DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10694 and Nos1

DIOPT Version :9

Sequence 1:NP_651212.1 Gene:CG10694 / 42855 FlyBaseID:FBgn0039147 Length:290 Species:Drosophila melanogaster
Sequence 2:NP_032738.1 Gene:Nos1 / 18125 MGIID:97360 Length:1429 Species:Mus musculus


Alignment Length:340 Identity:57/340 - (16%)
Similarity:109/340 - (32%) Gaps:148/340 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 QRTITLEMNESQEVRAL--------------------KQKLGNLPEVAMPAENLQLIYSGRIMED 54
            |:..:|..||.::.|.|                    .:.|...|.:.|||..|           
Mouse  1110 QQFASLATNEKEKQRLLVLSKGLQEYEEWKWGKNPTMVEVLEEFPSIQMPATLL----------- 1163

  Fly    55 AMPLSEYRIAEDKIIVLMGKKKVDKSSPE---EKVAPTPPLAA-------GP----------NVL 99
               |::..:.:.:...:       .|||:   ::|..|..:.:       ||          |.:
Mouse  1164 ---LTQLSLLQPRYYSI-------SSSPDMYPDEVHLTVAIVSYHTRDGEGPVHHGVCSSWLNRI 1218

  Fly   100 RTEDVVPSL---AP------NDQ------------------WVS---DLMSMG------------ 122
            :.:||||..   ||      |.|                  |..   |:...|            
Mouse  1219 QADDVVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGC 1283

  Fly   123 --------YGEEEVRSALRASF--------NHPERAIEYLINGIPQEV-------VSEQG----- 159
                    |.||.:::..:..|        ..|:|..:|:.:.:.:::       :.|||     
Mouse  1284 RQSKIDHIYREETLQAKNKGVFRELYTAYSREPDRPKKYVQDVLQEQLAESVYRALKEQGGHIYV 1348

  Fly   160 ----------LAAIPSVQTSD-QLQQLMADLNITRMREMINQNPELI------HRLMNRLAETDP 207
                      |.||..:.|.. :|.:..|.:.|:|:|:....:.::.      :.:.|||.....
Mouse  1349 CGDVTMAADVLKAIQRIMTQQGKLSEEDAGVFISRLRDDNRYHEDIFGVTLRTYEVTNRLRSESI 1413

  Fly   208 ATFEVFQRNQEELMN 222
            |..|..:::.:|:.:
Mouse  1414 AFIEESKKDTDEVFS 1428

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10694NP_651212.1 rad23 1..284 CDD:273167 57/340 (17%)
UBQ 1..76 CDD:294102 13/85 (15%)
UBA1_Rad23_like 110..148 CDD:270466 13/92 (14%)
XPC-binding 172..227 CDD:286376 11/57 (19%)
UBA2_Rad23_like 245..282 CDD:270467
Nos1NP_032738.1 Interaction with NOSIP. /evidence=ECO:0000250 1..200
PDZ_signaling 15..98 CDD:238492
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..174
PIN (nNOS-inhibiting protein) binding. /evidence=ECO:0000250 163..240
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 271..298
NOS_oxygenase_euk 300..711 CDD:238410
Calmodulin-binding 725..745
Tetrahydrobiopterin-binding. /evidence=ECO:0000250 750..769
CysJ 754..1394 CDD:223446 51/304 (17%)
Flavodoxin_1 757..930 CDD:278677
Nitric_oxide_synthase 996..1399 CDD:99799 51/309 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0.75 Normalized mean entropy S1636
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.950

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