Protein Alignment SMC1 and Smc2

DIOPT Version :9

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_001102136.2
• Gene: Smc2 / 362519
• RGDID: 1305227
• Length: 1191
• Species: Rattus norvegicus
• Alignment Length: 1290
• Identity: 316/1290 - (24%)
• Similarity: 591/1290 - (45%)
• Gaps: 238/1290 - (18%)

  Fly    26 FLEYIEMENFKSYRGHIVVG---PLKQFNAVIGPNGSGKSNFMDAISFVMG-EKTSSLRVKRLND 86
            :::.|.:|.||||.....|.   ||  |||:.|.|||||||.:|:|.|::| ...|.:|...|.|
  Rat     2 YVKSIILEGFKSYAQRTEVNGFDPL--FNAITGLNGSGKSNILDSICFLLGISNLSQVRASNLQD 64

  Fly    87 LIHGSSIGKPVSRSCYVT------AKFVLNEERHMDF---QRAVIGGSSEYRINGESVSSSTYLN 142
            |::.:........|..:|      .:..|..|.|.:.   ::.||||.::|.|||.:.:::...:
  Rat    65 LVYKNGQAGITKASVSITFDNSDKKQSPLGFEAHDEITVTRQVVIGGRNKYLINGVNANNTRVQD 129

  Fly   143 KLEKIGINVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQF 207
            ....:|:||...:||:.||.:..:....|.|..::.||.:|:.:.  :|.::..:..:.::|.:.
  Rat   130 LFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMY--EYKKIAAQKTIEKKEAKL 192

  Fly   208 TYQKKKGIAAERKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQ-E 271
              ::.|.|..|......:|::.:|.:.|:.:...:::|: |.||:...:.:  ...|.:.|.. |
  Rat   193 --KEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEH-LSRLYIAYQFL--LAEDTKERSAGE 252

  Fly   272 VKAVEQRKEAADEILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLI 336
            :|.::.:.....|:|.|.:|       .:..::.||.|.|           |.|:|.|  ...|.
  Rat   253 LKEMQDKILKLQEVLSENEK-------KIKALNCEIEELE-----------KRKDKET--GGILR 297

  Fly   337 SLQKTLETAREADNAHQS--DIRKLEKQLADVEALKKRFEDEIENESQ---RRGKSV-NMEEGL- 394
            ||:.....|:..:...||  |::|  |.||..|..:|..|..:..:|:   .:.|.| .:.:||
  Rat   298 SLEDAFAEAQRVNTKSQSAFDLKK--KNLASEETKRKELEKNMAEDSKALAAKEKEVKKLTDGLH 360

  Fly   395 -VQEYDRLKQEAEATATQYRSELDSVNREQKSEQD----TLDGE--------TNRRASVEESFKK 446
             :||......||.|.|.|:   .::|:....|.:|    ||.|:        :..:...:::..|
  Rat   361 GLQEASNKDAEALAAAQQH---FNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTGAKQAQMK 422

  Fly   447 LTLQREEAVKRRDKL--MDH-IKSSQAALEEQNRIKDELRRDV------GTSKEKIAEKQREL-E 501
            |...::|...::.::  ||. .|..|.|.|...::|::|..::      ...:|::.||.|:: .
  Rat   423 LKHAQQELKNKQAEVRKMDSGYKKDQEAFEAVKKVKEKLETEMKKLNYEDNKEERLLEKHRQVSR 487

  Fly   502 DVRDQLG--DAKSDKHEDARRKKKQEVVELFKKQVPGVYDRMINMCQPTHKRYNVAVTKVLGKFM 564
            |:.:..|  :|...|..:.|...|.......:..|.|:...:||:   .......|:..|.|:.:
  Rat   488 DISNLKGTYEALLAKFPNLRFAYKDPEKNWNRNCVKGLVASLINV---KDNSTATALELVAGERL 549

  Fly   565 EAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPL-KERLR---NISDPRNVRLVFDVLKF 625
            ..::||||.|.:..::  |.::....|.:||:.:..:.: .|.||   |:..|.||.:...::.:
  Rat   550 YNVVVDTEVTGKKLLE--KGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPNNVHVALSLVDY 612

  Fly   626 EPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALALDGTFYQKSGLISGGSHDLARKAK 690
            :| |:::|:.|..|...||...::|.|||:: .|.....:.|.|..:...|.:|||:...|..
  Rat   613 KP-ELQKAMEFVFGTTFVCNNMDNAKKVAFD-KRIMTRTVTLGGDVFDPHGTLSGGARSQAAS-- 673

  Fly   691 RWDEKHMAQLKMQKERLQEELKELVKKSR-KQSELATVESQIKGLEN------------RLKYSM 742
                   ...|.|      |||::..:.| |:.||..:|.::.||:|            .:|...
  Rat   674 -------ILTKFQ------ELKDVQAELRTKEKELQALEEELAGLKNVAEKYRQLKQQWEMKTEE 725

  Fly   743 VDLESSKKSISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIKENMNNVEDKVYASFCR 807
            .||..:|...|.|..|    |.:||.....|.|.|..::|.:|..::.:|....:|:|
  Rat   726 GDLLQTKLQQSSYHKQ----QEELDALKKTIEESEETLKNTKEIQKKAEEKYEALENK------- 779

  Fly   808 RLGVKNIRQYEERELVMQQER-----------ARKRAEFEQQIDSINSQLDFEKQKDTKKNVERW 861
               :||.....|:||...|::           ::|..|.:|::::|..:|: |.:::...|.::.
  Rat   780 ---MKNAEAEREKELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELE-ELKREHASNEQQL 840

  Fly   862 ERSVQDEEDALEG-LKLAEARYLKEIDEDKEKMEKFKQDKQAKKQAVDDMEEDISKARKDVANLA 925
            : :|.:...|.|| :::..|    |:.::||.:.| .|::..|::.:...:::|.|.:  .|.:|
  Rat   841 D-AVNEAIKAYEGQIEIMAA----EVAKNKESVNK-AQNELMKQKEIISAQDNIIKDK--CAEVA 897

  Fly   926 KEIHNVGSHLSAVESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVRQSDPDVPSTSAAMEN 990
            |  ||:.::    :|:::.|:                       ||.::.:...:....:|.:..
  Rat   898 K--HNLQNN----DSQLKIKE-----------------------LDHSISKHKREADDAAAKVSK 933

  Fly   991 IIEVDYSSLPRE-YTKLKDDSAF-------KKTHEMLQKDLQSKLDVLERI-QTPNMKALQKLDA 1046
            ::. ||..:..| :...:.:||:       |:..:.||| ||   :|.|:: :..||:|:..|..
  Rat   934 MLN-DYDWINAEKHLFGQPNSAYDFKTNNPKEAGQRLQK-LQ---EVKEKLGRNVNMRAMNVLTE 993

  Fly  1047 VTE-----------------KVQSTNEEFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAI 1094
            ..|                 |:.:|.|:.:  :||.:....|:::|..:..|.|       |..:
  Rat   994 AEERYNDLMKKKRIVENDKSKILATIEDLD--QKKNQALNIAWQKVNKDFGSIF-------STLL 1049

  Fly  1095 DGIYKKLARNEAAQAYIGPDNPE-EPYLDGINYNCVAPGKRF-QPMNNLSGGEKTIAALALLFST 1157
            .|          |.|.:.|  || :..|||:.:. ||.|..: :.:..||||::::.||:|:.|.
  Rat  1050 PG----------ANAMLAP--PEGQTVLDGLEFK-VALGNTWKENLTELSGGQRSLVALSLILSM 1101

  Fly  1158 HSFHPAPFFVLDEIDAALDNTNIGKVASYIRDHTTNLQTIVISLKEEFYGHADAL 1212
            ..|.|||.::|||:|||||.::...:...:|.|.|:.|.||:||||..:.:|:.|
  Rat  1102 LLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMFNNANVL 1156

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	316/1290 (24%)
		ABC_SMC1_euk	27..>171	CDD:213242	49/156 (31%)
		SMC_hinge	535..653	CDD:214944	30/121 (25%)
		DUF4700	<697..>810	CDD:292399	31/125 (25%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	34/84 (40%)
Smc2	NP_001102136.2	Smc	1..1168	CDD:224117	316/1290 (24%)
		ABC_SMC2_euk	1..>172	CDD:213240	54/171 (32%)
		L_lactis_ph-MCP	252..>465	CDD:115336	57/237 (24%)
		SMC_hinge	522..639	CDD:214944	31/122 (25%)
		PCRF	693..>761	CDD:305100	19/71 (27%)
		DUF4200	740..841	CDD:290574	25/115 (22%)
		P-loop_NTPase	<1074..1168	CDD:304359	33/83 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810