLLVLQTVMYNVNRSVRNQVARLAQKNYAVMVRDTFLVAV--VVTVR------LFLA 422
                       ::|.:::...|....|..:....|: :..:..|:..|  |.||.      |:.|
Mouse    97 -----------LIQCIVFGPLRVSERQHLKDKFWNF-IFYKFIFIFGVLNVQTVEEVVMWCLWFA 149

  Fly   423 TSPPDPFGLIVPPSRKSVFIEVTALPFHTSSEGDSPTTSSEPIKTNMYKDTYKSLNVIPLGMLLY 487
                   ||        ||:.                     :...:.||.::.|:..|...:..
Mouse   150 -------GL--------VFLH---------------------LMVQLCKDRFEYLSFSPTTPMSS 178

  Fly   488 YIAVSDLIIKLLT----MLVKLIITMLPHHLMRLKVRARLYVLVEYISQFYRAMTPITQWLLFLY 548
            :..|..|:|.:|.    :.|...:|...|.:..|...|...:||.     .|....|.::::.|:
Mouse   179 HGRVLSLLIAMLLSCCGLAVVCCVTGYTHGMHTLAFMAAESLLVT-----VRTAHVILRYVIHLW 238

  Fly   549 E-----SYSG-------------LEVVS------------GGLFSAM----------YLGAKIFE 573
            :     ::.|             |.::|            |.::.:|          ||..::..
Mouse   239 DLNHEGTWEGKGTYVYYTDFVMELALLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQR 303

  Fly   574 LVERGKSLKKAIVTFRKNIDSE-RPPTKDELDAAGALCPICHDAFNTPTVLECGHIFCDECVQTW 637
            .:.|.|:..:.:    .|:::. ...|.:||......|.||.|:......|.|||:|.:.|:::|
Mouse   304 RIRRHKNYLRVV----GNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLFHNSCLRSW 364

  Fly   638 FKREQTCPMCRAKVSDDPAWQDGS 661
            .:::.:||.||..::    ..|||
Mouse   365 LEQDTSCPTCRMSLN----IADGS 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13605	NP_651214.2	RING	610..651	CDD:238093	15/40 (38%)
Amfr	NP_035917.2	HRD1	82..>378	CDD:227568	65/357 (18%)
		zf-RING_2	335..375	CDD:290367	13/39 (33%)
		CUE_AMFR	454..494	CDD:270604
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..531
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	594..620
		VCP/p97-interacting motif (VIM). /evidence=ECO:0000250\|UniProtKB:Q9UKV5	618..636
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810