Protein Alignment SMC1 and SMC2

DIOPT Version :9

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_116687.1
• Gene: SMC2 / 850589
• SGDID: S000001927
• Length: 1170
• Species: Saccharomyces cerevisiae
• Alignment Length: 1310
• Identity: 291/1310 - (22%)
• Similarity: 567/1310 - (43%)
• Gaps: 255/1310 - (19%)

  Fly    27 LEYIEMENFKSYRGHIVV---GPLKQFNAVIGPNGSGKSNFMDAISFVMG-EKTSSLRVKRLNDL 87
            :|.:.::.||||....|:   .|  ||||:.|.|||||||.:|||.||:| ...|::|...|.||
Yeast     3 VEELIIDGFKSYATRTVITDWDP--QFNAITGLNGSGKSNILDAICFVLGIASMSTVRASSLQDL 65

  Fly    88 IH----------------------GSSIGKPVSRSCYVTAKFVLNEERHMDFQRAVIGGSSEYRI 130
            |:                      .|.||...|....||             ::.|:||:|:|.|
Yeast    66 IYKRGQAGVTKASVTIVFDNTDKSNSPIGFTNSPQISVT-------------RQVVLGGTSKYLI 117

  Fly   131 NGESVSSSTYLNKLEKIGINVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLK 195
            ||......:.|...:.:.:|:...|||:.||.:..:....|.|..:|.||.:|:.:.:|  .|.|
Yeast   118 NGHRAPQQSVLQLFQSVQLNINNPNFLIMQGKITKVLNMKPSEILSLIEEAAGTKMFED--RREK 180

  Fly   196 QEMIVAEEETQFTYQKKKGIAAERKEAKHEKMEADRYTRLQNEYNEKQ----------VEYQLFR 250
            .|..::::||:.  |:.:.:..|..|.|.||:..::  |:..|:...|          |.|:.:.
Yeast   181 AERTMSKKETKL--QENRTLLTEEIEPKLEKLRNEK--RMFLEFQSTQTDLEKTERIVVSYEYYN 241

  Fly   251 LFHVERDIRKFTSDLEVRQQEVKAVEQRKEAADEILREKKKDAGKITRDLAKIDQEIREFETQMN 315
            :.|....||:...:.|.|.              ::|.|..|   |.:.::..:::::.|.:.|
Yeast   242 IKHKHTSIRETLENGETRM--------------KMLNEFVK---KTSEEIDSLNEDVEEIKLQ-- 287

  Fly   316 KRRPLYIKAKEKVTHCKKKLISLQKTLETAREADNAHQSDIRKLEKQLA-------DVEALKKRF 373
                     |||..|       .:.|:......:|...::|.:|:..|:       |.....|..
Yeast   288 ---------KEKELH-------KEGTISKLENKENGLLNEISRLKTSLSIKVENLNDTTEKSKAL 336

  Fly   374 EDEIENES----QRRGKSVNMEEG--LVQE--------YDRLKQEAEATATQ-----------YR 413
            |.||.:.|    :::....|.|:.  :|||        |.| |:|..:|.|.           |.
Yeast   337 ESEIASSSAKLIEKKSAYANTEKDYKMVQEQLSKQRDLYKR-KEELVSTLTTGISSTGAADGGYN 400

  Fly   414 SELDSVNREQKSEQDTLDGETNRRASVEESFKK--LTLQ--REEAVKRRDKLMDHIKSSQAALEE 474
            ::|    .:.|:|.:.:.....:.:...|..||  ||::  .:||.|..:..:.|:|..|...
Yeast   401 AQL----AKAKTELNEVSLAIKKSSMKMELLKKELLTIEPKLKEATKDNELNVKHVKQCQETC-- 459

  Fly   475 QNRIKDELRR---DVGTSKEKIAE-KQRELEDVRDQLGDAKSDKHEDARRKK--KQEVVEL---F 530
                 |:||.   :.|....:|.: ||||     |:|   ||..::..:..:  |:.|..|   :
Yeast   460 -----DKLRARLVEYGFDPSRIKDLKQRE-----DKL---KSHYYQTCKNSEYLKRRVTNLEFNY 511

  Fly   531 KKQVP--------GVYDRMINMCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQML 587
            .|..|        ||..::..: ...:.||..|:....|..:..::|...:||   .|:|:...|
Yeast   512 TKPYPNFEASFVHGVVGQLFQI-DNDNIRYATALQTCAGGRLFNVVVQDSQTA---TQLLERGRL 572

  Fly   588 EVE-TFLPLDYLQVKPLKERLRNISD---PRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPE 648
            ... |.:|||.:..:|:..::.:::.   |..|.|..::::|: :.|.:|:.|..||:|:||.||
Yeast   573 RKRVTIIPLDKIYTRPISSQVLDLAKKIAPGKVELAINLIRFD-ESITKAMEFIFGNSLICEDPE 636

  Fly   649 DAMKVAYEIDRSRFDALALDGTFYQKSGLISGGSHDLARKAKRWDEKHMAQLKMQKERLQEELKE 713
            .|.|:.:. .:.|..::.|.|..|...|.:||||.:.: ::...|.:...|::.|.|.:|.:|..
Yeast   637 TAKKITFH-PKIRARSITLQGDVYDPEGTLSGGSRNTS-ESLLVDIQKYNQIQKQIETIQADLNH 699

  Fly   714 LVKKSRKQSELATVESQIKGLENRLKYSMVDLESSKKSISQYDNQLQQVQSQLDEFGPKILEIER 778
            :.::  .|::.|| ..:.|.:::.|..|:..|:.:|:::..  |...|:.::.:|....|.|.|.
Yeast   700 VTEE--LQTQYAT-SQKTKTIQSDLNLSLHKLDLAKRNLDA--NPSSQIIARNEEILRDIGECEN 759

  Fly   779 RMQNREEHIQEIKENMNNVEDKVYASFCRRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSIN 843
            .::.::..:::.:|.::.:|             |::::|:       .::..|..|.::::..:.
Yeast   760 EIKTKQMSLKKCQEEVSTIE-------------KDMKEYD-------SDKGSKLNELKKELKLLA 804

  Fly   844 SQLDFEKQKDTKKNVERWERSVQDEEDALEGLKLAEARYLKEIDEDK-------EKMEKFKQDKQ 901
            .:|:.::.:..:|            .|..:.|:|...:...|:|.:|       :.:|..|.:..
Yeast   805 KELEEQESESERK------------YDLFQNLELETEQLSSELDSNKTLLHNHLKSIESLKLENS 857

  Fly   902 AKKQAVDDMEEDISKARKDVANLAKEIHNVGSHLSAVESKIEAKKNERQNILLQAKTDCIVVPLL 966
            ..:..:..:|:|:...:.::....|.:.::...|:.:|:.|:.|::|:::..|:          |
Yeast   858 DLEGKIRGVEDDLVTVQTELNEEKKRLMDIDDELNELETLIKKKQDEKKSSELE----------L 912

  Fly   967 RGSLDDAVRQSDPDVPSTSAAMENIIEVDYSSLPREYTKLKDDSAFKK-----------THEMLQ 1020
            :..:.|..:..     |.:..||.|||    .|.:::..|:|....:.           |:....
Yeast   913 QKLVHDLNKYK-----SNTNNMEKIIE----DLRQKHEFLEDFDLVRNIVKQNEGIDLDTYRERS 968

  Fly  1021 KDLQSKLDVLERIQTPNMKALQKLDAVTEKVQSTNEEFENARKKAKRAKAAFERVKNERSSRFVA 1085
            |.|..|...|.:...||:  :..::.|.:|..:.....:...|...:.:....::...:....|.
Yeast   969 KQLNEKFQELRKKVNPNI--MNMIENVEKKEAALKTMIKTIEKDKMKIQETISKLNEYKRETLVK 1031

  Fly  1086 CCQHISDAIDGIYKKLARNEAAQAYIGPDNPEEPYLDGINYNCVAPGKRFQPMNNLSGGEKTIAA 1150
            ..:.::.....|:..|..|..|:  :.|...:: ...|:...........:.:..||||::::.|
Yeast  1032 TWEKVTLDFGNIFADLLPNSFAK--LVPCEGKD-VTQGLEVKVKLGNIWKESLIELSGGQRSLIA 1093

  Fly  1151 LALLFSTHSFHPAPFFVLDEIDAALDNTNIGKVASYIRDHTTNLQTIVISLKEEFYGHADALVGI 1215
            |:|:.:...|.|||.::|||:|||||.::...:...|:......|.||:||||..:.:|:.:...
Yeast  1094 LSLIMALLQFRPAPMYILDEVDAALDLSHTQNIGHLIKTRFKGSQFIVVSLKEGMFANANRVFRT 1158

  Fly  1216 TPGEGDCLVS 1225
            ...:|..:||
Yeast  1159 RFQDGTSVVS 1168

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	288/1299 (22%)
		ABC_SMC1_euk	27..>171	CDD:213242	52/169 (31%)
		SMC_hinge	535..653	CDD:214944	33/129 (26%)
		DUF4700	<697..>810	CDD:292399	21/112 (19%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	31/96 (32%)
SMC2	NP_116687.1	Smc	1..1169	CDD:224117	291/1310 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810