DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10694 and rhp23

DIOPT Version :9

Sequence 1:	NP_651212.1	Gene:	CG10694 / 42855	FlyBaseID:	FBgn0039147	Length:	290	Species:	Drosophila melanogaster
Sequence 2:	NP_596231.1	Gene:	rhp23 / 2540481	PomBaseID:	SPBC2D10.12	Length:	368	Species:	Schizosaccharomyces pombe

Alignment Length:	370	Identity:	102/370 - (27%)
Similarity:	176/370 - (47%)	Gaps:	84/370 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKLSIRMLDQRTITL-EMNESQEVRALKQKLGNLPEVAMPAENLQLIYSGRIMEDAMPLSEYRIA 64
            |.|:.:.|.|:...: :::...::..||:|:..  :.....|..:|||||||:.|...:.||.|.
pombe     1 MNLTFKNLQQQKFVISDVSADTKISELKEKIQT--QQNYEVERQKLIYSGRILADDKTVGEYNIK 63

  Fly    65 E-DKIIVLMGKKKVDKSSPEEKVAPTP-PLAAGP------------NVLRTEDVVPSLAPNDQ-- 113
            | |.|:.::.:.|...|:|:...:|.| |.|:.|            ....|...|.:.||::.
pombe    64 EQDFIVCMVSRPKTSTSTPKSAASPAPNPPASVPEKKVEAPSSTVAESTSTTQTVAAAAPSNPDT 128

  Fly   114 ---------------------WVSDLMSMGYGEEEVRSALRASFNHPERAIEYLINGIPQEVVS- 156
                                 .|.:::.|||...||..|:||:||:|:||:|||:.|||:::::
pombe   129 TATSEAPIDANTLAVGAQRNVAVENMVEMGYERSEVERAMRAAFNNPDRAVEYLLTGIPEDILNR 193

  Fly   157 --EQGLAAIPSVQ--------TS----------------------------DQLQQLMADLNITR 183
              |:..||:.:.|        ||                            |.|..|.:.....:
pombe   194 QREESAAALAAQQQQSEALAPTSTGQPANLFEQAALSENENQEQPSNTVGDDPLGFLRSIPQFQQ 258

  Fly   184 MREMINQNPELIHRLMNRLAETDPATFEVFQRNQEELMNMISGGA---SRTPNEIEHLQITLTAE 245
            :|:::.|||:::..::.::.:.|||..:...:|.|..:.:::.||   |..|:  ..:||.:|.|
pombe   259 LRQIVQQNPQMLETILQQIGQGDPALAQAITQNPEAFLQLLAEGAEGESALPS--GGIQIQITQE 321

  Fly   246 ETAAVGRLEALGFERVMAVQAYLACDKDEQLAAEVLIRQSEEDRD 290
            |:.::.||..|||:|.:.:||||||||:|:|||..|.....|..|
pombe   322 ESESIDRLCQLGFDRNIVIQAYLACDKNEELAANYLFEHGHESED 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10694	NP_651212.1	rad23	1..284	CDD:273167	100/362 (28%)
		UBQ	1..76	CDD:294102	22/76 (29%)
		UBA1_Rad23_like	110..148	CDD:270466	18/60 (30%)
		XPC-binding	172..227	CDD:286376	11/54 (20%)
		UBA2_Rad23_like	245..282	CDD:270467	20/36 (56%)
rhp23	NP_596231.1	rad23	1..363	CDD:273167	100/365 (27%)
		RAD23_N	1..76	CDD:176400	22/76 (29%)
		UBA1_Rhp23p_like	141..187	CDD:270561	18/45 (40%)
		XPC-binding	247..302	CDD:286376	11/54 (20%)
		UBA2_Rhp23p_like	321..360	CDD:270564	21/38 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5272
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53856
OrthoFinder	1	1.000	-	-		FOG0001474
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101279
Panther	1	1.100	-	-	O	PTHR10621
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1097
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.810