DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syx1A and STX11

DIOPT Version :9

Sequence 1:	NP_001189276.1	Gene:	Syx1A / 42854	FlyBaseID:	FBgn0013343	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	XP_011534515.1	Gene:	STX11 / 8676	HGNCID:	11429	Length:	313	Species:	Homo sapiens

Alignment Length:	282	Identity:	80/282 - (28%)
Similarity:	153/282 - (54%)	Gaps:	10/282 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KDRLAAL---------HAAQSDDEEETEVAVNVDGHDSYMDDFFAQVEEIRGMIDKVQDNVEEVK 58
            |||||.|         .....|||.::.....|...|..::..:..:.:|:.....:..:|:.:.
Human    28 KDRLAELLDLSKQYDQQFPDGDDEFDSPHEDIVFETDHILESLYRDIRDIQDENQLLVADVKRLG 92

  Fly    59 KKHSAILSAPQTDEKTKQELEDLMADIKKNANRVRGKLKGIEQNIE-QEEQQNKSSADLRIRKTQ 122
            |:::..|::.:.....|::...:...||.....:..||:.:::..| .|.|....||..||.:.|
Human    93 KQNARFLTSMRRLSSIKRDTNSIAKAIKARGEVIHCKLRAMKELSEAAEAQHGPHSAVARISRAQ 157

  Fly   123 HSTLSRKFVEVMTEYNRTQTDYRERCKGRIQRQLEITGRPTNDDELEKMLEEGNSSVFTQGIIME 187
            ::.|:..|...|.:||:.:...|:.||.||||||||.|:..:.|::|.|.|:|...||::.::.:
Human   158 YNALTLTFQRAMHDYNQAEMKQRDNCKIRIQRQLEIMGKEVSGDQIEDMFEQGKWDVFSENLLAD 222

  Fly   188 TQQAKQTLADIEARHQDIMKLETSIKELHDMFMDMAMLVESQGEMIDRIEYHVEHAMDYVQTATQ 252
            .:.|:..|.:||:||:::::||:.|:::|::|:.||:|||.|.:.::.||.:|:..:||...|..
Human   223 VKGARAALNEIESRHRELLRLESRIRDVHELFLQMAVLVEKQADTLNVIELNVQKTVDYTGQAKA 287

  Fly   253 DTKKALKYQSKARRKKIMILIC 274
            ..:||::|:.|...:.:....|
Human   288 QVRKAVQYEEKNPCRTLCCFCC 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syx1A	NP_001189276.1	Syntaxin	33..230	CDD:395647	57/197 (29%)
Syx1A	NP_001189276.1	SNARE	231..281	CDD:399038	11/44 (25%)
STX11	XP_011534515.1	Syntaxin	67..264	CDD:279182	57/196 (29%)
		SynN	67..219	CDD:238105	41/151 (27%)
		SNARE_syntaxin11	229..291	CDD:277231	22/61 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5074
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1033833at2759
OrthoFinder	1	1.000	-	-		FOG0000185
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820