Protein Alignment SMC1 and Smc1b

DIOPT Version :9

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: XP_038934778.1
• Gene: Smc1b / 300121
• RGDID: 1308791
• Length: 1249
• Species: Rattus norvegicus
• Alignment Length: 1225
• Identity: 498/1225 - (40%)
• Similarity: 763/1225 - (62%)
• Gaps: 18/1225 - (1%)

  Fly    27 LEYIEMENFKSYRGHIVVGPLKQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIHGS 91
            ||.:.:|||||:||..|:||.|:|..:||||||||||.|||:||||||||::||||.:.:||||:
  Rat     4 LELLLVENFKSWRGRQVIGPFKRFTCIIGPNGSGKSNVMDALSFVMGEKTTNLRVKNIQELIHGA 68

  Fly    92 SIGKPVSRSCYVTAKFVLNEERHMDFQRAV--IGGSSEYRINGESVSSSTYLNKLEKIGINVKAK 154
            .||||||.|..||..:|.:......|.|.:  .||.||:....:.||.|.|:.:||.|||.|||:
  Rat    69 HIGKPVSSSASVTIIYVEDSGEEKTFTRIIRGRGGCSEFHFGDKPVSRSVYVAQLENIGIIVKAQ 133

  Fly   155 NFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQKKKGIAAER 219
            |.|||||.||:|:||.|||||..|||||.||....:|...|:::..|||:.||.:.:||.:||||
  Rat   134 NCLVFQGTVESISMKKPKERTQFFEEISTSGEFIGEYEAKKKKLQKAEEDAQFHFNRKKNVAAER 198

  Fly   220 KEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQEVKAVEQRKEAADE 284
            |.||.||.||:.|..|..|....:::..||:|::.|..|....::||...:.:..|:......:.
  Rat   199 KHAKIEKEEAEHYQSLLEELKTNKIQLMLFQLYYNEEKINVLNTELEHMDRNLSVVKDTLSHHEN 263

  Fly   285 ILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKTLETAREAD 349
            |::.||||.|.:||.|.:..:|::..|..:|::||.||||||..:|..||| .|.|.|.|..|..
  Rat   264 IIKAKKKDYGMLTRQLQQTAKELKSVEAVLNQKRPQYIKAKENTSHHLKKL-DLSKKLITDNEKQ 327

  Fly   350 NAHQSD-IRKLEKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLVQEYDRLKQEAEATATQYR 413
            .|.|.| ||.|..:|.|::...:.||.::|.:...:|:.:.:|...:..|..||::.........
  Rat   328 CAKQEDGIRALVAELVDLDRAWRSFEKQMEEKILHKGRDIELENSQLDRYKELKEQVRRRVGIMT 392

  Fly   414 SELDSVNREQKSEQDTLDGETNRRASVEESFKKLTLQREEAVKRRDKLMDHIKSSQAALEEQNRI 478
            .:|:.:..|||:|::.|..|..|....:.:.|::..|.||..||.:||.::.|:....||::.:.
  Rat   393 QQLEKLQWEQKAEKERLAFERRRHGDTQGNLKQIKEQIEEHKKRIEKLEEYTKTCMDCLEDKKQQ 457

  Fly   479 KDELRRDVGTSKEKIAEKQRELEDVRDQLGDAKSDKHEDARRKKKQEVVELFKKQVP-GVYDRMI 542
            ::.|.:::..:|.:::|...||..:|::|.:|..|.||..|::|:.||:|..|:..| .|:.|::
  Rat   458 EEALIKEIDNTKSRMSEVNEELSLIRNELQNAGIDNHEGKRQRKRAEVLEHLKRLYPDSVFGRLL 522

  Fly   543 NMCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPLKERL 607
            ::|.|.||:|.:||||:.|::|.||:|.:||.|:.||:.|||:..|.||||.||||.:||:.|||
  Rat   523 DLCHPIHKKYQLAVTKLFGRYMVAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERL 587

  Fly   608 RNISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALALDGTFY 672
            |.|   :..:::.||:|.:..::::.:.|..||.|||||.|:|..:|:. ...|..|:|||||.:
  Rat   588 REI---KGCKMMIDVIKTQFPQLKKVIQFVCGNGLVCETVEEARHIAFG-GPERRKAVALDGTLF 648

  Fly   673 QKSGLISGGSHDLARKAKRWDEKHMAQLKMQKERLQEELKELVKKSRKQSELATVESQIKGLENR 737
            .|||:|||||.||..||..||||.:..|:.::.:|.:|||||:|..||:::|..:::.::|...|
  Rat   649 LKSGVISGGSSDLKHKALCWDEKELHSLRDKRNQLVQELKELMKTLRKETDLKQIQALVQGTNTR 713

  Fly   738 LKYSMVDLES-SKKSISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIKENMNNVEDKV 801
            ||||..:||. .||.::.:..:..|:||:|.....:...:...:..:::.|:|.::.::.|||.:
  Rat   714 LKYSQNELEMIKKKHLATFYREQSQLQSELLNIDSQCTMLSEGINKQQQKIEEFQDKIDKVEDDI 778

  Fly   802 YASFCRRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSINSQLDFEKQKDTKK--NVERWERS 864
            :..||..:||:|||::|.:.:..|||..:||.|||:|...:|.||::.:.:..||  .::..:.:
  Rat   779 FQDFCEEIGVENIREFENKHVKQQQENDQKRLEFEKQKTRLNIQLEYSRNQLKKKLNKIDTLKTT 843

  Fly   865 VQDEEDALEGLKLAEARYLKEIDEDKEKMEKFKQDKQAKKQAVDDMEEDISKARKDVANLAKEIH 929
            :|...:.::.||..|...||.::|...|.|:.|:....:...::.:...|.:.||....:.:|:.
  Rat   844 IQKGREDIDNLKKTEEECLKIVEELMVKQEQVKEVLATQSSNIEKIHIQIEEERKKFLAVDREVG 908

  Fly   930 NVGSHLSAVESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVRQSDPDVPSTSAA-----ME 989
            .:...:..::..:|.|:.|:.|:||..|...|.:.|:.|||:|.:.....:..||.|.     .|
  Rat   909 KLQKEVVIIQGSLEQKQLEKHNLLLDCKVQDIDISLMLGSLEDIIEVELTETESTQATADIYEKE 973

  Fly   990 NIIEVDYSSLPREYTKLKDDSAFKKTHEMLQKDLQSKLDVLERIQTPNMKALQKLDAVTEKVQST 1054
            ..|::|||.|..::..|:.|...:....:|.:.:.|:.:.|.:...||::|.:.|.||.:|.|.:
  Rat   974 ASIQIDYSPLREDWKALQSDKEVEAHLTLLLQQVASQENTLLKTAAPNLRAQENLKAVRDKFQES 1038

  Fly  1055 NEEFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEAAQAYIGPDNPEEP 1119
            .:.||.:||:|:..:..||:||..|...|..|.:|||.:||.|||||.||.:|||::.|:|||||
  Rat  1039 ADAFEASRKEARICRQEFEQVKRRRYDAFSQCFEHISVSIDQIYKKLCRNNSAQAFLSPENPEEP 1103

  Fly  1120 YLDGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTNIGKVA 1184
            |||||:||||||||||.||:|||||||.:|||||||:.|||.|||||||||:||||||||||||:
  Rat  1104 YLDGISYNCVAPGKRFMPMDNLSGGEKCVAALALLFAVHSFRPAPFFVLDEVDAALDNTNIGKVS 1168

  Fly  1185 SYIRDHT-TNLQTIVISLKEEFYGHADALVGITPGEGDCLVSNVYIMDLTTFEDT 1238
            .||::.: ...|.|:||||||||..||||:|:.|...:|:.|:|..:||:.:.||
  Rat  1169 GYIKEQSQEQFQMIIISLKEEFYSRADALIGVYPEHDECMFSHVLTLDLSKYPDT 1223

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	490/1201 (41%)
		ABC_SMC1_euk	27..>171	CDD:213242	82/145 (57%)
		SMC_hinge	535..653	CDD:214944	54/118 (46%)
		DUF4700	<697..>810	CDD:292399	32/113 (28%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	67/102 (66%)
Smc1b	XP_038934778.1	Smc	3..1201	CDD:224117	490/1201 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1149	1.000	Domainoid score	I16
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1173	1.000	Inparanoid score	I189
OMA	1	1.010	-	-		QHG53603
OrthoDB	1	1.010	-	-		D326079at2759
OrthoFinder	1	1.000	-	-		FOG0001963
OrthoInspector	1	1.000	-	-		otm45837
orthoMCL	1	0.900	-	-		OOG6_101499
Panther	1	1.100	-	-	O	PTHR18937
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1284
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840