DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC1 and SMC1

DIOPT Version :9

Sequence 1:NP_651211.2 Gene:SMC1 / 42853 FlyBaseID:FBgn0040283 Length:1238 Species:Drosophila melanogaster
Sequence 2:NP_116647.1 Gene:SMC1 / 850540 SGDID:S000001886 Length:1225 Species:Saccharomyces cerevisiae


Alignment Length:1290 Identity:363/1290 - (28%)
Similarity:661/1290 - (51%) Gaps:153/1290 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 IEMENFKSYRGHIVVG-PLKQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIH---- 89
            :|:.|||||||...|| ....|.::||||||||||.|||||||:|.:::.||...|.|||:    
Yeast     7 LELSNFKSYRGVTKVGFGESNFTSIIGPNGSGKSNMMDAISFVLGVRSNHLRSNILKDLIYRGVL 71

  Fly    90 -----------GSSIGKPVSRSCYVTAKFVLNEERHMDFQRAVI-GGSSEYRINGESVSSSTYLN 142
                       |::...|  :|.||.| |.....:.::..|.:. .|.:.|:|:|::||...|..
Yeast    72 NDENSDDYDNEGAASSNP--QSAYVKA-FYQKGNKLVELMRIISRNGDTSYKIDGKTVSYKDYSI 133

  Fly   143 KLEKIGINVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQF 207
            .||...|.:||||||||||.||.||.::|.|.:.:|||:|||...|.:|..||:::....:....
Yeast   134 FLENENILIKAKNFLVFQGDVEQIAAQSPVELSRMFEEVSGSIQYKKEYEELKEKIEKLSKSATE 198

  Fly   208 TYQKKKGIAAERKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQEV 272
            :.:.::.|..|.|..|....:.:.|.:..::.||.|....|::|:|:|:...:.|..|.....|:
Yeast   199 SIKNRRRIHGELKTYKEGINKNEEYRKQLDKKNELQKFQALWQLYHLEQQKEELTDKLSALNSEI 263

  Fly   273 KAVEQRKEAADEILREKK----KDAGKITRDLAKIDQEIREFETQMNKRRPLYI---KAKEKVTH 330
            .:::.:.....:.|:..|    |::..|::..:|:|...::.|..::..|.:.:   .|.::::|
Yeast   264 SSLKGKINNEMKSLQRSKSSFVKESAVISKQKSKLDYIFKDKEKLVSDLRLIKVPQQAAGKRISH 328

  Fly   331 CKKKLISLQKTLETAREADNAHQSDIRKLEKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLV 395
            .:|::.||||.|:       ..::.:.:.|.||..|...|:.||:||: :|.|......:.|..:
Yeast   329 IEKRIESLQKDLQ-------RQKTYVERFETQLKVVTRSKEAFEEEIK-QSARNYDKFKLNENDL 385

  Fly   396 QEYDRLKQEAEATATQYRSELDSV--------NREQKSEQDTLDGETNRRASVEESFKKLTLQRE 452
            :.|:.|.:       :|.:|..|:        |.:::..|:.|: ..|:||.:  |.:::|   |
Yeast   386 KTYNCLHE-------KYLTEGGSILEEKIAVLNNDKREIQEELE-RFNKRADI--SKRRIT---E 437

  Fly   453 EAVKRRDKLMDHIKSSQAALEEQNRIKDE-------LRRDVGTSKEKIAEKQRELEDVRDQLGDA 510
            |.....:||...:...:.:|.|:|.:..|       |:.|:.::..:..:...:|.:...::.|.
Yeast   438 ELSITGEKLDTQLNDLRVSLNEKNALHTERLHELKKLQSDIESANNQEYDLNFKLRETLVKIDDL 502

  Fly   511 KSDKHEDARRKKKQEVVELFKKQVPGVYDRMINMCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTA 575
            .:::.|..:.:|.:|.:.:.|:..|||...:.::|.|..::|.:||:.:|||..:::||:....|
Yeast   503 SANQRETMKERKLRENIAMLKRFFPGVKGLVHDLCHPKKEKYGLAVSTILGKNFDSVIVENLTVA 567

  Fly   576 RHCIQILKEQMLEVETFLPLDYLQVKPLKERLRNIS--DPRNVRLVFDVLKFEPQEIERAVLFAT 638
            :.||..||:|.....:|:|||.::.:     |..:|  |.::..|..:.:.:|| |.|:|:.:..
Yeast   568 QECIAFLKKQRAGTASFIPLDTIETE-----LPTLSLPDSQDYILSINAIDYEP-EYEKAMQYVC 626

  Fly   639 GNALVCETPEDAMKVAYEIDRS---RFDALALDGTFYQKSGLISGGSHDLARKAKRWDEKHMAQL 700
            |::::|.|    :.:|.::...   |...:.::|....|:||::||....|.  .|||::....|
Yeast   627 GDSIICNT----LNIAKDLKWKKGIRGKLVTIEGALIHKAGLMTGGISGDAN--NRWDKEEYQSL 685

  Fly   701 KMQKERLQEELKELVKKSRKQSELA-TVESQIKGLENRLKYSMVDLESSKKSISQ------YDNQ 758
            ...|::|..::.||....|..|..| .||:.:..|.:.:......:...|:|:.:      |.|.
Yeast   686 MSLKDKLLIQIDELSNGQRSNSIRAREVENSVSLLNSDIANLRTQVTQQKRSLDENRLEIKYHND 750

  Fly   759 LQQVQSQLDEFGPKILEIERR---MQNREEHIQEIKENMNNVEDKVYASFCRRLGVKNIRQYEER 820
            |.:.:.|     |||.|::::   ::|.::::.:.||.:.|   .::..|..::|. .|::||..
Yeast   751 LIEKEIQ-----PKITELKKKLDDLENTKDNLVKEKEALQN---NIFKEFTSKIGF-TIKEYENH 806

  Fly   821 ELVMQQERARKRAEFEQQIDSINSQLDFEKQKDTKKNVERWERSVQDEEDA-LEGLKLAEARYLK 884
            ...:.::::::..:.::||.::.::|.||..: ......|:|::.:|.|:| :|...|.|..|..
Yeast   807 SGELMRQQSKELQQLQKQILTVENKLQFETDR-LSTTQRRYEKAQKDLENAQVEMKSLEEQEYAI 870

  Fly   885 E--IDEDKEKMEKFK------QDKQAKKQAVDDMEEDISKARKDVANLAKEIHNVGSHL------ 935
            |  |...:.|:|:.|      |.|...||:..:..|||             :.::.|:|      
Yeast   871 EMKIGSIESKLEEHKNHLDELQKKFVTKQSELNSSEDI-------------LEDMNSNLQVLKRE 922

  Fly   936 -SAVESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVRQSDPDVPSTSAAMENIIEVDYSSL 999
             ..::..||....||...|...|...|.:|:...:..|.:..|..|  :.:..:.|.|:::|..|
Yeast   923 RDGIKEDIEKFDLERVTALKNCKISNINIPISSETTIDDLPISSTD--NEAITISNSIDINYKGL 985

  Fly  1000 PREYTKLKDDSAFKKTHEMLQKDLQSKL----DVLERIQTPNMKALQKLDAVTEKVQSTNEEFEN 1060
            |::|.:...|||        :|:|:.|:    ::|..:| ||.:||::.|....:.:..|.|.|.
Yeast   986 PKKYKENNTDSA--------RKELEQKIHEVEEILNELQ-PNARALERYDEAEGRFEVINNETEQ 1041

  Fly  1061 ARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARN-------EAAQAYIGPDNPEE 1118
            .:.:.|:....|.::|.:|...|.....::||.:|.||::|.:|       ....|.:..::.:|
Yeast  1042 LKAEEKKILNQFLKIKKKRKELFEKTFDYVSDHLDAIYRELTKNPNSNVELAGGNASLTIEDEDE 1106

  Fly  1119 PYLDGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTNIGKV 1183
            |:..||.|:...|.|||:.|..|||||||:|||||||:.:|:.|:|||||||:|||||.||:.::
Yeast  1107 PFNAGIKYHATPPLKRFKDMEYLSGGEKTVAALALLFAINSYQPSPFFVLDEVDAALDITNVQRI 1171

  Fly  1184 ASYIRDH-TTNLQTIVISLKEEFYGHADALVGITPGEGDCLVSNVYIMDLTTFED 1237
            |:|||.| ..:||.||||||...:..:|||||:...:.: ..|.:..:||:.:.:
Yeast  1172 AAYIRRHRNPDLQFIVISLKNTMFEKSDALVGVYRQQQE-NSSKIITLDLSNYAE 1225

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC1NP_651211.2 Smc 26..1216 CDD:224117 360/1267 (28%)
ABC_SMC1_euk 27..>171 CDD:213242 67/157 (43%)
SMC_hinge 535..653 CDD:214944 35/119 (29%)
DUF4700 <697..>810 CDD:292399 26/122 (21%)
ABC_SMC1_euk <1130..1232 CDD:213242 54/102 (53%)
SMC1NP_116647.1 Smc 3..1225 CDD:224117 363/1290 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157346654
Domainoid 1 1.000 479 1.000 Domainoid score I59
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H4597
Inparanoid 1 1.050 479 1.000 Inparanoid score I222
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53603
OrthoFinder 1 1.000 - - FOG0001963
OrthoInspector 1 1.000 - - oto99909
orthoMCL 1 0.900 - - OOG6_101499
Panther 1 1.100 - - LDO PTHR18937
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1351
SonicParanoid 1 1.000 - - X1284
TreeFam 1 0.960 - -
1514.790

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