Protein Alignment SMC1 and smc1al

DIOPT Version :10

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_997975.2
• Gene: smc1al / 403060
• ZFINID: ZDB-GENE-040426-57
• Length: 1233
• Species: Danio rerio
• Alignment Length: 1228
• Identity: 599/1228 - (48%)
• Similarity: 856/1228 - (69%)
• Gaps: 20/1228 - (1%)

  Fly    26 FLEYIEMENFKSYRGHIVVGPLKQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIHG 90
            :|:.||:||||||:|..::||..:|.|:||||||||||.|||||||:.||||:||||.|.|||||
Zfish     3 YLKLIEIENFKSYKGRQIIGPFHKFTAIIGPNGSGKSNLMDAISFVLAEKTSNLRVKTLKDLIHG 67

  Fly    91 SSIGKPVSRSCYVTAKFVLNEERHMDFQRAVIGGSSEYRINGESVSSSTYLNKLEKIGINVKAKN 155
            :.:|||.:...:||..:..:..:.:.|.|.:||.|||||||.:.|..|.|..:|||:||.:||:|
Zfish    68 APVGKPAANRAFVTMVYQQDGGQELSFSRIIIGSSSEYRINNKVVGLSDYSEELEKLGILIKARN 132

  Fly   156 FLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQKKKGIAAERK 220
            |||||||||:||||.||||||||||||.||.|..:|:|.|:||:.|||:|||.|.:||.||||||
Zfish   133 FLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDRCKKEMVKAEEDTQFNYHRKKNIAAERK 197

  Fly   221 EAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQEVKAVEQRKEAADEI 285
            |||.||.||:||.||::|.....|:.|||:|:|.|.:|.|...:|..|.:|:....:|.:..:|.
Zfish   198 EAKQEKEEAERYQRLKDEVVRAHVQLQLFKLYHNESEIEKLNRELAHRNKEIDKDRKRMDRVEEE 262

  Fly   286 LREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKTLETAREADN 350
            |::|||:.|::.||...|::||:|.:.::|::|||||||||...|..|||.:.:|:|:.|::...
Zfish   263 LKDKKKELGRMMRDQQMIEKEIKEKDAELNQKRPLYIKAKENTAHKIKKLEAARKSLQNAQKCYK 327

  Fly   351 AHQSDIRKLEKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLVQEYDRLKQEAEATATQYRSE 415
            ..:.|:.:|:::...||..::.||:.:|.|:|.:|:.:.:||..|:.|.|||:||...|.....|
Zfish   328 KRKGDMDELDREQGAVEMARQEFEERMEEEAQSQGQDLQLEENQVKAYHRLKEEASKRAATLAQE 392

  Fly   416 LDSVNREQKSEQDTLDGETNRRASVEESFKKLTLQREEAVKRRDKLMDHIKSSQAALEEQNRIKD 480
            |:..||:||::||.||.|..::...|...|:...:.||..||.:||.|:|.:|:.:|:||.|:::
Zfish   393 LEKFNRDQKADQDRLDLEERKKIETEAKIKQKIREIEENQKRIEKLEDYITTSRQSLDEQKRMEE 457

  Fly   481 ELRRDVGTSKEKIAEKQRELEDVRDQLGDAKSDKHEDARRKKKQEVVELFKKQVPG-VYDRMINM 544
            ||..:|..:|.:|.|...||..|.:|||||:.|:.|::|:::|.|::|..|:..|| ||.|:|::
Zfish   458 ELTEEVEQAKRRIDEINMELNQVMEQLGDARIDRQENSRQQRKAEILESIKRLYPGSVYGRLIDL 522

  Fly   545 CQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPLKERLRN 609
            ||||.|:|.:||||||||.|:|||||:|||.|.|||.:|||..|.|||||||||:|||..|:||.
Zfish   523 CQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRE 587

  Fly   610 ISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALALDGTFYQK 674
            :   |..:||.||:::||.:|::|:.:|.||||||:..|||.::|:. ...|...:|||||.:||
Zfish   588 L---RGAKLVIDVIRYEPPQIKKALQYACGNALVCDNVEDARRIAFG-GPYRHKTVALDGTLFQK 648

  Fly   675 SGLISGGSHDLARKAKRWDEKHMAQLKMQKERLQEELKELVKKSRKQSELATVESQIKGLENRLK 739
            ||:||||:.||..||:|||||.:.:||.:||:|.:||||.:|..||::||..|:||..||:.|||
Zfish   649 SGVISGGASDLKAKARRWDEKAVDKLKDRKEKLTDELKEQMKAKRKEAELRQVQSQAHGLQMRLK 713

  Fly   740 YSMVDLESSK-KSISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIKENMNNVEDKVYA 803
            ||..|||.:| :.:|....:..:::|:|..|||:|.:|:|.:|:||..::::|:.||.|||:|:.
Zfish   714 YSQSDLEQTKTRHLSLNMQEKSKLESELANFGPRINDIKRIIQSRERDMKDLKDRMNVVEDEVFV 778

  Fly   804 SFCRRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSINSQLDFEKQ--KDTKKNVERWERSVQ 866
            .||:.:||:|||::||.::..|.|.|:||.|||.|...:..|||:||.  |:.::.|..||::|:
Zfish   779 EFCKEIGVRNIREFEEEKVKRQNEIAKKRLEFETQKTRLAIQLDYEKNQLKEDQEKVVMWEQTVK 843

  Fly   867 DEEDALEGLKLAEARYLKEIDEDKEKMEKFKQDKQAKKQAVDDMEEDISKARKDVANLAKEIHNV 931
            .:|:.:|.||..|.|.:|.|||...:::..|.....||..|:|...::.:.||.:....||:..:
Zfish   844 KDENEIEKLKKEEQRNMKIIDETMAQLQDLKNQHLTKKSEVNDKNHEMEEIRKKLGGANKELTQL 908

  Fly   932 GSHLSAVESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVRQ-----------SDPDVPSTS 985
            ...::|:|:|:|.|:::|.|:|...|...|.:||..|::||..::           |.....||.
Zfish   909 QKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLRSGTMDDISQEEGNSQAEESLSSSQKTSSTV 973

  Fly   986 AAMENIIEVDYSSLPREYTKLKDDSAFKKTHEMLQKDLQSKLDVLERIQTPNMKALQKLDAVTEK 1050
            .|.|.:||:||:||..:......|...|.....||:.|..:..:|:||..|||||::||::|.:|
Zfish   974 LAKEALIEIDYNSLSEDLKDSLSDEEIKAEMNTLQQRLNEQQSILQRISAPNMKAMEKLESVRDK 1038

  Fly  1051 VQSTNEEFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEAAQAYIGPDN 1115
            .|.|::|||.|||:||:||.|||::|.||..||.||.:.::..||.|||.|:||.:|||::||:|
Zfish  1039 FQETSDEFEAARKRAKKAKQAFEQIKKERFDRFHACFESVATNIDEIYKALSRNSSAQAFLGPEN 1103

  Fly  1116 PEEPYLDGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTNI 1180
            ||||||||||||||||||||:||:||||||||:|||||||:.||:.|||||||||||||||||||
Zfish  1104 PEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNI 1168

  Fly  1181 GKVASYIRDHTT-NLQTIVISLKEEFYGHADALVGITPGEGDCLVSNVYIMDLTTFED 1237
            ||||:||:|.:. |.|.||||||||||..||:|:|:.|.:|||::|.|...||:.:.|
Zfish  1169 GKVANYIKDQSVQNFQAIVISLKEEFYTKADSLIGVYPEQGDCVISKVLTFDLSQYAD 1226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	SMC_N	26..1222	CDD:481474	592/1211 (49%)
smc1al	NP_997975.2	SMC_N	3..1211	CDD:426784	592/1211 (49%)