Protein Alignment SMC1 and SMC6

DIOPT Version :10

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_013487.1
• Gene: SMC6 / 851099
• SGDID: S000004375
• Length: 1114
• Species: Saccharomyces cerevisiae
• Alignment Length: 1314
• Identity: 260/1314 - (19%)
• Similarity: 495/1314 - (37%)
• Gaps: 404/1314 - (30%)

  Fly     5 DDDVAQR----VATAPVRKPDDETAFLE-----YIE---MENFKSYRGHIVVGPLKQFNAVIGPN 57
            |:|...|    ||||      |:..|||     ||:   :.||..:. |..:....:.|.::|.|
Yeast    54 DEDSGFRSSSDVATA------DQDNFLEESPSGYIKKVILRNFMCHE-HFELELGSRLNFIVGNN 111

  Fly    58 GSGKSNFMDAISFVMGEKTSSLRVKRLNDLIHGSSIGKPVSRSCYVTAKFVLNEERHMD------ 116
            |||||..:.||:..:|.|.|...        .|||:...:...|| :||.:|    |:|
Yeast   112 GSGKSAILTAITIGLGAKASETN--------RGSSLKDLIREGCY-SAKIIL----HLDNSKYGA 163

  Fly   117 FQRAVIG------------GSSEYRI---NGESVSSSTYLNKLEKIG-----INVKAKN---FLV 158
            :|:.:.|            |.:.:.:   ||:.:|     ||.:.|.     .:|...|   ||.
Yeast   164 YQQGIFGNEIIVERIIKRDGPASFSLRSENGKEIS-----NKKKDIQTVVDYFSVPVSNPMCFLS 223

  Fly   159 FQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMI--VAEEETQFTYQKKKGIAAERKE 221
            ...|...:...|.:::.:.|  :.|:.|.:...|.|....|  .|:|......:..|.:.||.::
Yeast   224 QDAARSFLTASTSQDKYSHF--MKGTLLQEITENLLYASAIHDSAQENMALHLENLKSLKAEYED 286

  Fly   222 AKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQEVKAVEQRKEAADEIL 286
            ||....|.::    .::.||:::..|...|:   .|:...|...:..:.|:..::|:.:...|.:
Yeast   287 AKKLLRELNQ----TSDLNERKMLLQAKSLW---IDVAHNTDACKNLENEISGIQQKVDEVTEKI 344

  Fly   287 REKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKTLETAREADNA 351
            |.:::...:.|.|...|:.:|        ..:.:|:                       .|.|:.
Yeast   345 RNRQEKIERYTSDGTTIEAQI--------DAKVIYV-----------------------NEKDSE 378

  Fly   352 HQSDIRKLEKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLVQEYDRLKQEAEATATQYRSEL 416
            || :.|:|   |.||   |.|||.|..|::                      ||::...|.|.::
Yeast   379 HQ-NAREL---LRDV---KSRFEKEKSNQA----------------------EAQSNIDQGRKKV 414

  Fly   417 DSVNREQKSEQDTLDGETNRRASVEESFKK--------LTLQREEAVKRRDKLMD----HIKSSQ 469
            |::|:       |:       |.:||...|        :..:.|:..|..:||.:    .:.|.|
Yeast   415 DALNK-------TI-------AHLEEELTKEMGGDKDQMRQELEQLEKANEKLREVNNSLVVSLQ 465

  Fly   470 AALEEQNRIKDELRRDVGTSKEKIAEKQRELEDVRDQLGDAKS--------DKHEDARRKKKQEV 526
            ....|:..|:.|...::.|....|..|:.||:::      ||.        |::.|...:..::.
Yeast   466 DVKNEERDIQHERESELRTISRSIQNKKVELQNI------AKGNDTFLMNFDRNMDRLLRTIEQR 524

  Fly   527 VELFKKQVPGVYDRMINMCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVET 591
            ...|:....|....::.: :...:::..::.:.:...:.|.:|...|..|....|::.  ..:.:
Yeast   525 KNEFETPAIGPLGSLVTI-RKGFEKWTRSIQRAISSSLNAFVVSNPKDNRLFRDIMRS--CGIRS 586

  Fly   592 FLPL--------DYLQVKPLKERLRNISDPRNVRLVFDVLKFEPQE----------IERAVLFAT 638
            .:|:        ||     .|.|...     |...:.|.|:|...|          |||.||.
Yeast   587 NIPIVTYCLSQFDY-----SKGRAHG-----NYPTIVDALEFSKPEIECLFVDLSRIERIVLI-- 639

  Fly   639 GNALVCETPEDAMKVAYEIDRSRFD---ALALDGTFYQKSGLISGGSHDLARKAKRWDEKHMAQL 700
                     ||..:....:.|:..:   ||:|..   ::||....|.:.|  ....:.:|...::
Yeast   640 ---------EDKNEARNFLQRNPVNVNMALSLRD---RRSGFQLSGGYRL--DTVTYQDKIRLKV 690

  Fly   701 KMQKERLQEELKELVKKSRKQSELATVESQIKGLENRLKYSMVDLESSKKSISQYDNQLQQVQSQ 765
            ....:...:.||:|:::..|         :::.:.:|                 |:.:|.:|:|:
Yeast   691 NSSSDNGTQYLKDLIEQETK---------ELQNIRDR-----------------YEEKLSEVRSR 729

  Fly   766 LDEFGPKILEIERRMQNREEHIQEIKENMNNVEDKVYASFCRRLGVKNIRQYEERELVMQQERAR 830
            |.|...::...:..|:.....:.|:|.|:..|.|         .|:.|.:..|.:    .||:|
Yeast   730 LKEIDGRLKSTKNEMRKTNFRMTELKMNVGKVVD---------TGILNSKINERK----NQEQA- 780

  Fly   831 KRAEFEQQIDSINSQLD--FEKQKDTKKNVERWERSVQDEEDALEGLKLAEARYLKEIDEDKEKM 893
             .|.:|...:.:..:::  .::.:..|:..:..:.::.:.:|.|:.||       ::|:..:.|:
Yeast   781 -IASYEAAKEELGLKIEQIAQEAQPIKEQYDSTKLALVEAQDELQQLK-------EDINSRQSKI 837

  Fly   894 EKFKQDK---QAKKQAVDDMEEDISKARKDVANLAKEIHNVGSHLSAVESKIEAKKNER-QNILL 954
            :|:|.|.   :.||:.   ..|:|.|...:||.|.:.|.....:..|..||      || :|:
Yeast   838 QKYKDDTIYYEDKKKV---YLENIKKIEVNVAALKEGIQRQIQNACAFCSK------ERIENV-- 891

  Fly   955 QAKTDCIVVPLLRGSLDDAVRQSDPDVPSTSAAMENIIEVDYSSLPREYTKLKDDSAFKKTHEML 1019
                                     |:|.|
Yeast   892 -------------------------DLPDT----------------------------------- 896

  Fly  1020 QKDLQSKLDVLERIQTPNMKAL----QKLDAVTEKVQSTNEEFENARKKAKRAKAAFERVKNERS 1080
            |::::.:||.:.|:.....|:|    :::.|:.||.::   :::..:||......|..|:.|...
Yeast   897 QEEIKRELDKVSRMIQKAEKSLGLSQEEVIALFEKCRN---KYKEGQKKYMEIDEALNRLHNSLK 958

  Fly  1081 SRFVACCQHISDAIDGI-------------YKKLARN-------EAAQAYIGPDNPEEPYLDGIN 1125
            :|    .|:..:|..|.             .:|.:.|       ::.:.||...|.|
Yeast   959 AR----DQNYKNAEKGTCFDADMDFRASLKVRKFSGNLSFIKDTKSLEIYILTTNDE-------- 1011

  Fly  1126 YNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTN--IGK--VASY 1186
                    :.:.::.||||||:.:.:|||.:|.....:....|||.|..:|..|  ||.  :...
Yeast  1012 --------KARNVDTLSGGEKSFSQMALLLATWKPMRSRIIALDEFDVFMDQVNRKIGTTLIVKK 1068

  Fly  1187 IRDHTTNLQTIVIS 1200
            ::| ....|||:|:
Yeast  1069 LKD-IARTQTIIIT 1081

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	SMC_N	26..1222	CDD:481474	252/1289 (20%)
SMC6	NP_013487.1	P-loop containing Nucleoside Triphosphate Hydrolases	82..>237	CDD:476819	42/173 (24%)
		SMC_prok_B	107..953	CDD:274008	208/1103 (19%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<1006..1108	CDD:476819	25/93 (27%)