DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC1 and Smc4

DIOPT Version :9

Sequence 1:NP_651211.2 Gene:SMC1 / 42853 FlyBaseID:FBgn0040283 Length:1238 Species:Drosophila melanogaster
Sequence 2:NP_598547.1 Gene:Smc4 / 70099 MGIID:1917349 Length:1286 Species:Mus musculus


Alignment Length:1355 Identity:328/1355 - (24%)
Similarity:600/1355 - (44%) Gaps:263/1355 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 EEDDDVAQRVATAPVRKPDDE----------------------------TAFLEYIEMENFKSYR 39
            |.:....:..:.||.:.|.:|                            ...:.:|..:|||||.
Mouse    30 EMEQPAGEAESAAPAKPPGEELDNRSLEEILNSIPPPPPPAMASEAGAPRLMITHIVNQNFKSYA 94

  Fly    40 GHIVVGPL-KQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIHGSSIGKPVSRSCYV 103
            |..|:||. |:|:.:||||||||||.:|::.||.|.:...:|.|:|:.|||.|...|.: :||.|
Mouse    95 GEKVLGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHKDI-QSCTV 158

  Fly   104 TAKF------------VLNEERHMDFQRAVIGGSSEYRINGESVSSSTYLNKLEKIGINVKAKNF 156
            ...|            ||........:.|....:|.|.|:|:..:.....|.|...||::....|
Mouse   159 EVHFQKIIDKEGDDYEVLPNSNFYVSRTAYRDSTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRF 223

  Fly   157 LVFQGAVENIAMKTPKERT-------ALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQKKKG 214
            |:.||.||.|||..||.:|       ...|:|.|.|.|.:....|.:.:.:..|.......:.|.
Mouse   224 LILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKM 288

  Fly   215 IAAERKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQEVKAVEQRK 279
            :..|:...:.||..|..:..|:||..:|:.....:.::.::..|.:.|:..|...::.|.:.::.
Mouse   289 VEKEKDALEGEKNIAIEFLTLENEMFKKKNHICQYYIYDLQNRIAEITTQKEKIHEDTKEITEKS 353

  Fly   280 EAADEILREKK---KDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKT 341
            ......::.|.   ||..|....:.|..::.:|..||::...   ::.:||:.|...|...|:|.
Mouse   354 NVLSNEMKAKNSAVKDVEKKLNKVTKFIEQNKEKFTQLDLED---VQVREKLKHATSKAKKLEKQ 415

  Fly   342 LETAREADNAHQSDIRKLEKQLADVEALKKRFEDEIENESQRRGKSVNM-----EEGLVQEYDRL 401
            |          |.|..|:| :|..|.|..|    .:.||:..|..|:..     |:.|.:..|.|
Mouse   416 L----------QKDKEKVE-ELKSVPAKSK----TVINETTTRNNSLEKEREKEEKKLKEVMDSL 465

  Fly   402 KQEAEATATQYRSELDSVNREQKSEQDTLDG------ETNRRASVEESFKKLTLQREE-AVKRRD 459
            |||.:           .:.:|::.::..|.|      |...:..|.:|...:.|.|.. ||.:..
Mouse   466 KQETQ-----------GLQKEKEIQEKELMGFNKSVNEARSKMEVAQSELDIYLSRHNTAVSQLS 519

  Fly   460 KLMDHIKSSQAALEEQNRIKDELRRDVGTSKEKIAEKQRELE--------------DVRDQLGDA 510
            |..:.:.::...|:|:.....::...:..:::::.||::||:              |:..::.:|
Mouse   520 KAKEALITASETLKERKAAIKDINTKLPQTQQELKEKEKELQKLTQEEINLKSLVHDLFQKVEEA 584

  Fly   511 KSDKHEDARRKKKQEVVELFKK--QVPGVYDRMINMCQPTHKRYNVAVTKVLGKFMEAIIVDTEK 573
            ||....:..|.|..:.:...||  ::||:|.|:.:: ....::|::|::... ..::.|:||:..
Mouse   585 KSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDL-GAIDEKYDIAISSCC-HALDYIVVDSID 647

  Fly   574 TARHCIQILKEQMLEVETFLPLDYLQVKPLKERLRNISDPRNVRLVFDVLKFEPQEIERAVLFAT 638
            ||:.|:..||:..:.:.||:.||.:.|  ..:::..|..|.|...:||::|.:.:||.:|..||.
Mouse   648 TAQECVNFLKKHNIGIATFIGLDKMTV--WAKKMSKIQTPENTPRLFDLVKVKNEEIRQAFYFAL 710

  Fly   639 GNALVCETPEDAMKVAYEIDRSRFDALALDGTFYQKSGLISGGSHDLAR---------------- 687
            .:.||....:.|.:|||:.|| |:..:.|.|...::||.:|||...:.|                
Mouse   711 RDTLVANNLDQATRVAYQRDR-RWRVVTLQGQIIEQSGTMSGGGSKVMRGRMGSSVIDEISVEEV 774

  Fly   688 -KAKRWDEKHMAQ-LKMQKERLQEELKELVKKSR-----KQSELATVESQIKGLENRLKYSMVDL 745
             |.:...|:|..| :::|::::|.|  |.|.|.|     .::.|....:.|:||..:.:|..|  
Mouse   775 NKMESQLERHSKQAMQIQEQKVQHE--EAVVKLRHSERDMRNTLEKFAASIQGLSEQEEYLCV-- 835

  Fly   746 ESSKKSISQYDNQLQQVQSQLDEFGPKILEIERRMQN-REEHIQEIKENMNNVED---KVYASFC 806
                        |::::::.:....|     :|:.|. .||::...|:..:.|.:   ||.|.. 
Mouse   836 ------------QIKELEANVLTTAP-----DRKQQKLLEENVSVFKKEYDAVAEKAGKVEAEI- 882

  Fly   807 RRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSINSQLDFEKQKDTKKNVERWERSVQDEEDA 871
            :||. ..|.....|:|..||.:          :|:||.|||......||..|             
Mouse   883 KRLH-NTIIDINNRKLKAQQNK----------LDTINKQLDECASAITKAQV------------- 923

  Fly   872 LEGLKLAEARYLKEIDEDKEKMEKFKQDKQAKKQAVDDMEEDISKARKDVANLAKEIHNVGSHLS 936
              .:|.|: |.||:..:...:.||          .:.|.|::|:..:.::.|:..:...|.::..
Mouse   924 --AIKTAD-RNLKKAQDSVCRTEK----------EIKDTEKEINDLKTELKNIEDKAEEVINNTK 975

  Fly   937 AVESKIEAKKNERQNILLQAKT----------DCIVVPLLRGSLDDAVRQSDPDVPSTSAAMENI 991
            ..|:.:...:.|.:|:|.:.|.          |.:.:.|....:|..:             .|:.
Mouse   976 TAETSLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHI-------------SEHN 1027

  Fly   992 IEVDYSSLPREYTKLK----DDSAFKKTHEMLQKDLQ---------SKLDVLE---RIQTPNMKA 1040
            .::.|  ..:|.:|:|    :|:..:....:.|::|:         :::.:||   |...||:.|
Mouse  1028 SKIKY--WQKEISKIKLHPVEDNPVETVAVLSQEELEAIKNPESITNEIALLEAQCREMKPNLGA 1090

  Fly  1041 L----QKLDAVTEKVQSTNEEFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKL 1101
            :    :|.|...::|    .|.:....:....:.|:|.::.:|.:.|:|....|::.:...|:.|
Mouse  1091 IAEYKKKEDLYLQRV----AELDKITSERDNFRQAYEDLRKQRLNEFMAGFYVITNKLKENYQML 1151

  Fly  1102 ARNEAAQAYIGPD------NPEEPYLDGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSF 1160
            .        :|.|      :..:|:.:||.::...|.|.::.:.||||||||:::|||:|:.|.:
Mouse  1152 T--------LGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHY 1208

  Fly  1161 HPAPFFVLDEIDAALDNTNIGKVASYIRDHTTNLQTIVISLKEEFYGHADALVGI 1215
            .|.|.:.:||||||||..|:..||.||.:.|.|.|.|:|||:...:..:|.|:||
Mouse  1209 KPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGI 1263

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC1NP_651211.2 Smc 26..1216 CDD:224117 323/1304 (25%)
ABC_SMC1_euk 27..>171 CDD:213242 58/156 (37%)
SMC_hinge 535..653 CDD:214944 33/117 (28%)
DUF4700 <697..>810 CDD:292399 26/122 (21%)
ABC_SMC1_euk <1130..1232 CDD:213242 41/86 (48%)
Smc4NP_598547.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..51 4/20 (20%)
SMC_N 81..1272 CDD:308206 323/1304 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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