DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMC1 and SMC6

DIOPT Version :9

Sequence 1:NP_651211.2 Gene:SMC1 / 42853 FlyBaseID:FBgn0040283 Length:1238 Species:Drosophila melanogaster
Sequence 2:XP_011531409.1 Gene:SMC6 / 79677 HGNCID:20466 Length:1110 Species:Homo sapiens


Alignment Length:1325 Identity:265/1325 - (20%)
Similarity:468/1325 - (35%) Gaps:460/1325 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 EDDDVAQRVATAPVRKPDDETAFLEYIEMENFKSYRGHIVVGPLK---QFNAVIGPNGSGKSNFM 65
            ::|:......||.      |...:|.|.::||..   |.::||.|   ..|.|:|.||||||..:
Human    31 DEDECKGTTLTAA------EVGIIESIHLKNFMC---HSMLGPFKFGSNVNFVVGNNGSGKSAVL 86

  Fly    66 DAISFVMG------EKTSSLR--VK--------------RLNDLIHGSSIGKPVSRSCYVTAKFV 108
            .|:...:|      .:.|||:  ||              |.:|....|..|..:           
Human    87 TALIVGLGGRAVATNRGSSLKGFVKDGQNSADISITLRNRGDDAFKASVYGNSI----------- 140

  Fly   109 LNEERHMDFQRAVIGGSSEYRI---NGESVSSSTYLNKLEKIGI----NVKAKN---FLVFQGAV 163
                  :..|...|.||..|::   .|..||:    .|.|.|.|    |::..|   .|..:.:.
Human   141 ------LIQQHISIDGSRSYKLKSATGSVVST----RKEELIAILDHFNIQVDNPVSVLTQEMSK 195

  Fly   164 ENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQKKKGIAAERKEAKHEKME 228
            :.:..|...::...|.:.:....:|:||:.:.:    .:|.|              ||..|:..|
Human   196 QFLQSKNEGDKYKFFMKATQLEQMKEDYSYIME----TKERT--------------KEQIHQGEE 242

  Fly   229 ADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQE-----VKAVEQRKEAADEILRE 288
              |.|.|:.:..||:..:|..      ..:....::||..:.|     |..:|::..|.      
Human   243 --RLTELKRQCVEKEERFQSI------AGLSTMKTNLESLKHEMAWAVVNEIEKQLNAI------ 293

  Fly   289 KKKDAGKITRD-LAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKTLETAREADNAH 352
              :|..||..| .|::|:::.|.:.::|:              .::|...:|..||...|..||.
Human   294 --RDNIKIGEDRAARLDRKMEEQQVRLNE--------------AEQKYKDIQDKLEKISEETNAR 342

  Fly   353 QSDIRKLEKQLADVEALKKRFEDEIE---NESQRRGKSVNMEEGLVQEYDRLKQEAEATATQYRS 414
            ..:...|:   |||.| |||..:|.|   |.|             :.||..||::.|....:   
Human   343 APECMALK---ADVVA-KKRAYNEAEVLYNRS-------------LNEYKALKKDDEQLCKR--- 387

  Fly   415 ELDSVNREQKSEQDTLDGETNRRASVEESFKKLTLQREEAVK----RRDKLMDHIKSSQAALEEQ 475
                :...:||...:|:.|...|.      ||::..:|. ||    :.:.:...|:..|.|:|:.
Human   388 ----IEELKKSTDQSLEPERLERQ------KKISWLKER-VKAFQNQENSVNQEIEQFQQAIEKD 441

  Fly   476 NRIKDELRRDVGTSKEKIAEKQRELEDVRDQLGDAKSDKHEDARRKKKQEVVELFKKQVPGVYDR 540
            .....:::|:....|..::..||:|::::    |:|:|:            ::.|...||.:.:.
Human   442 KEEHGKIKREELDVKHALSYNQRQLKELK----DSKTDR------------LKRFGPNVPALLEA 490

  Fly   541 MINMCQPTHKRYN-----------------VAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLE 588
            :.:..:..|..|.                 :|:...|...::|.........| .:|.|.::...
Human   491 IDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADER-VLQALMKRFYL 554

  Fly   589 VETFLPLDYLQVKPLKERLRNISDPRNVRLVFDV---LKFEPQ--------EIERAVLFATGNAL 642
            ..|..|       |:     .:|:.||.  ::||   ..:.|.        ||:.||:   .|:|
Human   555 PGTSRP-------PI-----IVSEFRNE--IYDVRHRAAYHPDFPTVLTALEIDNAVV---ANSL 602

  Fly   643 V----------------------CETPEDAMKVAYEIDRSRFDALALDGTFYQKSGL-------- 677
            :                      .:.|....:.|:..|..:..|    |.:|.....        
Human   603 IDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFA----GRYYSSENTRPKFLSRD 663

  Fly   678 ----ISGGSHDLARK------------AKRWDEKHMAQLKMQKERLQEELKELVKKSRKQSELAT 726
                ||...:::..|            |...|.||..:|   .:|.|...|||..|.||..    
Human   664 VDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEEL---LKRCQLHYKELKMKIRKNI---- 721

  Fly   727 VESQIKGLENRLKYSMVDLESSKKSISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIK 791
              |:|:.|||..::..||       |:..:::.|:.:|              :|:..|||:::.|
Human   722 --SEIRELENIEEHQSVD-------IATLEDEAQENKS--------------KMKMVEEHMEQQK 763

  Fly   792 ENMNNVEDKVYASFCRRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSINSQLDF-EKQKDTK 855
            |||.::         :.|.::...:|:..:..:.|        ..:..|.:..:|:. :.:.|.:
Human   764 ENMEHL---------KSLKIEAENKYDAIKFKINQ--------LSELADPLKDELNLADSEVDNQ 811

  Fly   856 KNVER-WERSVQDEEDALEGLKLAEARYLKEID-EDKEKMEKFKQDKQAKKQAVDDMEEDISKAR 918
            |..:| :|...::..|.|...|       :|:| ::||..||..|.:|...:.::        ..
Human   812 KRGKRHYEEKQKEHLDTLNKKK-------RELDMKEKELEEKMSQARQICPERIE--------VE 861

  Fly   919 KDVANLAKEIHNVGSHLSAVESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVRQSDPDVPS 983
            |..:.|.|||:.       :..||:|                                       
Human   862 KSASILDKEINR-------LRQKIQA--------------------------------------- 880

  Fly   984 TSAAMENIIEVDYSSLPREYTKLKDDSAFKKTHEMLQKDLQSKLDVLERIQTPNMKALQKLDAVT 1048
                 |:....|...:.|:|.:.::          ...||.||:..|:       |.::.|..:.
Human   881 -----EHASHGDREEIMRQYQEARE----------TYLDLDSKVRTLK-------KFIKLLGEIM 923

  Fly  1049 EKVQSTNEEFENARKKAK-----------------RAKAAFERVKNERSSRFVACCQHISDAIDG 1096
            |....|.::|.:.|:|.|                 |.|..|:.:.::|                 
Human   924 EHRFKTYQQFRSFRQKNKPNLYYYINLFQMQCLTLRCKLYFDNLLSQR----------------- 971

  Fly  1097 IYKKLARNEAAQAYIGPDNPEEPYLDGINYN---CVAPGK----RFQPMNNLSGGEKTIAALALL 1154
                        ||.|..|     .|..|..   .|.||:    .|..|..|||||::.:.:..:
Human   972 ------------AYCGKMN-----FDHKNETLSISVQPGEGNKAAFNDMRALSGGERSFSTVCFI 1019

  Fly  1155 FSTHSFHPAPFFVLDEIDAALDNTN 1179
            .|..|...:||..|||.|..:|..|
Human  1020 LSLWSIAESPFRCLDEFDVYMDMVN 1044

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC1NP_651211.2 Smc 26..1216 CDD:224117 261/1303 (20%)
ABC_SMC1_euk 27..>171 CDD:213242 44/178 (25%)
SMC_hinge 535..653 CDD:214944 25/167 (15%)
DUF4700 <697..>810 CDD:292399 27/112 (24%)
ABC_SMC1_euk <1130..1232 CDD:213242 19/54 (35%)
SMC6XP_011531409.1 Smc 48..1088 CDD:224117 261/1302 (20%)
ABC_SMC6_euk 48..>204 CDD:213243 44/179 (25%)
Fib_alpha <662..742 CDD:285864 24/95 (25%)
DUF5098 701..>835 CDD:293628 39/187 (21%)
ABC_SMC6_euk <996..1094 CDD:213243 17/49 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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