DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC1 and Smc4

DIOPT Version :9

Sequence 1:	NP_651211.2	Gene:	SMC1 / 42853	FlyBaseID:	FBgn0040283	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_001032262.2	Gene:	Smc4 / 295107	RGDID:	1306680	Length:	1286	Species:	Rattus norvegicus

Alignment Length:	1319	Identity:	331/1319 - (25%)
Similarity:	591/1319 - (44%)	Gaps:	267/1319 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LEYIEMENFKSYRGHIVVGPL-KQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIHG 90
            :.:|..:|||||.|..::||. |:|:.:||||||||||.:|::.||.|.:...:|.|:|:.|||.
  Rat    82 ITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHN 146

  Fly    91 SSIGKPVSRSCYVTAKF------------VLNEERHMDFQRAVIGGSSEYRINGESVSSSTYLNK 143
            |.....: :||.|...|            ||........:.|....:|.|.|:|:..:.....|.
  Rat   147 SDEHTDI-QSCTVEVHFQKIIDKEGDDYDVLPNSNFYVSRTAYRDNTSVYHISGKKRTFKDVGNL 210

  Fly   144 LEKIGINVKAKNFLVFQGAVENIAMKTPKERT-------ALFEEISGSGLLKDDYNRLKQEMIVA 201
            |...||::....||:.||.||.|||..||.:|       ...|:|.|.|.|.:....|.:.:.:.
  Rat   211 LRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEIL 275

  Fly   202 EEETQFTYQKKKGIAAERKEAKHEKMEADRYTRLQNEYNEKQ---VEYQLFRLFHVERDIRKFTS 263
            .|.......:.|.:..|:...:.||..|..:..|:||..:|:   .:|.::
  Rat   276 NEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFKKKNHICQYYIY-------------- 326

  Fly   264 DLEVRQQEVKAVEQRKEAADEILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKV 328
            ||:.|..|:|.   :||...|..:|..:.:..::.::...:..:::.|.::||......:.|||.
  Rat   327 DLQNRIAEMKT---QKEKIHEDTKEITEKSNVLSNEMKAKNSAVKDIEKKLNKVTKFIEQNKEKF 388

  Fly   329 THCKKKLISLQKTLETAREADNAHQSDIRKLEKQL----ADVEALKK--RFEDEIENESQRRGKS 387
            |....:.:.:::.|:.|       .|..:||||||    ..||.||.  .....:.||:..|..|
  Rat   389 TQLDLEDVQVREKLKHA-------TSKAKKLEKQLQKDKEKVEELKSIPAKSKNVINETTTRNNS 446

  Fly   388 VNM-----EEGLVQEYDRLKQEAEATATQYRSELDSVNREQKSEQDTLDG------ETNRRASVE 441
            :..     |:.|.:..|.||||.:           .:.:|::.::..|.|      |...:..|.
  Rat   447 LEKEREKEEKKLKEVMDSLKQETQ-----------GLQKEKEIQEKELMGFNKSVNEARSKMEVA 500

  Fly   442 ESFKKLTLQREE-AVKRRDKLMDHIKSSQAALEEQNRIKDELRRDVGTSKEKIAEKQRELE---- 501
            :|...:.|.|.. ||.:..|..|.:.::...|:|:.....::...:..:::::.||::||:
  Rat   501 QSELDIYLSRHNTAVSQLSKAKDALITASETLKERKAAIKDINTKLPQAQQELKEKEKELQKLTQ 565

  Fly   502 ----------DVRDQLGDAKSDKHEDARRKKKQEVVELFKK--QVPGVYDRMINMCQPTHKRYNV 554
                      |:..::.:|||....:..|.|..:.:...||  ::||:|.|:.:: ....::|::
  Rat   566 EEINLKSLVHDLFQKVEEAKSSLATNRSRGKVLDAIIQEKKSGRIPGIYGRLGDL-GAIDEKYDI 629

  Fly   555 AVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPLKERLRNISDPRNVRLV 619
            |::... ..::.|:||:..||:.|:..||:..:.|.||:.||.:.|  ..:::..|..|.|...:
  Rat   630 AISSCC-HALDYIVVDSIDTAQECVNFLKKHNIGVATFIGLDKMAV--WAQKMNKIQTPENTPRL 691

  Fly   620 FDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALALDGTFYQKSGLISGGSHD 684
            ||::|.:.:||.:|..||..:.||....:.|.:|||:.|| |:..:.|.|...::||.::||...
  Rat   692 FDLVKVKNEEIRQAFYFALRDTLVANNLDQATRVAYQRDR-RWRVVTLQGQIIEQSGTMTGGGSK 755

  Fly   685 LAR-----------------KAKRWDEKHMAQ-LKMQKERLQEELKELVKKSRKQSELA-TVE-- 728
            :.|                 |.:...|:|..| .::|::::|.| :.:||..:.:.|:. |:|
  Rat   756 VMRGRMGSSVVDEISVEEVNKMECQLERHSKQAAQVQEQKVQHE-EAIVKLKQSEREMRNTLEKF 819

  Fly   729 -SQIKGLENRLKYSMVDLESSKKSISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIKE 792
             :.|:||..:.:|..|.::..:.::         :.:..|:...|:||                |
  Rat   820 TASIQGLSEQEEYLCVQIKELEANV---------LTTAPDKKQQKLLE----------------E 859

  Fly   793 NMNNVEDKVYASFCRRLG-----VKNIR----QYEERELVMQQERARKRAEFEQQIDSINSQLD- 847
            |: ||..|.|.:...:.|     :|.:.    ....|:|..||.:          :|:||.|||
  Rat   860 NV-NVFKKEYDAVAEKAGKVEAEIKRLHDTIIDINNRKLKAQQNK----------LDTINKQLDE 913

  Fly   848 ------------------FEKQKDTKKNVERWERSVQDEEDALEGLKLAEARYLKEIDEDKEKME 894
                              .:|.:|   :|.|.|:.::|.|..:..||..    ||.|:::.|  |
  Rat   914 CASAITKAQVAIKTADRNLKKAQD---SVCRTEKEIKDTEKEINDLKTE----LKNIEDNAE--E 969

  Fly   895 KFKQDKQAKK-------------QAVDDMEEDISKARKDVANLAKEIHNVGSHLSAVESKIEAKK 946
            ..|..|.|:|             |.:..::::....:||..::..::..:..|:|...|||:..:
  Rat   970 VIKNTKDAEKSLPEIQKEHRALLQELKVIQDNEHALQKDALSIKLKLEQIDGHISEHNSKIKYWQ 1034

  Fly   947 NERQNILLQAKTDCIVVPLLRGSLDDAVRQSDPDVPSTSAAMENIIEVDYSSLPREYTKLKDD-- 1009
            .|...|.|....|..|..:...|.:|......||..:...|:          |..:..::|.:
  Rat  1035 KEISKIKLHPVEDNPVETVSVLSQEDLEAIKSPDSITNQIAL----------LEAQCREMKPNLG 1089

  Fly  1010 --SAFKKTHEMLQKDLQSKLDVLERIQTPNMKALQKLDAVTEKVQSTNEEFENARKKAKRAKAAF 1072
              :.:||..|:          .|:|:        .:||.:|       .|.:|.|:       |:
  Rat  1090 AIAEYKKKEEL----------YLQRV--------GELDKIT-------SERDNFRQ-------AY 1122

  Fly  1073 ERVKNERSSRFVACCQHISDAIDGIYKKLARNEAAQAYIGPD------NPEEPYLDGINYNCVAP 1131
            |.::.:|.:.|:|....|::.:...|:.|.        :|.|      :..:|:.:||.::...|
  Rat  1123 EDLRKQRLNEFMAGFYVITNKLKENYQMLT--------LGGDAELELVDSLDPFSEGIMFSVRPP 1179

  Fly  1132 GKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTNIGKVASYIRDHTTNLQT 1196
            .|.::.:.||||||||:::|||:|:.|.:.|.|.:.:||||||||..|:..||.||.:.|.|.|.
  Rat  1180 KKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQF 1244

  Fly  1197 IVISLKEEFYGHADALVGI 1215
            |:|||:...:..:|.|:||
  Rat  1245 IIISLRNNMFEISDRLIGI 1263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	331/1319 (25%)
		ABC_SMC1_euk	27..>171	CDD:213242	56/156 (36%)
		SMC_hinge	535..653	CDD:214944	34/117 (29%)
		DUF4700	<697..>810	CDD:292399	24/117 (21%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	41/86 (48%)
Smc4	NP_001032262.2	ABC_SMC4_euk	80..>239	CDD:213241	56/157 (36%)
		SMC_N	81..1272	CDD:280601	331/1319 (25%)
		BAR	<335..>414	CDD:299863	17/88 (19%)
		SMC_hinge	611..725	CDD:214944	34/117 (29%)
		ABC_SMC4_euk	<1179..1273	CDD:213241	41/85 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D326079at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820