Protein Alignment SMC1 and smc5

DIOPT Version :9

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_001180470.1
• Gene: smc5 / 566749
• ZFINID: ZDB-GENE-061013-288
• Length: 1073
• Species: Danio rerio
• Alignment Length: 1256
• Identity: 256/1256 - (20%)
• Similarity: 470/1256 - (37%)
• Gaps: 362/1256 - (28%)

  Fly    14 TAPVRKPDDETAFLEYIEMENFKSYRGHIVVGPLKQFNAVIGPNGSGKSNFMDAISFVMGEKTSS 78
            :|..|:.|.....:..|.|.||.:| .|..|.|..:.|.::|.||:|||:.:.||...:..|||.
Zfish    29 SANAREGDFMEGAIVRITMHNFLTY-DHSEVFPGPKLNMIVGANGTGKSSIVCAICLGLAGKTSV 92

  Fly    79 LRVKRLNDLIHGSSIGKPVSRSCYVTAKFVLNEERHMDFQRAVIGGSSE---YRINGESV----- 135
            |.        .|..:|..|.|.|                ||    ||.|   ||..|..:
Zfish    93 LG--------RGDKVGLYVKRGC----------------QR----GSVEIELYRTRGNLIVTREI 129

  Fly   136 ----SSSTYLNKLEKIGINVKAKNFLVFQGAVE--NIAMKTPKERTALFEEISGSGLLKDDYNRL 194
                :.||::  |.|...:.||....|.:..::  |:....|:|:...|.::|.|.||:     .
Zfish   130 QVENNQSTWM--LNKKHASQKAVEEAVRELHIQVGNLCQFLPQEKVGEFAKMSNSELLE-----A 187

  Fly   195 KQEMIVAEEETQFTYQKKKGIAAER--KEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVER- 256
            .::.:...|..:|..:.|.....||  :....||.......|.:||.|:..||....:..|::|
Zfish   188 TEKSVGPPEMYEFHCELKTFRTKERDLENVCKEKGNFLEKARQRNERNKLDVERYYMKKRHLDRI 252

  Fly   257 ---DIRKFTSDLEVRQQEVKAVEQRKEAADEILREKKKDAGKITRDLAKIDQEIREFETQMNKRR 318
               :.:|...:.|..::|::.|::.::.....||..|:....:.|.:..::.|::..|.||   :
Zfish   253 QMLEKKKPWVEYETARKELEGVKKERDEMKRKLRFLKEAQEPLLRKIRSVESELQPIEQQM---K 314

  Fly   319 PLYIKAKEKVTHCKKKL----------------ISLQKTLETAREADNAH-QSDIRKLEKQLADV 366
            .:..:.||....||:|.                :||::|.|..|:....| |..||.|:|:|.::
Zfish   315 EMTNRIKEATQKCKQKHDQLELKNKEVDDIKQDMSLKQTEEADRQKRIGHTQLMIRDLQKELQNM 379

  Fly   367 EALKKRFED---EIENESQRRGKSVNMEEGLVQEYDRLKQEAEATATQYRSELDSVNREQKSEQD 428
            ..:    ||   :||        ::|.|...:||              .|:.|:|.:.:.:.::|
Zfish   380 GTI----EDVTPQIE--------AINAELRNIQE--------------ERARLESESLDLRRDKD 418

  Fly   429 TLDGE----TNRRASVEESFKKLTLQREEAVKRRDKLMDHIKSSQAALEEQNRIKDELRRDVGTS 489
            .:.||    .||..|:::..|          .:.:||....:.:..|||       .||::....
Zfish   419 EITGEFARLQNRLRSLDDMMK----------IKEEKLRSRFRDTYTALE-------WLRKNRDRY 466

  Fly   490 KEKIAEKQRELEDVRDQLGDAKSDKHEDARRKKKQEVVELFKKQVPGVYDRMINMCQPTHK-RYN 553
            :..:.|....:.:||    ||:..|:.:...........:|::|...  |:.:|..:.|.: |.|
Zfish   467 EGVVHEPMMLVINVR----DARHAKYIETHISVNDLRAFVFQRQDDN--DKFMNEMRDTQRLRVN 525

  Fly   554 VAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPLKERLRNISDPRNVRL 618
                        :||..||..::      :.....:||..|..::..               :|.
Zfish   526 ------------SIIAPTESCSK------RPPSRPIETLKPYGFISY---------------LRE 557

  Fly   619 VFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALALDGTFYQKSGLISGGSH 683
            :||                        .||:.|  :|...:.|.:.:.: ||
Zfish   558 MFD------------------------APEEVM--SYLCHQYRVNDVPI-GT------------- 582

  Fly   684 DLARKAKRWDEKHMAQLKMQKERLQEELKELVKKSRKQSELATVESQIKGLENRLKYSMVDLESS 748
                                     |:.|.:            :||.||.|:.|..|:..:..:.
Zfish   583 -------------------------EKTKGM------------IESVIKDLQLRTIYTAEERYNV 610

  Fly   749 KKSISQYDNQLQQVQSQL--DEFGPKILEIERRMQNREEHIQEIKENMNNVEDKVYASFCRRLGV 811
            ||  |.|.|.:....|.|  .:|....:::|.|.|..|:
Zfish   611 KK--SAYSNNVVSSNSALRPPQFLTTTIDVEERRQLEEQ-------------------------- 647

  Fly   812 KNIRQYEERELVMQQERARKRAEFEQQ--IDSINSQLDFEKQK--DTKKNVERWERSVQDEEDAL 872
              :|..|.::..:.|..|..|   |||  :|..:::|...|:|  |.|....:.|:.:..::|:
Zfish   648 --LRAAERQKQSIDQRMAAIR---EQQANLDRRDNELRANKKKLSDLKSKKRQLEQKISTKQDS- 706

  Fly   873 EGLKLAEARYLKEIDEDKEKMEKFKQDKQAKKQAVDDMEEDISKARKDVANLAKEIHNVGSHLSA 937
                      |:::::::..:...:::..||..||::                |::..:|.:||.
Zfish   707 ----------LRQMEQNEINLVAIEEEANAKIAAVNN----------------KKVTIMGEYLSH 745

  Fly   938 VESKIEAKKN-ERQNILLQAKTDCIVVPLLRGSLDDAVRQSDPDVPSTSAAMENIIEVDYSSLPR 1001
            ::||  |:.| |:..:.||:           ..|.....:.:.||..:||.::. .||||:.|.:
Zfish   746 LQSK--ARLNMEKVYLALQS-----------AGLSAEKTKLETDVRESSAELKR-AEVDYTKLDK 796

  Fly  1002 EYTKL--KDDSAFKKTHEM---------LQKDLQSKLDVL-------------ERIQTPNMKALQ 1042
            ..|.|  ...:..|:..|:         :.::|.:...:|             ||.:......|.
Zfish   797 IKTNLLMTCKTLMKRASEICNMTPGETAVPEELHAAFSLLPETLDEIDAMLNEERTRAECFTGLS 861

  Fly  1043 KLDAVTEKVQSTNEEFENARKK---AKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARN 1104
              |||.::.....:|.:|..|:   .......:.|...|...|::...:.:.:.|:..:....::
Zfish   862 --DAVVDEYNRREQEIKNLEKELDDKTNELTTYRRNIAEAKERWLNPLKKLVELINVRFSDFFQS 924

  Fly  1105 E--AAQAYIGPDNPEEPYLDGINYNCVAPGKRFQPMNNL-----SGGEKTIAALALLFSTHSFHP 1162
            .  |.:..:..:|.||  .|..........:|...|:.|     ||||:::..:..|.|....:.
Zfish   925 MQCAGEVDLHSENEEE--YDKYGIRIQVQFRRNTRMHELTPHHQSGGERSVTTMLYLMSLQELNR 987

  Fly  1163 APFFVLDEIDAALDNTNIGKV 1183
            .||.|:|||:..:|..|..:|
Zfish   988 CPFRVVDEINQGMDPVNERRV 1008

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	253/1244 (20%)
		ABC_SMC1_euk	27..>171	CDD:213242	42/157 (27%)
		SMC_hinge	535..653	CDD:214944	18/118 (15%)
		DUF4700	<697..>810	CDD:292399	21/114 (18%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	18/59 (31%)
smc5	NP_001180470.1	ABC_SMC5_euk	40..>185	CDD:213244	47/175 (27%)
		Smc	42..1030	CDD:224117	253/1243 (20%)
		ABC_SMC5_euk	<950..1052	CDD:213244	18/59 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810