DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC1 and SMC3

DIOPT Version :9

Sequence 1:NP_651211.2 Gene:SMC1 / 42853 FlyBaseID:FBgn0040283 Length:1238 Species:Drosophila melanogaster
Sequence 2:NP_012461.1 Gene:SMC3 / 853371 SGDID:S000003610 Length:1230 Species:Saccharomyces cerevisiae


Alignment Length:1351 Identity:300/1351 - (22%)
Similarity:562/1351 - (41%) Gaps:323/1351 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 FLEYIEMENFKSYRGHIVVGPLKQF-NAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIH 89
            :::.:.::.||:||...::...... |.:||.||||||||..||.||:.:..|:|:.:....|||
Yeast     2 YIKRVIIKGFKTYRNETIIDNFSPHQNVIIGSNGSGKSNFFAAIRFVLSDDYSNLKREERQGLIH 66

  Fly    90 GSSIGKPVSRSCYVTAKFVLNEERH---------------MDFQRAVIGGSSEYRINGESVSSST 139
            ..|.|..:|.|    .:.|.::..|               :..:|.|.....:|::|..:|:...
Yeast    67 QGSGGSVMSAS----VEIVFHDPDHSMILPSGVLSRGDDEVTIRRTVGLKKDDYQLNDRNVTKGD 127

  Fly   140 YLNKLEKIGINVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEE 204
            .:..||..|.::.....:|.||.:..:.....|||..|.|::.|:   |....:||..:...||.
Yeast   128 IVRMLETAGFSMNNPYNIVPQGKIVALTNAKDKERLQLLEDVVGA---KSFEVKLKASLKKMEET 189

  Fly   205 TQFTYQ--KKKG-IAAERKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLE 266
            .|...|  |:.| :.::..|.:.|:.|.::|..|  |.|.|..::.|:     :|::        
Yeast   190 EQKKIQINKEMGELNSKLSEMEQERKELEKYNEL--ERNRKIYQFTLY-----DREL-------- 239

  Fly   267 VRQQEVKAVEQRKEAADEILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHC 331
                            :|::.:.::..|.....:...:|.|:|.:           |.::.:...
Yeast   240 ----------------NEVINQMERLDGDYNNTVYSSEQYIQELD-----------KREDMIDQV 277

  Fly   332 KKKLISLQKTLETAREADNAHQSDIRKLE--KQLADVEALKKRFEDEIE-NESQRRGKSVNMEE- 392
            .|||.|::.:|: .:.|.:..|:.:|:.|  ::|.:|....|..:.:|| ||.||...|..::| 
Yeast   278 SKKLSSIEASLK-IKNATDLQQAKLRESEISQKLTNVNVKIKDVQQQIESNEEQRNLDSATLKEI 341

  Fly   393 ------------GLVQEYDRL-KQEAEATATQYRSELDSVNREQ---------------KSEQDT 429
                        .::..|..| |:||     .|:.:|.|:.::|               |.|:||
Yeast   342 KSIIEQRKQKLSKILPRYQELTKEEA-----MYKLQLASLQQKQRDLILKKGEYARFKSKDERDT 401

  Fly   430 -LDGETNRRASVEESFKKL--TLQREEAVKRR---------DKLMDHIK--SSQAALE----EQN 476
             :..|.....|..::..:|  .||.:....|:         ::|:|.|.  .::..||    |..
Yeast   402 WIHSEIEELKSSIQNLNELESQLQMDRTSLRKQYSAIDEEIEELIDSINGPDTKGQLEDFDSELI 466

  Fly   477 RIKDELRRDVGTSKEKIAEKQRELEDVRDQLGDAKSDKHEDARRKKK-------------QEVVE 528
            .:|.:|...:.|.|| :..|:::|:.|.:.|   .||.:::.|...:             :|:.|
Yeast   467 HLKQKLSESLDTRKE-LWRKEQKLQTVLETL---LSDVNQNQRNVNETMSRSLANGIINVKEITE 527

  Fly   529 LFK---KQVPGVYDRMINMCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVE 590
            ..|   :.|.|....:|.:    :.:|......:.|..:..|:||||:||    .::..::..::
Yeast   528 KLKISPESVFGTLGELIKV----NDKYKTCAEVIGGNSLFHIVVDTEETA----TLIMNELYRMK 584

  Fly   591 ----TFLPLDYLQVKPLKERLRNISDPRN--VRLVFDVL----KFEPQEIERAVLFATGNALVCE 645
                ||:||:.|.:.      .::..|.|  .::.|..|    |:||: .|:||....|..:|.:
Yeast   585 GGRVTFIPLNRLSLD------SDVKFPSNTTTQIQFTPLIKKIKYEPR-FEKAVKHVFGKTIVVK 642

  Fly   646 TPEDAMKVAYEIDRSRFDALALDGTFYQKSGLISGGSHDLARKAKRWDEKHMAQLKMQKERLQEE 710
            .....:|:|   .:.:.:|:.|||....|.|:::||..|..::.:....|::.:.:.|.:::.||
Yeast   643 DLGQGLKLA---KKHKLNAITLDGDRADKRGVLTGGYLDQHKRTRLESLKNLNESRSQHKKILEE 704

  Fly   711 LKELVKKSRKQSELATVESQIKGLENRLKYSMVDLESSKKSISQYDNQLQQVQSQ---LDE-FGP 771
            | :.|:     :||..::::|..:...::....|.||...:|..|...|...:::   |:| ...
Yeast   705 L-DFVR-----NELNDIDTKIDQVNGNIRKVSNDRESVLTNIEVYRTSLNTKKNEKLILEESLNA 763

  Fly   772 KILEIERRMQNREEHIQEIKENMNNVEDKVYASFCRRLGVKNIRQYEERELVMQQERARKRAEFE 836
            .||::|:...||    ...:|.:|..|:                                  :..
Yeast   764 IILKLEKLNTNR----TFAQEKLNTFEN----------------------------------DLL 790

  Fly   837 QQIDSINSQLDFEKQKDTKKNVERWERSVQDEEDALEGLKLAEARYLKEID----EDKEKMEKFK 897
            |:.||..|:.:.|:.:...|.:......:....|||||:...       ||    |.:.|:...:
Yeast   791 QEFDSELSKEEKERLESLTKEISAAHNKLNITSDALEGITTT-------IDSLNAELESKLIPQE 848

  Fly   898 QDKQAKKQAVDD-----MEEDISKARKDVANLAKEIHNVGSHLSAVESKIEA------------- 944
            .|.::|...|.|     :::::.:.:.:..::.|:..|....|..|:.:||:             
Yeast   849 NDLESKMSEVGDAFIFGLQDELKELQLEKESVEKQHENAVLELGTVQREIESLIAEETNNKKLLE 913

  Fly   945 KKNERQNILLQ--------------AKTDCIV-----------VPLLRGSLDDAVRQSDPDVPST 984
            |.|.:|.:||:              .||..:.           :.||.   :||:.....|:.|.
Yeast   914 KANNQQRLLLKKLDNFQKSVEKTMIKKTTLVTRREELQQRIREIGLLP---EDALVNDFSDITSD 975

  Fly   985 SAAME-NIIEVDYSSLPREYTKLKDDSAFKKTHEMLQKDLQSKLDVLER----IQTPNMK-ALQK 1043
            ..... |.:..:.|.|.....:..::  |||.:|. :|||..:...|:.    ||...:| ..||
Yeast   976 QLLQRLNDMNTEISGLKNVNKRAFEN--FKKFNER-RKDLAERASELDESKDSIQDLIVKLKQQK 1037

  Fly  1044 LDAVTEKVQSTNEEFENARKKAKRAKAAFERV------------KNERSSRFVACCQHISDAIDG 1096
            ::||....|..:|.||          |.|||:            ||:.::      .| .::|| 
Yeast  1038 VNAVDSTFQKVSENFE----------AVFERLVPRGTAKLIIHRKNDNAN------DH-DESID- 1084

  Fly  1097 IYKKLARNEAAQAYIGPDNPEEPYLDGINYNCVAPGKRFQPMN--NLSGGEKTIAALALLFSTHS 1159
            :......||:..   |.|:  |....|::.:.....|:.:.::  .||||:||:.|:||:.:...
Yeast  1085 VDMDAESNESQN---GKDS--EIMYTGVSISVSFNSKQNEQLHVEQLSGGQKTVCAIALILAIQM 1144

  Fly  1160 FHPAPFFVLDEIDAALDNTNIGKVASYIRDHTTNLQTIVISLKEEFYGHAD 1210
            ..||.|::.||||||||......||:.:::.:.|.|.|..:.:.:....||
Yeast  1145 VDPASFYLFDEIDAALDKQYRTAVATLLKELSKNAQFICTTFRTDMLQVAD 1195

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC1NP_651211.2 Smc 26..1216 CDD:224117 300/1351 (22%)
ABC_SMC1_euk 27..>171 CDD:213242 41/159 (26%)
SMC_hinge 535..653 CDD:214944 28/127 (22%)
DUF4700 <697..>810 CDD:292399 24/116 (21%)
ABC_SMC1_euk <1130..1232 CDD:213242 28/83 (34%)
SMC3NP_012461.1 Smc 1..1221 CDD:224117 300/1351 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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