Protein Alignment SMC1 and SMC5

DIOPT Version :10

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_014608.1
• Gene: SMC5 / 854123
• SGDID: S000005394
• Length: 1093
• Species: Saccharomyces cerevisiae
• Alignment Length: 1293
• Identity: 259/1293 - (20%)
• Similarity: 465/1293 - (35%)
• Gaps: 397/1293 - (30%)

  Fly     2 TEEDDDVAQRVATAPVRKPD---DETAFLEYIEMENFKSYRGHIVVGPLKQF------NAVIGPN 57
            |...:|...|.....:.|||   .:...:..|.:::|.:|       .|.:|      |.:||||
Yeast    14 THHGEDTEPRSKRVKIAKPDLSSFQPGSIIKIRLQDFVTY-------TLTEFNLSPSLNMIIGPN 71

  Fly    58 GSGKSNFMDAISFVMGEKTSSL-RVKRLNDLI-HGSSIGK---PVSRSCYVT-AKFVLNEERHMD 116
            |||||.|:.|:...:..|...: |.|::.|.| :|..:.|   .:..|..|| .:::...:..:.
Yeast    72 GSGKSTFVCAVCLGLAGKPEYIGRSKKVEDFIKNGQDVSKIEITLKNSPNVTDIEYIDARDETIK 136

  Fly   117 FQRAVIGGS--SEYRINGESVSSSTYLNKLEKIGINVKAKNFLVF--QGAVENIA-MKTPKERTA 176
            ..|.:....  |:|.||...||.|.....:.:  :|::..|...|  |..||..| :|:.|....
Yeast   137 ITRIITRSKRRSDYLINDYQVSESVVKTLVAQ--LNIQLDNLCQFLSQERVEEFARLKSVKLLVE 199

  Fly   177 LFEEISGSGL-LKDDYNRLKQEMIVAEEETQFTYQKKKGIAAERKEAKHEKMEADRYTRLQNEYN 240
            ....|..|.| :.|:...|:......:::..|   ||..|...|:|:...:...:.....||:..
Yeast   200 TIRSIDASLLDVLDELRELQGNEQSLQKDLDF---KKAKIVHLRQESDKLRKSVESLRDFQNKKG 261

  Fly   241 EKQVEYQLFRLFHVERDIRKFTSDLEVRQQEVKAVEQRKEAADEILREKKKDAG-KITRDLAKID 304
            |.::..||.....|:....|    |.:.::|   .|:.|.....||::||..|. |.|     ::
Yeast   262 EIELHSQLLPYVKVKDHKEK----LNIYKEE---YERAKANLRAILKDKKPFANTKKT-----LE 314

  Fly   305 QEIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKTLETAREADNAHQSDIRKLEKQLADVEAL 369
            .::.|...:.:.:...::|||||:....:||.:::..:...:..:..::...:||:   |.:.:.
Yeast   315 NQVEELTEKCSLKTDEFLKAKEKINEIFEKLNTIRDEVIKKKNQNEYYRGRTKKLQ---ATIIST 376

  Fly   370 KKRF-------------EDEIENESQRRGKSVNMEEGLVQEYDRLKQEAEATATQYRSELDSVNR 421
            |:.|             |..:..:...:.|.:..:||.:::   |..|.:|.|.....|:.|:.|
Yeast   377 KEDFLRSQEILAQTHLPEKSVFEDIDIKRKEIINKEGEIRD---LISEIDAKANAINHEMRSIQR 438

  Fly   422 EQKSEQDTLD-----GETNRRASVEESFKKLTLQREEAVKRRDKLMDHIKSSQAALEEQNRIKDE 481
            :.:|:..:|.     |..|:...::|....:.:.||.. :.:||:::....:.:|:..|......
Yeast   439 QAESKTKSLTTTDKIGILNQDQDLKEVRDAVLMVREHP-EMKDKILEPPIMTVSAINAQFAAYLA 502

  Fly   482 LRRDVGTSK------------------EKIAEKQREL-----------EDVRD-----QLGD-AK 511
            ...|..|||                  :|.....|||           |.|||     .|.| ..
Yeast   503 QCVDYNTSKALTVVDSDSYKLFANPILDKFKVNLRELSSADTTPPVPAETVRDLGFEGYLSDFIT 567

  Fly   512 SDKHEDARRKKKQEVVELFKKQVPGVYDRMINMCQPTHKRYNVAVT------------------- 557
            .||                         |::.|...|.|.:.:.|:
Yeast   568 GDK-------------------------RVMKMLCQTSKIHTIPVSRRELTPAQIKKLITPRPNG 607

  Fly   558 KVLGKFMEAI----IVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPLKERLRNI-SDPRNVR 617
            |:|  |...|    :||.:::|....|:           .|.| :.:|.......:| |:.:.:|
Yeast   608 KIL--FKRIIHGNRLVDIKQSAYGSKQV-----------FPTD-VSIKQTNFYQGSIMSNEQKIR 658

  Fly   618 LVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALALDGTFYQKSGL----- 677
            :..:::.                          :|..|...:|..|||:     .||||.
Yeast   659 IENEIIN--------------------------LKNEYNDRKSTLDALS-----NQKSGYRHELS 692

  Fly   678 -ISGGSHDLARKAKRWDE--KHMAQLKMQKERLQEELKELVKKSRK--QSELATVESQIKGLENR 737
             ::..:.|:.|:|.:.:|  |.....|...|.|:|:|.:|.:::||  ..::..::.||:.|..:
Yeast   693 ELASKNDDINREAHQLNEIRKKYTMRKSTIETLREKLDQLKREARKDVSQKIKDIDDQIQQLLLK 757

  Fly   738 LKYSMVDLESSKKSISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIKENMNNVEDKVY 802
            .::.:..:.||.||:.....:|...|         ||:.|         .|.:..:||:|
Yeast   758 QRHLLSKMASSMKSLKNCQKELISTQ---------ILQFE---------AQNMDVSMNDV----- 799

  Fly   803 ASFCRRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSINSQLDFEKQKDTKKNVERWERSVQD 867
                  :|..|.|   |.:|..|.|..:|                |.|:.......:.|.|.::.
Yeast   800 ------IGFFNER---EADLKSQYEDKKK----------------FVKEMRDTPEFQSWMREIRS 839

  Fly   868 -EEDALEGLKLAEARYLKEIDEDKEKMEKFKQDKQAKKQAVDDMEEDISKARKDVANLAKEIHNV 931
             ::|..|.|.....:|    :|:......|.||      .:|.:|.:|:....|
Yeast   840 YDQDTKEKLNKVAEKY----EEEGNFNLSFVQD------VLDKLESEIAMVNHD----------- 883

  Fly   932 GSHLSAVESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVRQSDPDVPSTSAAMENIIEVDY 996
                   ||.:        .||.|...:              :|:.:..||..|..:|.|
Yeast   884 -------ESAV--------TILDQVTAE--------------LRELEHTVPQQSKDLETI----- 914

  Fly   997 SSLPREYTKLKDDSAFKKTHEMLQKDLQSKLDVLERIQTPNMKALQKLDAVTEKVQSTNEEFENA 1061
                  ..|||:|.|                 |||          .|||.:..|:
Yeast   915 ------KAKLKEDHA-----------------VLE----------PKLDDIVSKI---------- 936

  Fly  1062 RKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEAAQAYIGPDNPEEPYLDG--- 1123
                              |:||.               :|..|..:...:..:.|:: |.:.
Yeast   937 ------------------SARFA---------------RLFNNVGSAGAVRLEKPKD-YAEWKIE 967

  Fly  1124 --INYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTN 1179
              :.:...||.|:.. .:..||||:.::.:..:.:...|..|||.|:|||:..:|:.|
Yeast   968 IMVKFRDNAPLKKLD-SHTQSGGERAVSTVLYMIALQEFTSAPFRVVDEINQGMDSRN 1024

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	SMC_N	26..1222	CDD:481474	253/1266 (20%)
SMC5	NP_014608.1	P-loop containing Nucleoside Triphosphate Hydrolases	40..>198	CDD:476819	44/166 (27%)
		SMC_N	42..1048	CDD:481474	253/1265 (20%)
		Smc5_CC_C	739..811	CDD:467855	20/103 (19%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<956..1072	CDD:476819	19/71 (27%)