DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC1 and smc3

DIOPT Version :9

Sequence 1:NP_651211.2 Gene:SMC1 / 42853 FlyBaseID:FBgn0040283 Length:1238 Species:Drosophila melanogaster
Sequence 2:NP_999854.1 Gene:smc3 / 324475 ZFINID:ZDB-GENE-030131-3196 Length:1216 Species:Danio rerio


Alignment Length:1374 Identity:301/1374 - (21%)
Similarity:554/1374 - (40%) Gaps:362/1374 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 FLEYIEMENFKSYRGHIVVGPL-KQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIH 89
            :::.:.::.|:|||...||.|. .:.|.::|.||||||||..||.||:.::.|.||.::...|:|
Zfish     2 YIKQVIIQGFRSYRDQTVVDPFGSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLH 66

  Fly    90 GSSIGKPVSRSCYVTAKFVLNEER------HMDFQRAVIGGSSEYRINGESVSSSTYLNKLEKIG 148
            ..:  .|...|.:|...|..::.|      .:..:|.:.....:|.::.:.|:.:..:|.||..|
Zfish    67 EGT--GPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAG 129

  Fly   149 INVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQKKK 213
            .:.....::|.||.:..:|.....:|..|..|::|:.:    |:..|:|.|...:||        
Zfish   130 FSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRV----YDERKEESISLMKET-------- 182

  Fly   214 GIAAERKEAKHEKME------ADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQEV 272
                   |.|.||:.      .:|...|::| .|:..:||.:       |..:...:..:..|| 
Zfish   183 -------EGKREKINELLKYIEERLHTLEDE-KEELAQYQKW-------DKMRRALEYTIYNQE- 231

  Fly   273 KAVEQRKEAADEILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLIS 337
              :.:.:...|| |..|::..|..:|.|....|:.|:           .::..|:|....|..||
Zfish   232 --LNETRAKLDE-LSSKRETCGDKSRQLRDAQQDARD-----------KVEETERVVRELKSRIS 282

  Fly   338 LQKTLETAREADNAHQSDIRKLEKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLVQEYDRLK 402
            ..|..:....|:...|.      ||...:|...|..:||:...|::|.:.:...:.|:::.:..:
Zfish   283 AMKEEKEQLSAERQEQI------KQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQ 341

  Fly   403 QEAEATATQYRS----ELDSVNREQKSEQDTLD-----GETNRRASVEES---FKKLTLQREEAV 455
            :|.:.|..::.:    |...:.|..::.|:..|     |..::..|.||.   .||.....::|:
Zfish   342 KELQETEPKFNTVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAI 406

  Fly   456 --KRRD------KLMDHIKSSQAALEEQNRIKDELRRDVGTSKEKIAEKQRELEDVRDQL----- 507
              |:|.      .|.|..::.:..||:.|::..:| .:|.|..|::.:|..|:::.:|:|     
Zfish   407 NDKKRQIAAIHKDLEDTEQNKERNLEQYNKLDQDL-NEVKTRVEELDKKYYEVKNRKDELQSERN 470

  Fly   508 ---------GDAKSDKHEDARRKKK-----------------QEVVELFKKQVPGVYDRMIN--- 543
                     ..|.:.|.||..:|::                 .:|:|.|:::  |:...:||   
Zfish   471 YLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLEHFRRK--GINQHVINGYH 533

  Fly   544 -------MCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVE-TFLPLDYLQV 600
                   .|:|.   :...|....|..:...||:|::.:...:....:..|..| |||||..|.|
Zfish   534 GIVMNNFECEPA---FYTCVEVTAGTRLFYHIVETDEVSTKILMEFNKMNLPGEVTFLPLSKLDV 595

  Fly   601 KPLKERLRNISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRS-RFDA 664
            :.......|.:.|...:|.:.      |..::|.....|..|:|.    :|:|:.::.|: ..|.
Zfish   596 RDTAYPETNDAIPMISKLRYS------QNFDKAFKHVFGKTLICR----SMEVSTQLARAFTMDC 650

  Fly   665 LALDGTFYQKSGLISGGSHDLARKAKRWDEKHMAQLKMQKE--RLQEELKELVKKSRKQSELATV 727
            :.|:|......|.::||.:| .||::         |::||:  :.:|||.||..|          
Zfish   651 ITLEGDQVSHRGALTGGYYD-TRKSR---------LELQKDMRKAEEELGELEAK---------- 695

  Fly   728 ESQIKGLENRLKYSMVDLESSKKSISQYDNQLQQVQSQLDEFGP---------KILEIERRMQNR 783
                  |...|:.   ::|:....|.|..||:||:::|..:|..         |:|: |:|.|: 
Zfish   696 ------LNENLRR---NIETINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLK-EKRQQS- 749

  Fly   784 EEHIQEIKENMNNVEDKVYASFCRRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSINSQLDF 848
            |:.....:.::.::|..::|                    |:..|...:||...   .:.|||..
Zfish   750 EKTFMPKQRSLQSLEASLHA--------------------MESTRESLKAELGA---DLLSQLSL 791

  Fly   849 EKQK------DTKKNVERWERSVQDEEDALEGLKLAEARYL-----KEIDEDKEKMEKFKQ---- 898
            |.|:      |..:.:::..|.:.:|...|||:......||     |.:|:.::::.:.::    
Zfish   792 EDQRRVDDLNDEIRQLQQDNRQLLNERIKLEGIMTRVETYLNENLRKRLDQVEQELNELRETEGG 856

  Fly   899 ------------------DKQAKKQ----AVDDMEEDISKARKDV---ANLAKEIHNVGSHLSAV 938
                              |..|:.:    .:|..|.:|.:.:|.:   .|:.||.:...:|    
Zfish   857 TVLTATTSELDGINKRIKDTMARSEDLDTLIDKTEVEIKEHQKSMERWKNIEKEQNEAINH---- 917

  Fly   939 ESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVRQSDPDVPSTSAAMENIIEVDYSSLPREY 1003
            ::|...|...||.:||:.|.:|                           |:.|.|:  .|||:| 
Zfish   918 DTKELEKMTNRQGMLLKKKEEC---------------------------MKKIREL--GSLPQE- 952

  Fly  1004 TKLKDDSAFKKTHEMLQKDLQSKLD----VLERIQTPNMKALQK---LDAVTEKVQSTNEEFENA 1061
                   ||:|...:..|.|..||:    .|::....|.|||.:   .....||:....:|.:..
Zfish   953 -------AFEKYQTLTLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQDELDRG 1010

  Fly  1062 RKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARN--EAAQAYI------------- 1111
            .|.........|..|.|              ||...:|::::|  |..|..:             
Zfish  1011 YKSIMELMNVLELRKYE--------------AIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGD 1061

  Fly  1112 --GPDNPEE----------------PYLD---GINYNCVAPGKR--FQPMNNLSGGEKTIAALAL 1153
              |..:.:|                |.:|   |:.......||:  .:.|..||||:|::.||||
Zfish  1062 TEGGQSQDEGEGGDSERASSSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALAL 1126

  Fly  1154 LFSTHSFHPAPFFVLDEIDAALD-------NTNIGKVASYIRDHTTNLQTIVISLKEEFYG---- 1207
            :|:.....||||::.||||.|||       :..|.::|.:.:..||..:..::...::|||    
Zfish  1127 IFAIQKCDPAPFYLFDEIDQALDAQHRKAASDMIMELAGHAQFITTTFRPELLESADKFYGVKFR 1191

  Fly  1208 ----HADAL 1212
                |.|.:
Zfish  1192 NKVSHIDVI 1200

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC1NP_651211.2 Smc 26..1216 CDD:224117 301/1374 (22%)
ABC_SMC1_euk 27..>171 CDD:213242 42/150 (28%)
SMC_hinge 535..653 CDD:214944 28/128 (22%)
DUF4700 <697..>810 CDD:292399 28/123 (23%)
ABC_SMC1_euk <1130..1232 CDD:213242 33/100 (33%)
smc3NP_999854.1 Smc 1..1193 CDD:224117 299/1365 (22%)
ABC_SMC3_euk 3..>158 CDD:213239 43/156 (28%)
RILP-like <222..337 CDD:304877 28/135 (21%)
BAR <388..>482 CDD:299863 20/94 (21%)
SMC_hinge 530..642 CDD:214944 27/124 (22%)
MIT_CorA-like <700..>836 CDD:294313 35/163 (21%)
P-loop_NTPase <1104..1198 CDD:304359 31/93 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1196
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18937
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.910

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