DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC1 and SMC4

DIOPT Version :9

Sequence 1:	NP_651211.2	Gene:	SMC1 / 42853	FlyBaseID:	FBgn0040283	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_013187.1	Gene:	SMC4 / 850775	SGDID:	S000004076	Length:	1418	Species:	Saccharomyces cerevisiae

Alignment Length:	1367	Identity:	344/1367 - (25%)
Similarity:	620/1367 - (45%)	Gaps:	262/1367 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 FLEYIEMENFKSYRGHIVVGPL-KQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIH 89
            |:..:.:||||||.|..||||. ..|:||:|||||||||.:|::.||.|.:.:.:|..||:||||
Yeast   155 FINELVLENFKSYAGKQVVGPFHTSFSAVVGPNGSGKSNVIDSMLFVFGFRANKMRQDRLSDLIH 219

  Fly    90 GSSIGKPVSRSCYVTAKFV-----------LNEERH--MDFQRAVIGGSSEYRINGESVSSSTYL 141
            .|. ..|..:||.|...|.           ::||:.  :..::|....||:|.|| |..||.|.:
Yeast   220 KSE-AFPSLQSCSVAVHFQYVIDESSGTSRIDEEKPGLIITRKAFKNNSSKYYIN-EKESSYTEV 282

  Fly   142 NKLEK-IGINVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLK--------DDYNRLKQE 197
            .||.| .||::..|.||:.||.|||||...||.     |:.|..|||:        .:|..|.:|
Yeast   283 TKLLKNEGIDLDHKRFLILQGEVENIAQMKPKA-----EKESDDGLLEYLEDIIGTANYKPLIEE 342

  Fly   198 M---------IVAEEETQFTYQKKKGIAAERKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFH 253
            .         :..|:|.:|          |..:.:...:|:.:.|.|:....|||:.....:||.
Yeast   343 RMGQIENLNEVCLEKENRF----------EIVDREKNSLESGKETALEFLEKEKQLTLLRSKLFQ 397

  Fly   254 VE--RDIRKFTSDLEVRQQEVKAVEQRK-------EAADEILREKKKDAGKITRDLAK---IDQE 306
            .:  :...|..|.||......|.:|..|       :..|||..::|:...:|:...:|   :..|
Yeast   398 FKLLQSNSKLASTLEKISSSNKDLEDEKMKFQESLKKVDEIKAQRKEIKDRISSCSSKEKTLVLE 462

  Fly   307 IREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKTLETAREADN----------AHQSDIRK--- 358
            .||.|   ..|..|..:.|..|:..:|...:|:.|..:..||:|          .|:::|:.
Yeast   463 RRELE---GTRVSLEERTKNLVSKMEKAEKTLKSTKHSISEAENMLEELRGQQTEHETEIKDLTQ 524

  Fly   359 -LEKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLVQEYDRLKQEAEATATQYRSELDSVNRE 422
             |||:.:.::.:|...:|:.:|.|    ..:...|..::.:|...||.|:......|||..:...
Yeast   525 LLEKERSILDDIKLSLKDKTKNIS----AEIIRHEKELEPWDLQLQEKESQIQLAESELSLLEET 585

  Fly   423 Q---KSEQDTLDGETNRRASVEESFKKLTLQREEAVKRRDKLMDHIKSSQAALEEQNRIKDEL-- 482
            |   |...:||:             :|:..::....:.:|.::|..|       :.|.:|||.
Yeast   586 QAKLKKNVETLE-------------EKILAKKTHKQELQDLILDLKK-------KLNSLKDERSQ 630

  Fly   483 -RRDVGTSKEKIAEKQRELEDVRDQLGDAKSDKHEDARRKKKQEVVELFKK--QVPGVYDRMINM 544
             .::..::..|:.|.|:.|...|.:..:|:|...:...:.|....:...:|  ::.|.:.|:.::
Yeast   631 GEKNFTSAHLKLKEMQKVLNAHRQRAMEARSSLSKAQNKSKVLTALSRLQKSGRINGFHGRLGDL 695

  Fly   545 CQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPLKERLRN 609
             ......::||::....: ::.::|||.:.|:|||..|::..|....|:.||.|:    :..|:.
Yeast   696 -GVIDDSFDVAISTACPR-LDDVVVDTVECAQHCIDYLRKNKLGYARFILLDRLR----QFNLQP 754

  Fly   610 ISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALALDGTFYQK 674
            ||.|.||..:||::|.:..:...|......:.||.:..:.|..|||  .:.||..:.:||.....
Yeast   755 ISTPENVPRLFDLVKPKNPKFSNAFYSVLRDTLVAQNLKQANNVAY--GKKRFRVVTVDGKLIDI 817

  Fly   675 SGLISGGSHDLAR--------KAKRWDEKHMAQL-KMQKE----------------RLQEELKEL 714
            ||.:|||.:.:|:        ::.:.|:....:: |:::|                .::||||:|
Yeast   818 SGTMSGGGNHVAKGLMKLGTNQSDKVDDYTPEEVDKIERELSERENNFRVASDTVHEMEEELKKL 882

  Fly   715 ----------VKKSRKQ-----SELATVESQIKGLENRLKYSMVDLESSKKSISQYDNQLQQVQS 764
                      :.|:..:     |||...|.|:|  |..:.|  |...|.|..::.....|::::.
Yeast   883 RDHEPDLESQISKAEMEADSLASELTLAEQQVK--EAEMAY--VKAVSDKAQLNVVMKNLERLRG 943

  Fly   765 QLDEFGPKILEIERRMQNREEHIQE---IKENMNNVEDKVYASFCRRLGVKNIRQYEERELVMQQ 826
            :.::...:....:.:::..::.|.:   ||..|.|  .|| .|.|::|.:          ||.:.
Yeast   944 EYNDLQSETKTKKEKIKGLQDEIMKIGGIKLQMQN--SKV-ESVCQKLDI----------LVAKL 995

  Fly   827 ERARKRA--------EFEQQIDSINSQLDFEKQKDTKKNVERWERSVQDEEDALEGLKLAEARYL 883
            ::.:..:        :|::.:.  ||:.|.|...|..|.:          |:.|:..|||.|...
Yeast   996 KKVKSASKKSGGDVVKFQKLLQ--NSERDVELSSDELKVI----------EEQLKHTKLALAEND 1048

  Fly   884 KEIDEDKEKMEKFKQDKQAKKQAVDDMEEDISKARKDVANLAKEIHNVGSHLSAVESKIEAKKNE 948
            ..::|......:.|:..:..|:.::||||.|::.:.....:..::..:.|.|:.::|:|..::..
Yeast  1049 TNMNETLNLKVELKEQSEQLKEQMEDMEESINEFKSIEIEMKNKLEKLNSLLTYIKSEITQQEKG 1113

  Fly   949 RQNILLQAKTDCIVVPLLRGSLDDAVRQSDPDVPSTSAAMENIIEVD--YSSL-PREYTKLKD-D 1009
            ...:.::..|..:      |.||      |..:.|....::|..|:|  |.|. .::.:::|| :
Yeast  1114 LNELSIRDVTHTL------GMLD------DNKMDSVKEDVKNNQELDQEYRSCETQDESEIKDAE 1166

  Fly  1010 SAFKKTHEM---------------LQKDLQSKLDVLERIQTPNMKALQKLDAVTEKVQSTN---- 1055
            ::....|.|               |.:|...:||| |.|::       |::.::..|:.||
Yeast  1167 TSCDNYHPMNIDETSDEVSRGIPRLSEDELRELDV-ELIES-------KINELSYYVEETNVDIG 1223

  Fly  1056 --EEF--------------ENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARN 1104
              ||:              .||.:|....|.....:|.:|...|:|....||..:..:|:.:...
Yeast  1224 VLEEYARRLAEFKRRKLDLNNAVQKRDEVKEQLGILKKKRFDEFMAGFNIISMTLKEMYQMITMG 1288

  Fly  1105 EAAQAYIGPDNPEEPYLDGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLD 1169
            ..|:..:  .:..:|:.:|:.::.:.|.|.::.:.||||||||:::|||:|:.|.:.|.|.:|:|
Yeast  1289 GNAELEL--VDSLDPFSEGVTFSVMPPKKSWRNITNLSGGEKTLSSLALVFALHKYKPTPLYVMD 1351

  Fly  1170 EIDAALDNTNIGKVASYIRDHTTNLQTIVISLKEEFYGHADALVGITPGEG---DCLVSNVYIMD 1231
            |||||||..|:..||:||::.|.|.|.|||||:...:..|..|||:...:.   ...:.|:.|::
Yeast  1352 EIDAALDFRNVSIVANYIKERTKNAQFIVISLRNNMFELAQQLVGVYKRDNRTKSTTIKNIDILN 1416

  Fly  1232 LT 1233
            .|
Yeast  1417 RT 1418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	341/1345 (25%)
		ABC_SMC1_euk	27..>171	CDD:213242	67/158 (42%)
		SMC_hinge	535..653	CDD:214944	30/117 (26%)
		DUF4700	<697..>810	CDD:292399	29/147 (20%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	45/104 (43%)
SMC4	NP_013187.1	Smc	154..1418	CDD:224117	343/1365 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810