Protein Alignment SMC1 and Smc3

DIOPT Version :9

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_113771.2
• Gene: Smc3 / 29486
• RGDID: 62006
• Length: 1217
• Species: Rattus norvegicus
• Alignment Length: 1370
• Identity: 296/1370 - (21%)
• Similarity: 558/1370 - (40%)
• Gaps: 362/1370 - (26%)

  Fly    26 FLEYIEMENFKSYRGHIVVGPL-KQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIH 89
            :::.:.::.|:|||...:|.|. .:.|.::|.||||||||..||.||:.::.|.||.::...|:|
  Rat     2 YIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLH 66

  Fly    90 GSSIGKPVSRSCYVTAKFVLNEER------HMDFQRAVIGGSSEYRINGESVSSSTYLNKLEKIG 148
            ..:  .|...|.:|...|..::.|      .:..:|.:.....:|.::.:.|:.:..:|.||..|
  Rat    67 EGT--GPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAG 129

  Fly   149 INVKAKNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQKKK 213
            .:.....::|.||.:..:|.....:|..|..|::|:.:    |:..|:|.|...:||
  Rat   130 FSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRV----YDERKEESISLMKET-------- 182

  Fly   214 GIAAERKEAKHEKME------ADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQEV 272
                   |.|.||:.      .:|...|:.| .|:..:||.:.......:...:..:|...:.::
  Rat   183 -------EGKREKINELLKYIEERLHTLEEE-KEELAQYQKWDKMRRALEYTIYNQELNETRAKL 239

  Fly   273 KAVEQRKEAADEILREKKKDAGKITRD-LAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLI 336
            ..:..::|.:.|..|: .:||.:..|| :..|::::||.:|:::..:    :.||:::..:::.|
  Rat   240 DELSAKRETSGEKSRQ-LRDAQQDARDKMEDIERQVRELKTKISAMK----EEKEQLSAERQEQI 299

  Fly   337 SLQKTLETAREADNAHQSDIRKLEKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLVQ----- 396
                                    ||...:|...|..:||:...|::|.:.:...:.|::
  Rat   300 ------------------------KQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEK 340

  Fly   397 ---------EYDRLKQEAE------ATATQYRSELDS-----------------VNREQKSEQDT 429
                     :::.:|::.|      |.|||.|::|.:                 :.:|.||....
  Rat   341 QKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQA 405

  Fly   430 LDGETNRRASVEESFKKLTLQREEAVKRRDKLMDHIKSSQAALEEQNR-------IKDELR---- 483
            ::.:..:.|::.:..:.....:|:.:::.:||...:...:|.:||.:|       .||||:
  Rat   406 INDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERN 470

  Fly   484 ---RDVGTSKEKIAEKQRELEDVRDQLGDAKSDKH------------EDARRKKKQEVVELFKKQ 533
               |:....::.:|.|:.:||. :.||..|.:.|.            :..|||...:.|:
  Rat   471 YLWREENAEQQALAAKREDLEK-KQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQ----- 529

  Fly   534 VPGVYDRMIN--MCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVE-TFLPL 595
             .|.:..::|  .|:|.   :...|....|..:...|||:::.:...:....:..|..| |||||
  Rat   530 -NGYHGIVMNNFECEPA---FYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPL 590

  Fly   596 DYLQVKPLKERLRNISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRS 660
            :.|.|:.......|.:.|     :...|::.|: .::|.....|..|:|.    :|:|:.::.|:
  Rat   591 NKLDVRDTAYPETNDAIP-----MISKLRYNPR-FDKAFKHVFGKTLICR----SMEVSTQLARA 645

  Fly   661 -RFDALALDGTFYQKSGLISGGSHDLARKAKRWDEKHMAQLKMQKE--RLQEELKELVKKSRKQS 722
             ..|.:.|:|......|.::||.:| .||::         |::||:  :.:|||.||..|
  Rat   646 FTMDCITLEGDQVSHRGALTGGYYD-TRKSR---------LELQKDVRKAEEELGELEAK----- 695

  Fly   723 ELATVESQIKGLENRLKYSMVDLESSKKSISQYDNQLQQVQSQLDEFGP---------KILEIER 778
                       |...|:.   ::|.....|.|..||:||:::|..:|..         |:|: |:
  Rat   696 -----------LNENLRR---NIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLK-EK 745

  Fly   779 RMQNREEHIQEIKENMNNVEDKVYASFCRRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSIN 843
            |.|: |:.....:.::.::|..::|                    |:..|...:||..   ..:.
  Rat   746 RQQS-EKTFMPKQRSLQSLEASLHA--------------------MESTRESLKAELG---TDLL 786

  Fly   844 SQLDFEKQK------DTKKNVERWERSVQDEEDALEGLKLAEARYL-----KEIDEDKEKMEKFK 897
            |||..|.||      |..:.:::..|.:.:|...|||:......||     |.:|:.::::.:.:
  Rat   787 SQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELR 851

  Fly   898 Q----------------------DKQAKKQ----AVDDMEEDISKARKDV---ANLAKEIHNVGS 933
            :                      |..|:.:    ::|..|..|.:.:|.:   .|:.||
  Rat   852 ETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKE------ 910

  Fly   934 HLSAV--ESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVRQSDPDVPSTSAAMENIIEVDY 996
            |:.|:  ::|...|...||.:||:.|.:|                           |:.|.|:
  Rat   911 HMDAINHDTKELEKMTNRQGMLLKKKEEC---------------------------MKKIREL-- 946

  Fly   997 SSLPREYTKLKDDSAFKKTHEMLQKDLQSKLD----VLERIQTPNMKALQK---LDAVTEKVQST 1054
            .|||:|        ||:|...:..|.|..||:    .|::....|.|||.:   .....||:...
  Rat   947 GSLPQE--------AFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKR 1003

  Fly  1055 NEEFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARN--EAAQAYI------ 1111
            .||.:...|.........|..|.|              ||...:|::::|  |..|..:
  Rat  1004 QEELDRGYKSIMELMNVLELRKYE--------------AIQLTFKQVSKNFSEVFQKLVPGGKAT 1054

  Fly  1112 ---------GPDNPEE-----------------PYLD---GINYNCVAPGKR--FQPMNNLSGGE 1145
                     |..:.:|                 |.:|   |:.......||:  .:.|..||||:
  Rat  1055 LVMKKGDVEGSQSQDEGEGSGESERGSGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQ 1119

  Fly  1146 KTIAALALLFSTHSFHPAPFFVLDEIDAALDNTNIGKVASYIRDHTTNLQTIVISLKEEFYGHAD 1210
            |::.||||:|:.....||||::.||||.|||..:...|:..|.:...:.|.|..:.:.|....||
  Rat  1120 KSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIMELAVHAQFITTTFRPELLESAD 1184

  Fly  1211 ALVGI 1215
            ...|:
  Rat  1185 KFYGV 1189

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	Smc	26..1216	CDD:224117	296/1370 (22%)
		ABC_SMC1_euk	27..>171	CDD:213242	41/150 (27%)
		SMC_hinge	535..653	CDD:214944	27/120 (23%)
		DUF4700	<697..>810	CDD:292399	28/123 (23%)
		ABC_SMC1_euk	<1130..1232	CDD:213242	32/88 (36%)
Smc3	NP_113771.2	Smc	1..1194	CDD:224117	296/1370 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..269		7/27 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1059..1090		3/30 (10%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810