Protein Alignment SMC1 and SMC1B

DIOPT Version :10

• Sequence 1: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_683515.4
• Gene: SMC1B / 27127
• HGNCID: 11112
• Length: 1235
• Species: Homo sapiens
• Alignment Length: 1229
• Identity: 509/1229 - (41%)
• Similarity: 779/1229 - (63%)
• Gaps: 23/1229 - (1%)

  Fly    25 AFLEYIEMENFKSYRGHIVVGPLKQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIH 89
            |.||.:.:|||||:||..|:||.::|..:||||||||||.|||:|||||||.::||||.:.:|||
Human     2 AHLELLLVENFKSWRGRQVIGPFRRFTCIIGPNGSGKSNVMDALSFVMGEKIANLRVKNIQELIH 66

  Fly    90 GSSIGKPVSRSCYVTAKFVLNEERHMDFQRAVIGGSSEYRINGESVSSSTYLNKLEKIGINVKAK 154
            |:.||||:|.|..|...:|........|.|.:.||.||:|.|...||.|.|:.:||||||.|||:
Human    67 GAHIGKPISSSASVKIIYVEESGEEKTFARIIRGGCSEFRFNDNLVSRSVYIAELEKIGIIVKAQ 131

  Fly   155 NFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQKKKGIAAER 219
            |.|||||.||:|::|.|||||..|||||.||.|..:|...|:::..|||:.||.:.|||.|||||
Human   132 NCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAER 196

  Fly   220 KEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQEVKAVEQRKEAADE 284
            ::||.||.||:||..|..|....:::.|||:|:|.|:.|....:.||...:::....:.....:.
Human   197 RQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHEN 261

  Fly   285 ILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKTLETAREAD 349
            |::.:||:.|.:||.|.:.::|::..||.:|::||.||||||..:|..|||...:|:::.:.:..
Human   262 IVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQC 326

  Fly   350 NAHQSDIRKLEKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLVQEYDRLKQEAE---ATATQ 411
            :..:.||:.||.:|||::|..:.||.:||.|...:.:.:.:|...:..|..||::..   ||.||
Human   327 SKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQ 391

  Fly   412 YRSELDSVNREQKSEQDTLDGETNRRASVEESFKKLTLQREEAVKRRDKLMDHIKSSQAALEEQN 476
               :|:.:..|||::::.|..|..|...|:.:.|::..|.|:..||.:||.::.|:....|:|:.
Human   392 ---QLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKK 453

  Fly   477 RIKDELRRDVGTSKEKIAEKQRELEDVRDQLGDAKSDKHEDARRKKKQEVVELFKKQVP-GVYDR 540
            :.::.|..::..:|.:::|...||..:|.:|.:|..|.||..|::|:.||:|..|:..| .|:.|
Human   454 QQEETLVDEIEKTKSRMSEVNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGR 518

  Fly   541 MINMCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPLKE 605
            :.::|.|.||:|.:|||||.|:|:.||:|.:||.|:.||:.|||:..|.||||.||||.:||:.|
Human   519 LFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINE 583

  Fly   606 RLRNISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALALDGT 670
            |||.:   :..::|.||:|.:..::::.:.|..||.|||||.|:|..:|.. ...|...:|||||
Human   584 RLREL---KGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALS-GPERQKTVALDGT 644

  Fly   671 FYQKSGLISGGSHDLARKAKRWDEKHMAQLKMQKERLQEELKELVKKSRKQSELATVESQIKGLE 735
            .:.|||:|||||.||..||:.||||.:..|:.::.:..:|||.|:|..||:::|..:::.|:|.:
Human   645 LFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQ 709

  Fly   736 NRLKYSMVDLESSKKS--ISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIKENMNNVE 798
            .|||||..:||..||.  ::.|..| .|:||:|.....:.:.:...::.|:..|:|.:|.::.||
Human   710 TRLKYSQNELEMIKKKHLVAFYQEQ-SQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVE 773

  Fly   799 DKVYASFCRRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSINSQLDFEKQKDTKK--NVERW 861
            |.::..||..:||:|||::|.:.:..|||..:||.|||:|...:|.||::.:....||  .:...
Human   774 DDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTL 838

  Fly   862 ERSVQDEEDALEGLKLAEARYLKEIDEDKEKMEKFKQDKQAKKQAVDDMEEDISKARKDVANLAK 926
            :.::|...:.::.||.||...|:.::|...|.::.|..:..:..:.:.::..|.:.||....:.:
Human   839 KETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDR 903

  Fly   927 EIHNVGSHLSAVESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVR-QSDPDVPSTSAAM-- 988
            |:..:...:.::::.:|.|:.|:.|:||..|...|.:.||.|||||.:. :...:..||.|.:
Human   904 EVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDI 968

  Fly   989 ---ENIIEVDYSSLPREYTKLKDDSAFKKTHEMLQKDLQSKLDVLERIQTPNMKALQKLDAVTEK 1050
               |...|:|||||..:...|:.|...:....:|.:.:.|:.|:|.:...||::||:.|..|.:|
Human   969 YEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTVRDK 1033

  Fly  1051 VQSTNEEFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEAAQAYIGPDN 1115
            .|.:.:.||.:||:|:..:..||:||..|...|..|.:|:|.:||.|||||.||.:|||::.|:|
Human  1034 FQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFEHVSISIDQIYKKLCRNNSAQAFLSPEN 1098

  Fly  1116 PEEPYLDGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTNI 1180
            ||||||:||:||||||||||.||:|||||||.:|||||||:.|||.|||||||||:|||||||||
Human  1099 PEEPYLEGISYNCVAPGKRFMPMDNLSGGEKCVAALALLFAVHSFRPAPFFVLDEVDAALDNTNI 1163

  Fly  1181 GKVASYIRDHTTN-LQTIVISLKEEFYGHADALVGITPGEGDCLVSNVYIMDLTTFEDT 1238
            |||:|||::.|.: .|.||||||||||..||||:||.|...||:.|.|..:||:.:.||
Human  1164 GKVSSYIKEQTQDQFQMIVISLKEEFYSRADALIGIYPEYDDCMFSRVLTLDLSQYPDT 1222

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1	NP_651211.2	SMC_N	26..1222	CDD:481474	500/1210 (41%)
SMC1B	NP_683515.4	SMC_N	3..1206	CDD:481474	500/1210 (41%)