DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC1 and Smc1a

DIOPT Version :9

Sequence 1:	NP_651211.2	Gene:	SMC1 / 42853	FlyBaseID:	FBgn0040283	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_113871.2	Gene:	Smc1a / 63996	RGDID:	61991	Length:	1233	Species:	Rattus norvegicus

Alignment Length:	1229	Identity:	605/1229 - (49%)
Similarity:	868/1229 - (70%)	Gaps:	23/1229 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 FLEYIEMENFKSYRGHIVVGPLKQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIHG 90
            ||:.||:||||||:|..::||.::|.|:||||||||||.|||||||:|||||:||||.|.|||||
  Rat     3 FLKLIEIENFKSYKGRQIIGPFQRFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKTLRDLIHG 67

  Fly    91 SSIGKPVSRSCYVTAKFVLNEERHMD--FQRAVIGGSSEYRINGESVSSSTYLNKLEKIGINVKA 153
            :.:|||.:...:|:  .|.:||...|  |.|.::||||||:||.:.|....|..:|||:||.:||
  Rat    68 APVGKPAANRAFVS--MVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGILIKA 130

  Fly   154 KNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQKKKGIAAE 218
            :||||||||||:||||.||||||||||||.||.|..:|::.|:||:.|||:|||.|.:||.||||
  Rat   131 RNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAE 195

  Fly   219 RKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQEVKAVEQRKEAAD 283
            |||||.||.|||||.||::|....||:.|||:|:|.|.:|.|...:|..:.:|::..::|.:..:
  Rat   196 RKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVE 260

  Fly   284 EILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKTLETAREA 348
            :.|:||||:.||:.|:..:|::||:|.::::|::||.||||||..:|..|||.:.:|:|:.|::.
  Rat   261 DELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKH 325

  Fly   349 DNAHQSDIRKLEKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLVQEYDRLKQEAEATATQYR 413
            ....:.|:.:|||::..||..::.||:.:|.|||.:|:.:.:||..|::|.|||:||...|....
  Rat   326 YKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLA 390

  Fly   414 SELDSVNREQKSEQDTLDGETNRRASVEESFKKLTLQREEAVKRRDKLMDHIKSSQAALEEQNRI 478
            .||:..||:||::||.||.|..::...|...|:...:.||..||.:||.::|.:|:.:||||.::
  Rat   391 QELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKL 455

  Fly   479 KDELRRDVGTSKEKIAEKQRELEDVRDQLGDAKSDKHEDARRKKKQEVVELFKKQVPG-VYDRMI 542
            :.||..:|..:|.:|.|..:||..|.:|||||:.|:.|.:|:::|.|::|..|:..|| ||.|:|
  Rat   456 EGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLI 520

  Fly   543 NMCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPLKERL 607
            ::||||.|:|.:||||||||.|:|||||:|||.|.|||.:|||..|.|||||||||:|||..|:|
  Rat   521 DLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKL 585

  Fly   608 RNISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALALDGTFY 672
            |.:   :..:||.||:::||..|::|:.:|.||||||:..|||.::|:. ...|...:|||||.:
  Rat   586 REL---KGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFG-GHQRHKTVALDGTLF 646

  Fly   673 QKSGLISGGSHDLARKAKRWDEKHMAQLKMQKERLQEELKELVKKSRKQSELATVESQIKGLENR 737
            ||||:||||:.||..||:|||||.:.:||.:||||.|||||.:|..||::||..|:||..||:.|
  Rat   647 QKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMR 711

  Fly   738 LKYSMVDLESSK-KSISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIKENMNNVEDKV 801
            ||||..|||.:| :.::....:..:::|:|..|||:|.:|:|.:|:||..::::||.||.|||:|
  Rat   712 LKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEV 776

  Fly   802 YASFCRRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSINSQLDFEKQ--KDTKKNVERWERS 864
            :..|||.:||:|||::||.::..|.|.|:||.|||.|...:..||||||.  |:.:..|..||::
  Rat   777 FEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQT 841

  Fly   865 VQDEEDALEGLKLAEARYLKEIDEDKEKMEKFKQDKQAKKQAVDDMEEDISKARKDVANLAKEIH 929
            |:.:|:.:|.||..|.|::|.|||...:::..|....|||..|:|...::.:.||.:....||:.
  Rat   842 VKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMT 906

  Fly   930 NVGSHLSAVESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVRQ----------SDPDVPST 984
            ::...::|:|:|:|.|:::|.|:|...|...|.:||.:|::||..::          |.....|:
  Rat   907 HLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGGSQGEESVSGSQRTSS 971

  Fly   985 SAAMENIIEVDYSSLPREYTKLKDDSAFKKTHEMLQKDLQSKLDVLERIQTPNMKALQKLDAVTE 1049
            ..|.|.:||:||..|..:....:.:...|:....||:.|..:..||:||..|||||::||::|.:
  Rat   972 IYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRD 1036

  Fly  1050 KVQSTNEEFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEAAQAYIGPD 1114
            |.|.|::|||.|||:||:||.|||::|.||..||.||.:.::..||.|||.|:||.:|||::||:
  Rat  1037 KFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKALSRNSSAQAFLGPE 1101

  Fly  1115 NPEEPYLDGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTN 1179
            |||||||||||||||||||||:||:||||||||:|||||||:.||:.||||||||||||||||||
  Rat  1102 NPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTN 1166

  Fly  1180 IGKVASYIRDHTT-NLQTIVISLKEEFYGHADALVGITPGEGDCLVSNVYIMDLTTFED 1237
            |||||:||::.:| |.|.||||||||||..|::|:|:.|.:|||::|.|...|||.:.|
  Rat  1167 IGKVANYIKEQSTCNFQAIVISLKEEFYTKAESLIGVYPEQGDCVISKVLTFDLTKYPD 1225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	595/1206 (49%)
		ABC_SMC1_euk	27..>171	CDD:213242	87/145 (60%)
		SMC_hinge	535..653	CDD:214944	70/118 (59%)
		DUF4700	<697..>810	CDD:292399	52/113 (46%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	72/102 (71%)
Smc1a	NP_113871.2	SMC_N	3..1210	CDD:308206	597/1212 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..307		11/22 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..369		7/18 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	946..969		3/22 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1149	1.000	Domainoid score	I16
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4597
Inparanoid	1	1.050	1173	1.000	Inparanoid score	I189
OMA	1	1.010	-	-		QHG53603
OrthoDB	1	1.010	-	-		D326079at2759
OrthoFinder	1	1.000	-	-		FOG0001963
OrthoInspector	1	1.000	-	-		otm45837
orthoMCL	1	0.900	-	-		OOG6_101499
Panther	1	1.100	-	-	LDO	PTHR18937
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1284
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840