DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC1 and SMC5

DIOPT Version :9

Sequence 1:	NP_651211.2	Gene:	SMC1 / 42853	FlyBaseID:	FBgn0040283	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_996141.2	Gene:	SMC5 / 326215	FlyBaseID:	FBgn0052438	Length:	1034	Species:	Drosophila melanogaster

Alignment Length:	1258	Identity:	237/1258 - (18%)
Similarity:	440/1258 - (34%)	Gaps:	413/1258 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ENFKSYRGHIVVGPLKQFNAVIGPNGSGKSNFMDAI------------------SFVMGEKTSSL 79
            ::|.|| ..|...|....|.:.||||||||..:.||                  .::...|||:.
  Fly    22 KDFVSY-SEITFHPKHYLNVLTGPNGSGKSTIVSAIILGLGGEPILLDRSASVADYIQSNKTSAT 85

  Fly    80 RVKRLNDLIHGSSIGKPVSRSCYVTAKFVLNEERHMDFQRAVI--GGSSEYRINGESVSSSTYLN 142
            .:.|    ::|        |:...|..|           |.:|  .|.|.:.:|.:..|...:|.
  Fly    86 IIVR----VYG--------RTPNTTETF-----------RRIINSNGLSTFSVNDKDTSKKNFLA 127

  Fly   143 KLEKIGINVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLK------------DDYNRLK 195
            .:....|.            |.|:....|::|...|.:::...||.            :.:|.||
  Fly   128 AVSSFNIQ------------VSNLCQFLPQDRVQDFSKMNPQELLLNTMSSVCDEDLINSFNSLK 180

  Fly   196 QEMIVAEEETQFTYQKKKG-IAAERKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIR 259
            | |...:.......:|:|. :..::|..:|.:|...:| :.:.|..:|...|...:|:
  Fly   181 Q-MRTEQANVHANREKEKSDLVKKQKRLEHLQMTVSQY-KEREEVKQKLQVYSAKKLW------- 236

  Fly   260 KFTSDLEVRQQEVKAVEQRKEAADEILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKA 324
                 :|.:..|.||.|.:.:     ::..|..:.|:.....|:.|...:.|           |.
  Fly   237 -----VETQAGEAKAAEMKTQ-----VKNAKTQSDKLKNQHDKLLQSQEQIE-----------KE 280

  Fly   325 KEKVTHCKKKLISLQKTLETAREADNAHQSDIRKLEKQLADVEALKKRFEDEIENESQRRGKSVN 389
            ||.:   :|.|  |:||               |.||..:|:..|:.              ||..:
  Fly   281 KESL---RKAL--LEKT---------------RLLENAVAEKAAID--------------GKMDS 311

  Fly   390 MEEGLVQEYDRLKQ---EAEATATQYRSELDSVNR--EQK-SEQDTLDGETNRRASVEESFKKLT 448
            :::|:.|:...|:|   ::..|||    |.|::|:  |.| .|.:||:  .:|...|.|    |.
  Fly   312 LKQGIYQKKYELEQNIKKSRRTAT----ECDNLNQLVENKIYELETLN--KSRPLIVSE----LE 366

  Fly   449 LQREEAVKRRDKLMDHIKSSQAALEEQNRIKDELRRDVGTSKEKIAEKQRELEDVRDQLGDAKSD 513
            ..:|.....|.|.|:.. |.:..||:  ::.||:..::...|.||           ::|.:.|..
  Fly   367 RAKESCAAARGKAMEQY-SRRRQLEQ--KLNDEMIPEITAYKLKI-----------ERLRNVKMQ 417

  Fly   514 KHEDARRKKKQEVVEL------FKKQVPGVYDRMI-NMCQPTHKRYNVAVTKVLGKFMEAIIVDT 571
            |.::.|.|....||.:      .::....|||.|| .:....|:.         .||:|.::...
  Fly   418 KIDEIRAKNPNLVVAMNWLAQNKQRYKLNVYDPMILELTVQNHED---------AKFLENVVAQR 473

  Fly   572 EKTARHC----------IQILKEQMLEVETF--LPLDYLQVKPLK--ERLRN----------ISD 612
            :..|..|          .::..:|.|.|...  .|.|.|...|..  :.||:          ::.
  Fly   474 DLFAFACEDKGDMSDLINELCVKQKLGVNVIYCAPSDRLVYSPKTPIDDLRSFGFRSYLVDLVTG 538

  Fly   613 P-------------RNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDA 664
            |             .|:.:..:.:......|.:|:....|.         :.|......|.|.|.
  Fly   539 PIPLINKLCASYSIHNIPIGTEAVGNYTSSIPKAIRVYFGG---------SKKFVVTASRYRSDT 594

  Fly   665 LALDGTFYQKSGLISGGSHDLARKAKRWDEKHMAQLKMQKERLQEELKELVKKSRKQSELATVES 729
            :..:.:...|:.||:..|..||                   .:.::..|.||:|
  Fly   595 ILTESSIRAKNQLITVDSQQLA-------------------LVMKQCSEAVKES----------- 629

  Fly   730 QIKGLENRLKYSMVDLESSKKSISQYDNQLQQVQS-QLDEFGPKILEIERRMQNREEHIQEIKEN 793
                            :|.|.:|:|.||:.:::|: ..||     .|..|::..:..|...:|..
  Fly   630 ----------------DSIKNAITQTDNEFERLQAVAKDE-----QEKRRKLDQKIAHFNSLKTE 673

  Fly   794 MNNVEDKVYA------------SFCRRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSINSQL 846
            :..::.|:.|            :||..|. |::::..:.:           ||....:.:|:..:
  Fly   674 IETLQKKLEALRNSDSLDCLETNFCNSLH-KDLKKIFDAD-----------AELCSCLKAIDRLI 726

  Fly   847 DFEKQKDTKKNVERWERSVQDEEDALEGLKLAEARYLKEIDEDKEKMEKFKQDKQAKKQAVDDME 911
            ..:....||.::...:...|     :|.||           |.:|:.:...:|.|...|.:::..
  Fly   727 IEKNMAQTKVSIYMLQHETQ-----IEALK-----------ESEEQSKAATRDFQQLLQCLENQI 775

  Fly   912 EDISKARKDVANLAK-EIHNVGSHLSAVESKIEAKK--NERQNILLQAKTDCIVVPLLRGSLDDA 973
            .|::|.:..:..|.. ||        ...||...||  .|.:||
  Fly   776 SDVNKRKSAIQGLCHGEI--------PTSSKFPFKKEFRELENI--------------------- 811

  Fly   974 VRQSDPDVPSTSAAMENIIEVDYSSLPREYTKLKDDSAFKKTHEMLQKDLQSKLDVLERIQTPNM 1038
                  |:|....|:.                                |.|::|:.::.:   |.
  Fly   812 ------DLPELREAIH--------------------------------DFQARLECMKSV---NS 835

  Fly  1039 KALQKLDAVTEKVQSTNEEFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLAR 1103
            :|:.....:..:|:...|..:.:..:||..::....:.::...:       ::..::.|..|.:.
  Fly   836 EAISSYQGLQNEVKQLEEGIQESVNQAKSIESGMSNLYDKWEPK-------LNSLVETISTKFSE 893

  Fly  1104 NEAAQAYIGP---DNPEEPYLDGINYNCVAP---GKRFQPMNNL--SGGEKTIA----ALALLFS 1156
            ...:..|:|.   ...::...|......:..   |.:.||::..  ||||:.::    :|:|...
  Fly   894 FMESIEYVGEVVLSKTDKYDFDSYGIQIMVQFRRGLQLQPLDKFIQSGGERAVSIAIYSLSLQHV 958

  Fly  1157 THSFHPAPFFVLDEIDAALDNTN 1179
            ||    .||..:|||:..:|.||
  Fly   959 TH----VPFRCVDEINQGMDATN 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	237/1258 (19%)
		ABC_SMC1_euk	27..>171	CDD:213242	34/157 (22%)
		SMC_hinge	535..653	CDD:214944	25/155 (16%)
		DUF4700	<697..>810	CDD:292399	21/125 (17%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	19/59 (32%)
SMC5	NP_996141.2	ABC_SMC5_euk	14..>160	CDD:213244	37/173 (21%)
		Smc	22..1011	CDD:224117	237/1258 (19%)
		GrpE	212..>316	CDD:295646	31/166 (19%)
		ABC_SMC5_euk	<919..1025	CDD:213244	19/63 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900