DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC1 and SMC3

DIOPT Version :9

Sequence 1:NP_651211.2 Gene:SMC1 / 42853 FlyBaseID:FBgn0040283 Length:1238 Species:Drosophila melanogaster
Sequence 2:NP_523374.2 Gene:SMC3 / 32627 FlyBaseID:FBgn0015615 Length:1200 Species:Drosophila melanogaster


Alignment Length:1336 Identity:317/1336 - (23%)
Similarity:565/1336 - (42%) Gaps:313/1336 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 LEYIEMENFKSYRGHIVVGPL-KQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIHG 90
            ::.|.::.||||:...||.|. |:.|.|:|.||||||||..||.||:.::.:.||.::...|:|.
  Fly     3 IKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSDEFTHLRPEQRQSLLHE 67

  Fly    91 SSIGKPVSRSCYVTAKFVLNEER-HMD----FQRAVIGG-SSEYRINGESVSSSTYLNKLEKIGI 149
            .:..:.:  |.||...|..::.| .:|    |.|.|||. ..:|.:|.:.|..:..:|.||..|.
  Fly    68 GTGARVI--SAYVEIIFDNSDNRVPIDKEEIFLRRVIGAKKDQYFLNKKVVPRNEVVNLLESAGF 130

  Fly   150 NVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQKKKG 214
            :.....::|.||.:..:|......|..|..|::|:.:    |:..|:|.:....||.        
  Fly   131 SSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRV----YDERKEESLNLLRETD-------- 183

  Fly   215 IAAERKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQEVKAVEQRK 279
             :...|.:::.|...||...|:.| .|:..|||.:         .|....||..:.|.: ::..|
  Fly   184 -SKVEKISEYLKTIEDRLQTLEEE-KEELKEYQKW---------DKTRRTLEYIRYETE-LKDTK 236

  Fly   280 EAADEILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKTLET 344
            :|.||:..::|..:.|         ::|...|.|         ||:||:...:|.|...:|.:::
  Fly   237 KALDELQLQRKSSSDK---------KKIYNIEIQ---------KAQEKIKDVQKNLKEAKKKVQS 283

  Fly   345 AREADNAHQSDIRKL--EKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLVQEYDRLKQEAEA 407
            .:|..:...::.::|  ||...|:..:....|.:.:|:|:.|..         ||...||    .
  Fly   284 TKEERSVLMTEQQQLLREKTKLDLTIVDLNDEVQGDNKSKERAD---------QELKNLK----V 335

  Fly   408 TATQYRSELDSVN-------------------REQK-SEQDTLDGETNRRASVEESFKKLTLQRE 452
            |..:...|||.|.                   :||| .|.....|..::.:|.|:..|.:|.:.:
  Fly   336 TIAEREKELDDVKPKYEAMKRKEEDCSRELQLKEQKRKELYAKQGRGSQFSSREDRDKWITNELK 400

  Fly   453 EAVKR-RDKLMDHIKSSQAALEEQNRIKDELRRDVGTSK---EKIAEKQRELEDVRDQLGDAKSD 513
            ...|: |||:..|.|           :.::|::|..:.|   :||.|...|||.:|.|: |..:.
  Fly   401 SISKQTRDKIAHHAK-----------LVEDLKKDATSEKDLGQKIEEHSSELEQLRLQI-DEHNK 453

  Fly   514 KHEDARRKKKQEVV---ELFKKQVPGVYDRMINMCQPTHK----RYNVA---------------V 556
            |:.:.::.|.|...   ||::|:.     :|....| |||    |.:.|               |
  Fly   454 KYYELKKTKDQHQSMRNELWRKET-----QMTQQLQ-THKEELSRADQALRSMAGKPILNGCDSV 512

  Fly   557 TKVLGKFME------------------------AIIVDTEKTA-----RHCI-------QILKEQ 585
            .|||..|:|                        .|....|.||     .|.:       |||||.
  Fly   513 RKVLDSFVERGGQSAEIARAYYGPVIENFSCDKTIYTAVEVTAANRLFHHIVESEYEGTQILKEM 577

  Fly   586 ML-----EVETFLPLDYLQVK----PLKERLRNISDPRNVRLVFDVLKFEPQEIERAVLFATGNA 641
            ..     || ||:||:.||||    |        .||.::.:: ..||::.|. ::|:.:..|..
  Fly   578 NKLKLPGEV-TFMPLNRLQVKIHDYP--------DDPDSIPMI-SKLKYDEQH-DKALRYIFGKT 631

  Fly   642 LVCETPEDAMKVAYEIDRSRFDALALDGTFYQKSGLISGGSHDLARKAKRWDEKHMAQLKMQKER 706
            |:|...|.|.::|   ..:..|.:.|||......|.::||..:.:|          ::|:|||:|
  Fly   632 LICRNLERATELA---KSTGLDCVTLDGDQVSSKGSLTGGYFNTSR----------SRLEMQKKR 683

  Fly   707 LQ--EELKELVKKSRKQSELATVESQIKGLENRLKYSMVDLESSKKSISQYDNQLQQVQSQLDEF 769
            .:  .::.|..||      |:.:.:::|..||.:...:.:::.::....:..:..::||.::...
  Fly   684 TEYTSQIAEFEKK------LSKLRNELKSTENNINSIVSEMQKTETKQGKSKDVFEKVQGEIRLM 742

  Fly   770 GPKILEIERRMQNREEHIQEIK---ENMNNVEDKVYASFCRRLGVKNIRQYEERELVMQQERARK 831
            ..:::.||:....:|..:.:.|   |:|.:.:..:.|...:.| :..:...::||:....:..|:
  Fly   743 KEELVRIEQYRAPKERSLAQCKASLESMTSTKSSLEAELKQEL-MSTLSSQDQREIDQLNDDIRR 806

  Fly   832 RAEFEQQIDSINSQLDFEKQKDTKKNV--------------ERWERSVQDEEDALEGLKL----A 878
            ..  ::..::...::.||.:|:...|:              ...|.||:|.:..|...|.    |
  Fly   807 LN--QENKEAFTQRMQFEVRKNKLDNLLINNLFRRRDELIQALQEISVEDRKRKLNNCKTELVSA 869

  Fly   879 EARYLKEIDEDKEKMEK-FKQDKQAKKQAVDDMEEDISKARKDVANLAKEIHNVGSHLSAVESKI 942
            |.| :|:::.|.|::|| ..:..|.:|:...::|..:.|.::...||.|            :||.
  Fly   870 EKR-IKKVNSDLEEIEKRVMEAVQLQKELQQELETHVRKEKEAEENLNK------------DSKQ 921

  Fly   943 EAKKNERQNILLQAKTDCI-------VVPLLRGSLDDAVRQSDPDVPSTSAAMENIIEVDYSSLP 1000
            ..|.:.::|:|.:...:|.       .|||:           ||..  |..:::||    :..|.
  Fly   922 LEKWSTKENMLNEKIDECTEKIASLGAVPLV-----------DPSY--TRMSLKNI----FKELE 969

  Fly  1001 REYTKLKDDS-----------AFKKTHEMLQKDLQSKLDVLER-----IQTPNMKALQKLDAVTE 1049
            :....||..:           :|.:..|.|.: .:.:||:.::     ||:..|   ||::|:..
  Fly   970 KANQHLKKYNHVNKKALDQFLSFSEQKEKLYR-RKEELDIGDQKIHMLIQSLEM---QKVEAIQF 1030

  Fly  1050 KVQSTNEEFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEAAQAYIGPD 1114
            ..:...:.|....||.....|.|..:|.:.:..            |.:.|::   |.:.|:.|  
  Fly  1031 TFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEG------------DEMEKEV---ENSDAFTG-- 1078

  Fly  1115 NPEEPYLDGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTN 1179
                   .||..:........:.||.||||:|::.||||:||.....||||::.||||.|||..:
  Fly  1079 -------IGIRVSFTGVEAEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQALDAMH 1136

  Fly  1180 IGKVASYIRDHTTNLQTIVISLKEEFYGHADALVGI 1215
            ...||:.|.:.:...|.|..:.:.|...:|....|:
  Fly  1137 RKAVANMIHELSDTAQFITTTFRPELLENAHKFYGV 1172

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC1NP_651211.2 Smc 26..1216 CDD:224117 317/1336 (24%)
ABC_SMC1_euk 27..>171 CDD:213242 50/150 (33%)
SMC_hinge 535..653 CDD:214944 45/181 (25%)
DUF4700 <697..>810 CDD:292399 21/117 (18%)
ABC_SMC1_euk <1130..1232 CDD:213242 32/86 (37%)
SMC3NP_523374.2 SMC_N 2..1180 CDD:280601 317/1336 (24%)
ABC_SMC3_euk 3..>159 CDD:213239 51/157 (32%)
SMC_hinge 533..643 CDD:214944 32/120 (27%)
TMPIT 678..>760 CDD:285135 16/87 (18%)
CHD5 <780..>822 CDD:282299 4/44 (9%)
P-loop_NTPase <1088..1182 CDD:304359 32/85 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45464470
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.740

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