Protein Alignment SMC1 and SMC2

DIOPT Version :9

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Alignment Length: 1305
• Identity: 301/1305 - (23%)
• Similarity: 560/1305 - (42%)
• Gaps: 226/1305 - (17%)

  Fly    26 FLEYIEMENFKSY-RGHIVVGPLKQFNAVIGPNGSGKSNFMDAISFVMG-EKTSSLRVKRLNDLI 88
            :::.:.::.|||| |...:.|...:|.|:.|.|||||||.:|:|.||:| ....::|...|.||:
  Fly     2 YVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLV 66

  Fly    89 HGSSIGKPVSRSCYVTAKF----------VLNEERHMDFQR-AVIGGSSEYRINGESVSSSTYLN 142
            :.:  |:.......||..|          ...:.|.:...| .|:||.:::.|||:.|.:....:
  Fly    67 YKN--GQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQD 129

  Fly   143 KLEKIGINVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQF 207
            ....|.:||...|||:.||.::.:....|||..::.||.:|:...|           ...:.|:.
  Fly   130 FFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYK-----------TKRDATKT 183

  Fly   208 TYQKKKGIAAERKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERD----IRKFTSDLEVR 268
            ..:||:....|.|....|:: ..:..:|:.|.:..| |||     .:.||    ||...|...::
  Fly   184 LIEKKETKVRETKVLLDEEV-LPKLVKLRQERSAYQ-EYQ-----KICRDIDFLIRIHISAKYLK 241

  Fly   269 QQE-VKAVEQRKEAADEILREKKKDAGKITRDLAKIDQEIRE---------------FETQMNKR 317
            |.| :|.||..:...::.:...|....|...::..|:..::|               .|||::.:
  Fly   242 QCETLKTVEANEHKIEDRIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAK 306

  Fly   318 RPL------YIKAKE-KVTHCKKKLISLQKTLETAREADNAHQSDIRKLEKQLADVEALK----- 370
            |.|      .:||.: .:...:||:....|.:|....|....::|:.|::   .:.|:||
  Fly   307 RALEATATGSLKAAQGTIQQDEKKIRMASKNIEDDERALAKKEADMAKVQ---GEFESLKEADAR 368

  Fly   371 --KRFED---EIENESQRRGKSVNMEEGLVQEYDRLKQE--AEATATQYRSELDSVNREQKSEQD 428
              |.:||   ::|..||....:.|.|...:||...:.:|  :||..|...||::..:.....:|.
  Fly   369 DSKAYEDAQKKLEAVSQGLSTNENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQR 433

  Fly   429 TLDGETNRRASVEESFKKLTLQREEAVKRRDKLMDHIKSSQAALEEQNRIKDELRRDVGTSKEKI 493
            ..:.:||..|.|::  |||          .|:|:..||:    ||.|.:..|.    .|...||:
  Fly   434 EGETQTNDAAYVKD--KKL----------HDQLVVEIKN----LERQLQSLDY----EGGHFEKL 478

  Fly   494 AEKQREL----EDVRDQLGDAKSDKHE----------DARRKKKQEVVELFKKQVPGVYDRMINM 544
            .:::.:|    .|::.:|....:.:::          | |||.:..|.:||  ||..:.:.|
  Fly   479 KQRRNDLHMRKRDLKRELDRCNASRYDLQYQDPEPNFD-RRKVRGLVGKLF--QVKDMQNSM--- 537

  Fly   545 CQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPLK----E 605
                      |:.:..|..:.:.:.|.:.|::..:|  :..:....|.:|::.:|...|.    |
  Fly   538 ----------ALVQTAGGSLYSYVTDDDVTSKKILQ--RGNLQRRVTLIPINKIQSGSLNRNVVE 590

  Fly   606 RLRNISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALALDGT 670
            ..:|.....||:....::.:: :..|..:.|..|..|:|:....|.:::|: .|....::.|:|.
  Fly   591 YAQNKVGAENVQWAMSLIDYD-RYYEPVMKFCFGGTLICKDLIVAKQISYD-PRINCRSVTLEGD 653

  Fly   671 FYQKSGLISGGSHDLARKAKRWDEKHMAQLKMQKERLQEELKELVKKSRKQSELATVESQIKGLE 735
            .....|.:|||:  ..:.|...:|.|..      :::::|.:|:      .||:|.||.||..:|
  Fly   654 VVDPHGTVSGGA--APKGANVLEELHAI------KQIEKEYREI------DSEIAQVEKQIASIE 704

  Fly   736 NR-LKYSMV--DLESSKKSISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIKENMNNV 797
            |: |.::.:  :|:..:..::..:|:|.|...|.::  .:|.|:..|::..|:.|.:.:|.....
  Fly   705 NQALAFNKMKENLDLRQHELTMCENRLAQTTFQQNQ--AEIEEMRERVKTLEQQIIDSREKQKTS 767

  Fly   798 EDKVYASFCRRLGVKNIRQYEEREL--------VMQQERARKRAEF---EQQIDSINSQLDFEKQ 851
            :.|:.....:....|.   |.||||        |.:|...:.||.:   ||:.:::..::
  Fly   768 QAKIVDIEAKLADAKG---YRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLEI----- 824

  Fly   852 KDTKKNVERWERSVQDEEDALEGLKLAEARYLKEIDEDKEKMEKFKQDKQAKKQAVDDMEEDISK 916
            .:.:|::|..::..|:..|.||       ::..|:|..|........:....:||:.:.::.:..
  Fly   825 TELQKSIETAKKQHQEMIDNLE-------KFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRD 882

  Fly   917 ARKDVANLAKEIHNVGSHLSAVESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVRQSDPDV 981
            ..|::.|...:...:......:|.:::.|:||::.|...||
  Fly   883 QNKEMRNQLVKKEKMLKENQEIELEVKKKENEQKKISSDAK------------------------ 923

  Fly   982 PSTSAAMENIIEVDYSSLPRE----------YTKLKDDSAFKKTHEMLQK--DLQSKLDVLERIQ 1034
             .....|| .:|..|..:|.|          |...|:|     .||...|  .:|.|.|.:||
  Fly   924 -EAKKRME-ALEAKYPWIPEEKNCFGMKNTRYDYSKED-----PHEAGNKLAKMQEKKDKMER-- 979

  Fly  1035 TPNMKALQKLDAVTEKVQSTNEEFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYK 1099
            |.||.|:..||...|..:.|...........::.|....::..|...:.......::....||:.
  Fly   980 TLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEEEQDQLNKAATEVNTNFSGIFS 1044

  Fly  1100 KLARNEAAQAYIGPDNPEEPYLDGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAP 1164
            .|.  ..|:|.:.|.: ....|.|:.......|...:.:..||||:|::.||:|:.:...|.|||
  Fly  1045 SLL--PGAEAKLNPVH-TNGCLTGLEIKVGFNGIWKESLGELSGGQKSLVALSLVLAMLKFSPAP 1106

  Fly  1165 FFVLDEIDAALDNTNIGKVASYIRDHTTNLQTIVISLKEEFYGHADALVGITPGEGDCLVSNVYI 1229
            .::|||:|||||.::...:.|.::.|.||.|.:::|||:..:.||:.|......||...::....
  Fly  1107 LYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLFNHANVLFRTLFEEGVSTITRQVS 1171

  Fly  1230 MDLTT 1234
            ...||
  Fly  1172 RQATT 1176

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	297/1285 (23%)
		ABC_SMC1_euk	27..>171	CDD:213242	46/156 (29%)
		SMC_hinge	535..653	CDD:214944	20/121 (17%)
		DUF4700	<697..>810	CDD:292399	24/115 (21%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	34/101 (34%)
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	299/1295 (23%)
		ABC_SMC2_euk	1..>170	CDD:213240	51/169 (30%)
		SMC_hinge	520..637	CDD:214944	25/134 (19%)
		V_Alix_like	690..933	CDD:187408	56/285 (20%)
		P-loop_NTPase	<1073..1167	CDD:304359	34/93 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464471
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740