DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC1 and Smc6

DIOPT Version :9

Sequence 1:NP_651211.2 Gene:SMC1 / 42853 FlyBaseID:FBgn0040283 Length:1238 Species:Drosophila melanogaster
Sequence 2:NP_079971.2 Gene:Smc6 / 67241 MGIID:1914491 Length:1097 Species:Mus musculus


Alignment Length:1232 Identity:248/1232 - (20%)
Similarity:468/1232 - (37%) Gaps:325/1232 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 ETAFLEYIEMENFKSYRGHIVVGPLK---QFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRL 84
            |...:|.|::.||..   |.::||.|   ..|.|:|.||||||..:.|:...:|.|..:..    
Mouse    50 EVGIIESIQLRNFMC---HSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGKAVATN---- 107

  Fly    85 NDLIHGSSIGKPVSRSCYVTAKFVLNEERHMDFQRAVIG-GSSEYRIN--GESV---------SS 137
                .|||:           ..||...:...|....:.. |...:|.|  |:|:         .|
Mouse   108 ----RGSSL-----------KGFVKAGQNSADISITLRNRGDDAFRANVYGDSIVVQQHISVDGS 157

  Fly   138 STYLNKLEKIGINVKAKNFLV-----FQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQE 197
            .:|..|.||..:....|..|:     |...|:|......:|.:..|.:....|   |.|....:.
Mouse   158 RSYKLKSEKGTVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEG---DKYKFFMKA 219

  Fly   198 MIVAEEETQFTYQKKKGIAAERKEAKHEKME--ADRYTRLQNEYNEKQVEYQLFRLFHVERDIRK 260
            ..:.:.:..::|      ..|.||...|::.  .:|.|.|:.:..||:..:|..      ..:..
Mouse   220 TQLEQMKEDYSY------IMETKERTKEQINQGEERLTELKRQCLEKEERFQNI------AGLST 272

  Fly   261 FTSDLEVRQQE-----VKAVEQRKEAADEILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPL 320
            ..::||..:.|     |..:|::..|..:.::..::.|       ||:|:::.|.:.::|     
Mouse   273 MKTNLEYLKHEMAWAVVNEIEKQLNAIRDNIKIGEERA-------AKLDRKMEEQQVRLN----- 325

  Fly   321 YIKAKEKVTHCKKKLISLQKTLETAREADNAHQSDIRKLEKQLADVEALKKRFEDE--IENESQR 383
                     ..:||...:|..||...|..||...:...|:   .||.|..:.|.|.  :.|.|  
Mouse   326 ---------DAEKKYKDIQDKLEKISEETNARAPECMALK---TDVIARTRAFNDAEVLYNRS-- 376

  Fly   384 RGKSVNMEEGLVQEYDRLKQEAEATATQYRSELDSVNREQKSEQDTLDGETNRRASVEESFKKLT 448
                       :.||..||::.|....:       :...:||...:|:.|...|.      |::.
Mouse   377 -----------LNEYKALKKDGEQLCKR-------IEELKKSTDQSLEPERLERQ------KRIC 417

  Fly   449 LQREEAVKRRDKLMDHIKSSQA-----ALEEQNRIKDELRRDVGTSKEKIAEKQRELEDVRDQLG 508
            ..:|:....:|:  :|..:.:|     |:|:..:....:|::....:..:...||:|::::    
Mouse   418 WLKEKVKALQDQ--EHTVNQEAEQFEQAIEKDKQEHGRVRKEDIEVRHALNYNQRQLKELK---- 476

  Fly   509 DAKSDKHEDARRKKKQEVVELFKKQVPGV---YDRMINMCQPTHKRYNVAVTKVLGKFMEAIIVD 570
            |:|:|:            ::.|...||.:   .|......|.|||...     .||.        
Mouse   477 DSKTDR------------LKRFGPHVPALLEAIDDAYRRRQFTHKPIG-----PLGA-------- 516

  Fly   571 TEKTARHCIQILKEQM-LEVETFLPLDYLQVKPLKER--LRNISDPRNVRLVFDVLKFEPQEIER 632
                   ||.:...:: |.:|:.|       |.|.:.  ..|.:|.|.::.:  :.||.|....|
Mouse   517 -------CIHLRDPELALAIESCL-------KGLLQAYCCHNHADERVLQSL--MKKFYPPGTSR 565

  Fly   633 AVLFATGNALVCETPEDA----MKVAYEID-RSRFDALALDGTFYQKSGLISGGSHDLARKAKRW 692
            ..:      :|.|..::.    ::.||..: .:...||.:|......| ||...|.:.....|  
Mouse   566 PQI------IVSEFRDEVYDVRLRAAYHPEFPTVLTALEIDNAVVANS-LIDMRSIETVLLIK-- 621

  Fly   693 DEKHMAQLKMQKERLQEELKEL-------VKKSRKQSELAT--------VESQIKGLENRLKYSM 742
             ...:|:..||.::..:..:|.       |...|..|..:|        |:|:|..||       
Mouse   622 -NNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSESTRPKFLSRDVDSEISDLE------- 678

  Fly   743 VDLESSKKSISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQ-EIKENMNNVEDKVYASFC 806
            .::|:.|..|.    .|||..|.|::...:..|:.:|.|...:.|: :|::|::.:.:       
Mouse   679 TEIENKKGHII----TLQQRLSALEKDIKRNEELLKRCQLHYKEIKMKIRKNISEIRE------- 732

  Fly   807 RRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSINSQLDFEKQKDTKKNVERWERSVQDEEDA 871
                ::||.:::..::...::.|.:.....|.::.     :.|:||:..:|::..:...:::.|.
Mouse   733 ----LENIEEHQSVDIATLEDEAEENKIKMQMVEK-----NMEQQKENMENLKSLKIEAENKYDT 788

  Fly   872 LEGLKLAEARYLKEIDEDKEKMEKFKQDKQAK-KQAVDDMEEDISKARKDVANLAKEIHNVGSHL 935
            :: ||:.:...|.:..:|:..:...:.|.|.: ||..:|.:::                    ||
Mouse   789 IK-LKINQLSELADPLKDELNLADSEVDSQKRGKQHYEDKQKE--------------------HL 832

  Fly   936 SAVESK---IEAKKNERQNILLQAKTDC---IVVPLLRGSLDDAVRQSDPDVPSTSAAMENIIEV 994
            ..:..|   ::.|:.|.|..:.||:..|   |.|......||..:.:....:.:     |:....
Mouse   833 DTLNKKRRELDMKEKELQEKMSQARQICPERIEVKKSASILDKEINRLRQKIQA-----EHASHG 892

  Fly   995 DYSSLPREYTKLKDDSAFKKTHEMLQKDLQSKLDVLERIQTPNMKALQKLDAVTEKVQSTNEEFE 1059
            |...:.::|.:.::          ...||.:|:..|.|.    :|.|:::  :|.:.: |.::|.
Mouse   893 DREEIMKQYQEARE----------TYLDLDNKVRTLRRF----IKLLEEI--MTHRYK-TYQQFR 940

  Fly  1060 NARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEAAQAYIGPDNPEEPYLDGI 1124
              |....|.|..|:.:.::|                             ||.|..|     .|..
Mouse   941 --RCLTLRCKLYFDNLLSQR-----------------------------AYCGKMN-----FDHK 969

  Fly  1125 NYN---CVAPGK----RFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTN 1179
            |..   .|.||:    .|..|..|||||::.:.:..:.|..|...:||..|||.|..:|..|
Mouse   970 NETLSITVQPGEGNKASFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVN 1031

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC1NP_651211.2 Smc 26..1216 CDD:224117 247/1229 (20%)
ABC_SMC1_euk 27..>171 CDD:213242 41/163 (25%)
SMC_hinge 535..653 CDD:214944 24/127 (19%)
DUF4700 <697..>810 CDD:292399 27/128 (21%)
ABC_SMC1_euk <1130..1232 CDD:213242 19/54 (35%)
Smc6NP_079971.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32
Smc 54..1075 CDD:224117 247/1228 (20%)
ABC_SMC6_euk 54..>210 CDD:213243 43/177 (24%)
Flexible hinge 458..667 50/263 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 813..839 7/45 (16%)
ABC_SMC6_euk <983..1081 CDD:213243 17/49 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1078..1097
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.