DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SMC1 and smc2

DIOPT Version :9

Sequence 1:NP_651211.2 Gene:SMC1 / 42853 FlyBaseID:FBgn0040283 Length:1238 Species:Drosophila melanogaster
Sequence 2:NP_955836.2 Gene:smc2 / 321452 ZFINID:ZDB-GENE-030131-105 Length:1199 Species:Danio rerio


Alignment Length:1316 Identity:302/1316 - (22%)
Similarity:551/1316 - (41%) Gaps:290/1316 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 FLEYIEMENFKSYRGHIVVGPLKQ-FNAVIGPNGSGKSNFMDAISFVMG-EKTSSLRVKRLNDLI 88
            :::.|.:|.||||.....:..... |||:.|.|||||||.:|:|.|::| ...|.:|...|.||:
Zfish     2 YIKSIVLEGFKSYAERTEINGFDPFFNAITGLNGSGKSNILDSICFLLGISNLSQVRATNLQDLV 66

  Fly    89 HGSSIGKPVSRSCYVT------AKFVLNEERHMDF---QRAVIGGSSEYRINGESVSSSTYLNKL 144
            :.:.:......:..:|      .:..|..|.|.:.   ::.||||.::|.|||.:.::....:..
Zfish    67 YKNGLAGITKATVSITFDNSNKKQSPLGFETHDEITITRQVVIGGRNKYLINGVNANNLRVQDLF 131

  Fly   145 EKIGINVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLL------------KDDYNRLKQE 197
            ..:|:||...:||:.||.:..:....|.|..|:.||.:|:.:.            |.| .:||:.
Zfish   132 CSVGLNVNNPHFLIMQGRITKVLNMKPPEILAMIEEAAGTRMYECKKISAQKTIEKKD-AKLKEI 195

  Fly   198 MIVAEEETQFTYQKKKGIAAERKEAKHEKMEADRYTRLQNEY------------NEKQVEYQLFR 250
            ..:.:||.....:|.|...|...|.:....|.:..:||...|            ||:..|.|   
Zfish   196 QTILDEEITPAMEKLKEERASYLEYQKLMREIEHLSRLYVAYLFVCAEETKLKSNEELQEMQ--- 257

  Fly   251 LFHVERDIRKFTSDLEVRQQEVKAVEQRKEAADEILREKKKDAGKITRDLAKIDQEIREFETQMN 315
                 ..|.|...::  :|.|.|..|...| ..|:.|.:.|:.|.:.|.|.:...|.:..:|:..
Zfish   258 -----SSIAKLQENM--KQNEAKVKELSAE-IQELERRRDKEVGGVLRTLEETLSEAQRVDTKAQ 314

  Fly   316 KRRPLYIKAKEKVTHCKKKLISLQKTLETAREADNAHQSDIRKLEKQLADVEALKKRFEDEIENE 380
            ....|   .|:.:....||...|.|.:|..::..:|.::::.|..::|..|:...::..:.:|..
Zfish   315 SALDL---KKQNLKDETKKRKELVKNMEEDKKVMSAKEAEVAKAVERLKAVKEEGQKDAEALEAA 376

  Fly   381 SQR-----RGKSVNMEEG---------LVQEYDRLKQEAEATATQYR------------SELDSV 419
            .|.     .|.|.| |:|         :..:.|..|.|.||...|.:            :::..:
Zfish   377 QQHFKAVSAGLSAN-EDGAEATLSGQMMTCKNDISKAETEAKQAQMKLKHAQQELKTKQAQVKKM 440

  Fly   420 NREQKSEQDTLDGETNRRASVEESFKKLTLQ--REEAVKRRDKLMDHIKSSQAALEEQNRIKDEL 482
            :...|.:|||.:........::...|||..:  |||                 .|.||.|   :.
Zfish   441 DSGYKKDQDTFEAVNKCIEKLQAEMKKLNYEDGREE-----------------CLLEQKR---QF 485

  Fly   483 RRDVGTSKEKIAEKQRELEDVRDQLGDAKSDKHEDARRKKKQEVVELFKKQVPGVYDRMINMCQP 547
            .|:|...:|.......:..::|.:..|.:.:..   |.|.|..|..||         .:.::...
Zfish   486 SREVIQLREAYESLMGQFPNLRFEYTDPERNWE---RSKVKGLVANLF---------TVTDVSNA 538

  Fly   548 THKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPLKERL----R 608
            |      |:..|.|..:..::||.|.|.:..::  |.::....|.:||:.:..:.|.:.:    :
Zfish   539 T------ALEVVAGGRLYNVVVDNEVTGKKLLE--KGELRRRYTIIPLNKISARTLNDNVVRTAK 595

  Fly   609 NISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALALDGTFYQ 673
            .:..|.||.....::.:| .|:.:|:.:..|..|||::.::|.|||::...|. ..:.|.|..:.
Zfish   596 KLVGPDNVHTALSLVGYE-SELRKAMEYVFGTTLVCDSLDNAKKVAFDKGVST-KTVTLGGDVFD 658

  Fly   674 KSGLISGGSHDLARKAKRWDEKHMAQLKMQKERLQEELKELVKKSRKQSELATVESQIKG----- 733
            ..|.::||       |:......:::|...|: :|:.|:      .|::||:.|||::.|     
Zfish   659 PQGTLTGG-------ARAQTASVLSKLAEVKD-IQDSLR------NKEAELSAVESELSGLKGTA 709

  Fly   734 -------------------LENRLKYS-----MVDLESSKKSISQYDNQLQ---QVQSQLDEFGP 771
                               ||.:|:.|     ..:||:.:|:|.:.::.||   :||.:.:|   
Zfish   710 EKYRQLKQQLDLKTEEARILETKLQQSSFHKQQEELENLRKTIEECEDTLQKTKEVQKKAEE--- 771

  Fly   772 KILEIERRMQN----REEHIQEIKENMNNVEDKVYASFCRRLGVKNIRQYEERELVMQ-QERARK 831
            |...:|.:|:|    ||:.::..::.:|..:.|..| |.:||..|   |.|...:.:: :|..|:
Zfish   772 KYNVLENKMKNAAAEREKELKAAQQKLNQAKSKADA-FSKRLKEK---QQEADAVALELEELKRE 832

  Fly   832 RAEFEQQIDSINSQLDFEKQKDTKKNVERWERSVQDEEDAL----EGLK------LAEARYLKEI 886
            :|.:||||.:::..|     |..::.::.....|...::|:    |.|.      :.:.|.:|..
Zfish   833 QAGYEQQIQAVDEAL-----KAVQEQIDNMTTEVSANKEAVRVAQEKLSQQKEVIMGQEREIKGK 892

  Fly   887 DEDKEKMEKFKQDKQAKKQAVDDMEEDISKARKDVAN--------------LAKEIHNVGSHLSA 937
            ..:..::.:...|.|.|   :.::|.:|||.:||.|:              ::.|.|..|...:|
Zfish   893 SGEANRLREQNNDAQLK---IKELEHNISKHKKDSADATAKVARMLAENDWISSEKHLFGQPNTA 954

  Fly   938 VESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVRQSDPDVPSTSAAMENIIEVDYSSLPRE 1002
            .:.|....|...|.:....:|        :..|:..|.:         .||..:.|.        
Zfish   955 YDFKTNNPKEAGQRLKRLEET--------KDKLERNVNR---------RAMNMLSEA-------- 994

  Fly  1003 YTKLKDDSAFKKTHEMLQKDLQSKLDVLERIQTPNMKALQKLDAVTEKVQSTNEEFENARKKAKR 1067
                          |....||:.|..::|     |.||         |:..|.||.:  :||.:.
Zfish   995 --------------EERYNDLKKKKRIVE-----NDKA---------KILETIEELD--QKKNEA 1029

  Fly  1068 AKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEAAQAYIGPDNPEEPYLDGINYNCVAPG 1132
            ...|:::|..:..|.|       |..:.|...:||..|....           |||:.:. ||.|
Zfish  1030 LNVAWQKVNKDFGSIF-------STLLPGANARLAPPEGCGV-----------LDGLEFK-VALG 1075

  Fly  1133 KRF-QPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTNIGKVASYIRDHTTNLQT 1196
            ..: :.:..||||::::.||:|:.:...|.|||.::|||:|||||.::...:...:|.|.|:.|.
Zfish  1076 NTWKENLTELSGGQRSLVALSLILAMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF 1140

  Fly  1197 IVISLKEEFYGHADAL 1212
            :|:|||:..:.:|:.|
Zfish  1141 VVVSLKDGMFTNANVL 1156

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMC1NP_651211.2 Smc 26..1216 CDD:224117 302/1316 (23%)
ABC_SMC1_euk 27..>171 CDD:213242 45/154 (29%)
SMC_hinge 535..653 CDD:214944 24/121 (20%)
DUF4700 <697..>810 CDD:292399 35/148 (24%)
ABC_SMC1_euk <1130..1232 CDD:213242 31/84 (37%)
smc2NP_955836.2 Smc 1..1170 CDD:224117 302/1316 (23%)
ABC_SMC2_euk 1..>156 CDD:213240 45/153 (29%)
L_lactis_ph-MCP 252..>465 CDD:115336 45/227 (20%)
SMC_hinge 522..639 CDD:214944 28/134 (21%)
DUF4200 740..841 CDD:290574 30/107 (28%)
P-loop_NTPase <1074..1169 CDD:304359 30/83 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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