Protein Alignment Syx1A and STX19

DIOPT Version :10

• Sequence 1: NP_001189276.1
• Gene: Syx1A / 42854
• FlyBaseID: FBgn0013343
• Length: 296
• Species: Drosophila melanogaster
• Sequence 2: NP_001001850.1
• Gene: STX19 / 415117
• HGNCID: 19300
• Length: 294
• Species: Homo sapiens
• Alignment Length: 289
• Identity: 81/289 - (28%)
• Similarity: 154/289 - (53%)
• Gaps: 22/289 - (7%)

  Fly     3 KDRLAAL-------------HAAQSDDEEE---TEVAVNVDGHDSYMDDFFAQVEEIRGMIDKVQ 51
            ||||..|             |.:.::.||:   .:.|| :...:...:....::::::..|:.:.
Human     2 KDRLQELKQRTKEIELSRDSHVSTTETEEQGVFLQQAV-IYEREPVAERHLHEIQKLQESINNLA 65

  Fly    52 DNVEEVKKKHSAILSAPQTDEKTKQELEDLMADIKKNANRVRGKLKGIEQNIEQEEQQN-KSSAD 115
            |||::..::..:::::.:.....|:| ..:..:||..|..:...|..:.:.:::.|.:| .||..
Human    66 DNVQKFGQQQKSLVASMRRFSLLKRE-STITKEIKIQAEYINRSLNDLVKEVKKSEVENGPSSVV 129

  Fly   116 LRIRKTQHSTLSRKFVEVMTEYNRTQTDYRERCKGRIQRQLEITGRPTNDDELEKMLEEGNSSVF 180
            .||.|:||:.:.|.|.::|..||.|....:|:||..|.||||:.|:..:::::..||.:|...||
Human   130 TRILKSQHAAMFRHFQQIMFIYNDTIAAKQEKCKTFILRQLEVAGKEMSEEDVNDMLHQGKWEVF 194

  Fly   181 TQGIIMETQQAKQTLADIEARHQDIMKLETSIKELHDMFMDMAMLVESQGEMIDRIEYHVEHAMD 245
            .:.::.|....|..|::||.||::::.||..||:|.|:|:.:::|||.|||.|:.||..|....:
Human   195 NESLLTEINITKAQLSEIEQRHKELVNLENQIKDLRDLFIQISLLVEEQGESINNIEMTVNSTKE 259

  Fly   246 YVQTATQDTKKALKYQSKARRKKIMILIC 274
            ||....:....|:||:   :|....:|.|
Human   260 YVNNTKEKFGLAVKYK---KRNPCRVLCC 285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syx1A	NP_001189276.1	Syntaxin	35..230	CDD:459942	56/195 (29%)
		SNARE	231..281	CDD:461727	13/44 (30%)
STX19	NP_001001850.1	Syntaxin	49..244	CDD:459942	56/195 (29%)
		SNARE	212..278	CDD:473982	26/68 (38%)